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Influence of persistent organic pollutants on the complement system in a population-based human sample
Uppsala University.
Uppsala University.
Uppsala University.
Örebro University.
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2014 (English)In: Environment International, ISSN 0160-4120, E-ISSN 1873-6750, Vol. 71, 94-100 p.Article in journal (Refereed) Published
Abstract [en]

Background: Persistent organic pollutants (POPS) are toxic compounds generated through various industrial activities and have adverse effects on human health. Studies performed in cell cultures and animals have revealed that POPs can alter immune-system functioning. The complement system is part of innate immune system that helps to clear pathogens from the body. We performed a large-scale population-based study to find out associations between summary measures of different POPs and different complement system markers. Methods: In this cross-sectional study, 16 polychlorinated biphenyls (PCBs), 3 organochlorine (OC) pesticides, octachloro-p-dibenzodioxin, and 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) were analyzed for their association with levels of protein complement 3 (C3), 3a (C3a), 4 (C4) and C3a/C3 ratio. A total of 992 individuals (all aged 70 years, 50% females) were recruited from the Prospective Investigation of the Vasculature in Uppsala Seniors cohort. Regression analysis adjusting for a variety of confounders was performed to study the associations of different POP exposures (total toxic equivalency value or TEQ and sum of 16 PCBs) with protein complements. Results: The TEQ values were found to be positively associated with C3a (beta = 0.07, 95% CI = 0.017-0.131, p = 0.01) and C3a/C3 ratio (beta = 0.07, 95% Cl = 0.015-0.126, p = 0.01) taking possible confounders into account. The association observed was mainly driven by PCB-126. Conclusion: In this study involving 992 elderly individuals from the general population, we showed that POPs, mainly PCB-126, were associated with levels of complement system markers indicating that the association of these toxic compounds with downstream disease could be mediated by activation of immune system. (C) 2014 Elsevier Ltd. All rights reserved.

Place, publisher, year, edition, pages
2014. Vol. 71, 94-100 p.
Keyword [en]
Complement system markers, Epidemiology, Persistent organic pollutants, TEQ
National Category
Environmental Health and Occupational Health
Research subject
Biomedical Sciences, Immunology
Identifiers
URN: urn:nbn:se:lnu:diva-37355DOI: 10.1016/j.envint.2014.06.009ISI: 000209036100011OAI: oai:DiVA.org:lnu-37355DiVA: diva2:750616
Available from: 2014-09-29 Created: 2014-09-29 Last updated: 2017-02-16Bibliographically approved

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Nilsson Ekdahl, Kristina
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Department of Chemistry and Biomedical Sciences
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CiteExportLink to record
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Cite
Citation style
  • apa
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More styles
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