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Cell surface engineering for regulation of immune reactions in cell therapy
University of Tokyo, Japan.
Uppsala University.
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences. Uppsala University. (BMC)ORCID iD: 0000-0001-7888-1571
Uppsala University.
2015 (English)In: Immune Responses to Biosurfaces: Mechanisms and Therapeutic Interventions / [ed] John D. Lambris, Kristina Nilsson-Ekdahl, Daniel Ricklin, Bo Nilsson, Springer, 2015, p. 189-209Chapter in book (Refereed)
Abstract [en]

Transplantation of the pancreatic islets of Langerhans (islets) is a promising cell therapy for treating insulin-dependent type 1 diabetes mellitus. Islet transplantation is a minimally-invasive technique involving relatively simple surgery. However, after intraportal transplantation, the transplanted islets are attacked by the recipient’s immune system, because they activate a number of systems, including coagulation, complement response, inflammation, immune rejection, and recurrence of autoimmune disease. We have developed a surface modification and microencapsulation technique that protects cells and islets with biomaterials and bioactive substances, which may be useful in clinical settings. This approach employs amphiphilic polymers, which can interact with lipid bilayer membranes, without increasing cell volume. Molecules attached to these polymers can protect transplanted cells and islets from attack by the host immune system. We expect that this surface modification technique will improve graft survival in clinical islet transplantation.

Place, publisher, year, edition, pages
Springer, 2015. p. 189-209
Series
Advances in Experimental Medicine and Biology, ISSN 0065-2598 ; 865
National Category
Immunology
Research subject
Biomedical Sciences, Immunology
Identifiers
URN: urn:nbn:se:lnu:diva-40420DOI: 10.1007/978-3-319-18603-0_12ISBN: 978-3-319-18602-3 (print)ISBN: 978-3-319-18603-0 (print)OAI: oai:DiVA.org:lnu-40420DiVA, id: diva2:790671
Available from: 2015-02-25 Created: 2015-02-25 Last updated: 2018-06-12Bibliographically approved

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Nilsson Ekdahl, Kristina

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CiteExportLink to record
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