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Complement and platelets: Mutual interference in the immune network
Med Univ Innsbruck, Austria.
Med Univ Innsbruck, Austria.
Med Univ Innsbruck, Austria.
Med Univ Innsbruck, Austria.
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2015 (English)In: Molecular Immunology, ISSN 0161-5890, E-ISSN 1872-9142, Vol. 67, no 1, 108-118 p.Article, review/survey (Refereed) Published
Abstract [en]

In recent years, the view of platelets has changed from mere elements of hemostasis to immunological multitaskers. They are connected in manifold ways to other cellular and humoral components of the immune network, one of which is the complement system, a potent player in soluble innate immunity. Our article reviews the crucial and complex interplay between platelets and complement, focusing on mutual regulation of these two interaction partners by their respective molecular mechanisms. Furthermore, the putative relevance of these processes to infectious diseases, inflammatory conditions, and autoimmune disorders, as well as the treatment of patients with biomaterials is highlighted. (C) 2015 Elsevier Ltd. All rights reserved.

Place, publisher, year, edition, pages
2015. Vol. 67, no 1, 108-118 p.
Keyword [en]
Complement, Platelets, Innate immunity, Immune network, Infectious diseases, Autoimmunity and inflammatory disorders, Biomaterials
National Category
Immunology
Research subject
Biomedical Sciences, Immunology
Identifiers
URN: urn:nbn:se:lnu:diva-45771DOI: 10.1016/j.molimm.2015.03.244ISI: 000357144100012PubMedID: 25886718OAI: oai:DiVA.org:lnu-45771DiVA: diva2:847352
Available from: 2015-08-20 Created: 2015-08-19 Last updated: 2017-02-16Bibliographically approved

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Nilsson Ekdahl, Kristina
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Department of Chemistry and Biomedical Sciences
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CiteExportLink to record
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