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Membrane Protein Structure, Function, and Dynamics: a Perspective from Experiments and Theory
Academy of Athens, Greece.
University of California, USA ; RMIT University, Australia.
University of California, USA.
Université de Nice Sophia-Antipolis, France. (Centre National de la Recherche Scientifique)
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2015 (English)In: Journal of Membrane Biology, ISSN 0022-2631, E-ISSN 1432-1424, Vol. 248, no 4, p. 611-640Article in journal (Refereed) Published
Abstract [en]

Membrane proteins mediate processes that are fundamental for the flourishing of biological cells. Membrane-embedded transporters move ions and larger solutes across membranes; receptors mediate communication between the cell and its environment and membrane-embedded enzymes catalyze chemical reactions. Understanding these mechanisms of action requires knowledge of how the proteins couple to their fluid, hydrated lipid membrane environment. We present here current studies in computational and experimental membrane protein biophysics, and show how they address outstanding challenges in understanding the complex environmental effects on the structure, function, and dynamics of membrane proteins.

Place, publisher, year, edition, pages
Springer, 2015. Vol. 248, no 4, p. 611-640
Keywords [en]
Membrane proteins, Lipids, Protein structure, Protein function, Protein dynamics, Membrane-mediated interactions
National Category
Biophysics Theoretical Chemistry
Research subject
Natural Science
Identifiers
URN: urn:nbn:se:lnu:diva-45622DOI: 10.1007/s00232-015-9802-0ISI: 000358417900001Scopus ID: 2-s2.0-84938984910OAI: oai:DiVA.org:lnu-45622DiVA, id: diva2:844344
Available from: 2015-08-05 Created: 2015-08-05 Last updated: 2017-12-04Bibliographically approved

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Friedman, Ran

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