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A hybrid of cells and pancreatic islets toward a new bioartificial pancreas.
The University of Tokyo, Japan ; Uppsala University.
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences. Uppsala University. (BMC)ORCID iD: 0000-0001-7888-1571
Uppsala University.
2016 (English)In: Regenerative Therapy, ISSN 2352-3204, Vol. 3, no Special Issue, 68-74 p.Article in journal (Refereed) Published
Abstract [en]

Cell surface engineering using single-stranded DNA–poly(ethylene glycol)-conjugated phospholipid (ssDNA–PEG-lipid) is useful for inducing cell–cell attachment two and three dimensionally. In this review, we summarize our recent techniques for cell surface engineering and their applications to islet transplantation. Because any DNA sequence can be immobilized onto the cell surface by hydrophobic interactions between ssDNA–PEG-lipid and the cellular membrane without impairing cell function, a cell–cell hybrid can be formed through the DNA hybridization. With this technique, it would be possible to create three-dimensional hybrid structures of pancreatic islets coated with various accessory cells, such as patients’ own cells, mesenchymal and adipose-derived stem cells, endothelial progenitor cells, neural crest stem cells or regulatory T cells, which might significantly improve the outcome of islet transplantation in diabetic patients.

Place, publisher, year, edition, pages
2016. Vol. 3, no Special Issue, 68-74 p.
National Category
Immunology in the medical area
Research subject
Biomedical Sciences, Immunology
Identifiers
URN: urn:nbn:se:lnu:diva-51505DOI: 10.1016/j.reth.2016.03.004OAI: oai:DiVA.org:lnu-51505DiVA: diva2:915106
Available from: 2016-03-29 Created: 2016-03-29 Last updated: 2017-02-16Bibliographically approved

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Nilsson Ekdahl, Kristina
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CiteExportLink to record
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