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Complement receptor 2 is increased in cerebrospinal fluid of multiple sclerosis patients and regulates C3 function
Karolinska Institutet ; Uppsala University.
Karolinska Institutet.
Karolinska Institutet.
Karolinska Institutet.
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2016 (English)In: Clinical Immunology, ISSN 1521-6616, E-ISSN 1521-7035, Vol. 166, 89-95 p.Article in journal (Refereed) Published
Abstract [en]

Besides its vital role in immunity, the complement system also contributes to the shaping of the synaptic circuitry of the brain. We recently described that soluble Complement Receptor 2 (sCR2) is part of the nerve injury response in rodents. We here study CR2 in context of multiple sclerosis (MS) and explore the molecular effects of CR2 on C3 activation.

Significant increases in sCR2 levels were evident in cerebrospinal fluid (CSF) from both patients with relapsing-remitting MS (n = 33; 6.2 ng/mL) and secondary-progressive MS (n = 9; 7.0 ng/mL) as compared to controls (n = 18; 4.1 ng/mL). Furthermore, CSF sCR2 levels correlated significantly both with CSF C3 and C1q as well as to a disease severity measure. In vitro, sCR2 inhibited the cleavage and down regulation of C3b to iC3b, suggesting that it exerts a modulatory role in complement activation downstream of C3.

These results propose a novel function for CR2/sCR2 in human neuroinflammatory conditions.

Place, publisher, year, edition, pages
2016. Vol. 166, 89-95 p.
National Category
Immunology in the medical area
Research subject
Biomedical Sciences, Immunology
Identifiers
URN: urn:nbn:se:lnu:diva-52309DOI: 10.1016/j.clim.2016.04.003ISI: 000378011500010PubMedID: 27085202Scopus ID: 2-s2.0-84963963835OAI: oai:DiVA.org:lnu-52309DiVA: diva2:924696
Available from: 2016-04-28 Created: 2016-04-28 Last updated: 2017-02-16Bibliographically approved

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Sandholm, KerstinNilsson Ekdahl, Kristina
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CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
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  • Other locale
More languages
Output format
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