There is a need of more advanced analysis for studying how the long-term behaviour of glued laminated timber structures is affected by creep and by cyclic variations in climate. A beam theory is presented able to simulate the overall hygro-mechanical and visco-elastic behaviour of (inhomogeneous) glulam structures. Two frame structures subjected to both mechanical and cyclic environmental loading are analysed to illustrate the advantages the model involved can provide. The results indicate clearly both the (discontinuous) inhomogeneity of the glulam products and the variable moisture-load action that occurs to have a significant effect on deformations, section forces and stress distributions within the frame structures that were studied.