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Intra- and Extracellular Activities of Trimethoprim-Sulfamethoxazole against Susceptible and Multidrug-Resistant Mycobacterium tuberculosis
Karolinska Inst ; Karolinska Univ Hosp Solna.
Linnaeus University, Faculty of Health and Life Sciences, Department of Medicine and Optometry. Linköping University.
Uppsala University.
Karolinska Inst ; Karolinska Univ Hosp Solna.
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2014 (English)In: Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, E-ISSN 1098-6596, Vol. 58, no 12, 7557-7559 p.Article in journal (Refereed) Published
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Abstract [en]

We investigated the activity of trimethoprim-sulfamethoxazole (SXT) against Mycobacterium tuberculosis, the pathogen that causes tuberculosis (TB). The MIC distribution of SXT was 0.125/2.4 to 2/38 mg/liter for the 100 isolates tested, including multi- and extensively drug-resistant isolates (MDR/XDR-TB), whereas the intracellular MIC90 of sulfamethoxazole (SMX) for the pansusceptible strain H37Rv was 76 mg/liter. In an exploratory analysis using a ratio of the unbound area under the concentration-time curve from 0 to 24 h over MIC (fAUC(0-24)/MIC) using >= 25 as a potential target, the cumulative fraction response was >= 90% at doses of >= 2,400 mg of SMX. SXT is a potential treatment option for MDR/XDR-TB.

Place, publisher, year, edition, pages
2014. Vol. 58, no 12, 7557-7559 p.
National Category
Microbiology in the medical area
Research subject
Natural Science, Biomedical Sciences
Identifiers
URN: urn:nbn:se:lnu:diva-50683DOI: 10.1128/AAC.02995-14ISI: 000345221000065OAI: oai:DiVA.org:lnu-50683DiVA: diva2:911698
Available from: 2016-03-14 Created: 2016-03-14 Last updated: 2016-05-12Bibliographically approved

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