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Coronary blood flow in the anesthetized American alligator (Alligator mississippiensis)
Univ Amsterdam, Netherlands.
Linnaeus University, Faculty of Health and Life Sciences, Department of Biology and Environmental Science.
Rockefeller Wildlife Refuge, USA.
Aarhus Univ, Denmark.
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2016 (English)In: Comparative Biochemistry and Physiology A, ISSN 1095-6433, E-ISSN 1531-4332, Vol. 191, 44-52 p.Article in journal (Refereed) Published
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Abstract [en]

Coronary circulation of the heart evolved early within ectothermic vertebrates and became of vital importance to cardiac performance in some teleost fish, mammals and birds. In contrast, the role and function of the coronary circulation in ectothermic reptiles remains largely unknown. Here, we investigated the systemic and coronary arterial responses of five anesthetized juvenile American alligators (Alligator mississippiensis) to hypoxia, acetylcholine, adenosine, sodium nitroprusside, isoproterenol, and phenylephrine. We recorded electrocardiograms, monitored systemic blood pressure, blood flows in both aortae, and blood flow in a major coronary artery supplying most of the right ventricle. Coronary arterial blood flow was generally forward, but there was a brief retrograde flow during a ventricular contraction. Blood pressure was significantly changed in all conditions. Acetylcholine decreased coronary forward flow, but this response was confounded by the concomitant lowered work of the ventricles due to decreased heart rate and blood pressure. Coronary forward flow was poorly correlated with heart rate and mean arterial pressure across treatments. Overall changes in coronary forward flow, significant and not significant, were generally in the same direction as mean arterial pressure and ventricular power, approximated as the product of systemic cardiac output and mean arterial pressure. (c) 2015 Elsevier Inc. All rights reserved.

Place, publisher, year, edition, pages
2016. Vol. 191, 44-52 p.
Keyword [en]
Alligator, Heart, Cardiovascular
National Category
Biological Sciences
Research subject
Natural Science
Identifiers
URN: urn:nbn:se:lnu:diva-49382DOI: 10.1016/j.cbpa.2015.09.018ISI: 000367633100006PubMedID: 26436857OAI: oai:DiVA.org:lnu-49382DiVA: diva2:898543
Available from: 2016-01-28 Created: 2016-01-28 Last updated: 2016-01-28Bibliographically approved

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CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf