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Hierarchical Thin Film Architectures for Enhanced Sensor Performance: Liquid Crystal-Mediated Electrochemical Synthesis of Nanostructured Imprinted Polymer Films for the Selective Recognition of Bupivacaine
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences. (BBCL ; BMC)
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences. (BBCL)
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences. (BBCL)
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences. Uppsala University. (BMC ; BBCL)ORCID iD: 0000-0002-0407-6542
2014 (English)In: Biosensors, ISSN 2079-6374, Vol. 4, no 2, 90-110 p.Article in journal (Refereed) Published
Abstract [en]

Nanostructured bupivacaine-selective molecularly imprinted 3-aminophenylboronic acid-p-phenylenediamine co-polymer (MIP) films have been prepared on gold-coated quartz (Au/quartz) resonators by electrochemical synthesis under cyclic voltammetric conditions in a liquid crystalline (LC) medium (triton X-100/water). Films prepared in water and in the absence of template were used for control studies. Infrared spectroscopic studies demonstrated comparable chemical compositions for LC and control polymer films. SEM studies revealed that the topologies of the molecularly imprinted polymer films prepared in the LC medium (LC-MIP) exhibit discernible 40 nm thick nano-fiber structures, quite unlike the polymers prepared in the absence of the LC-phase. The sensitivity of the LC-MIP in a quartz crystal microbalance (QCM) sensor platform was 67.6 ± 4.9 Hz/mM under flow injection analysis (FIA) conditions, which was ≈250% higher than for the sensor prepared using the aqueous medium. Detection was possible at 100 nM (30 ng/mL), and discrimination of bupivacaine from closely related structural analogs was readily achieved as reflected in the corresponding stability constants of the MIP-analyte complexes. The facile fabrication and significant enhancement in sensor sensitivity together highlight the potential of this LC-based imprinting strategy for fabrication of polymeric materials with hierarchical architectures, in particular for use in surface-dependent application areas, e.g., biomaterials or sensing.

Place, publisher, year, edition, pages
2014. Vol. 4, no 2, 90-110 p.
Keyword [en]
bupivacaine, electropolymerization, liquid crystal, molecularly imprinted polymer, nanostructured polymer films, piezoelectric sensor, quartz crystal microbalance
National Category
Materials Chemistry
Research subject
Chemistry, Organic Chemistry
Identifiers
URN: urn:nbn:se:lnu:diva-42605DOI: 10.3390/bios4020090OAI: oai:DiVA.org:lnu-42605DiVA: diva2:805622
Funder
Swedish Research CouncilKnowledge Foundation
Available from: 2015-04-15 Created: 2015-04-15 Last updated: 2017-02-16Bibliographically approved

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Suriyanarayanan, SubramanianNdizeye, NatachaNicholls, Ian A.
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