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Molecular Motor Transport through Hollow Nanowires
Lund Univ.
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences.ORCID iD: 0000-0001-6878-3142
Lund Univ / Univ Copenhagen.
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences.ORCID iD: 0000-0002-5889-7792
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2014 (English)In: Nano letters (Print), ISSN 1530-6984, E-ISSN 1530-6992, Vol. 14, no 6, 3041-3046 p.Article in journal (Refereed) Published
Abstract [en]

Biomolecular motors offer self-propelled, directed transport in designed microscale networks and can potentially replace pump-driven nanofluidics. However, in existing systems, transportation is limited to the two-dimensional plane. Here we demonstrate fully one-dimensional (1D) myosin-driven motion of fluorescent probes (actin filaments) through 80 nm wide, Al2O3 hollow nanowires of micrometer length. The motor-driven transport is orders of magnitude faster than would be possible by passive diffusion. The system represents a necessary element for advanced devices based on gliding assays, for example, in lab-on-a-chip systems with channel crossings and in pumpless nanosyringes. It may also serve as a scaffold for bottom-up assembly of muscle proteins into actin ordered contractile units, mimicking the muscle sarcomere.

Place, publisher, year, edition, pages
2014. Vol. 14, no 6, 3041-3046 p.
Keyword [en]
Hollow nanowires, actin, myosin, molecular motors, motor proteins, 1D gliding assay
National Category
Materials Chemistry
Research subject
Natural Science, Biomedical Sciences
Identifiers
URN: urn:nbn:se:lnu:diva-36091DOI: 10.1021/nl404714bISI: 000337337100012OAI: oai:DiVA.org:lnu-36091DiVA: diva2:734428
Available from: 2014-07-17 Created: 2014-07-17 Last updated: 2016-05-03Bibliographically approved

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ten Siethoff, LasseMånsson, Alf
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