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Complement inhibition in biomaterial- and biosurface-induced thromboinflammation
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences. Uppsala University. (BMC)ORCID iD: 0000-0001-7888-1571
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences.
Uppsala University.
Uppsala University ; The University of Tokyo, Japan.
2016 (English)In: Seminars in Immunology, ISSN 1044-5323, E-ISSN 1096-3618, Vol. 28, no 3, p. 268-277Article in journal (Refereed) Published
Abstract [en]

Therapeutic medicine today includes a vast number of procedures involving the use of biomaterials, transplantation of therapeutic cells or cell clusters, as well as of solid organs. These treatment modalities are obviously of great benefit to the patient, but also present a great challenge to the innate immune system, since they involve direct exposure of non-biological materials, cells of non-hematological origin as well as endothelial cells, damaged by ischemia-perfusion in solid organs to proteins and cells in the blood. The result of such an exposure may be an inappropriate activation of the complement and contact/kallikrein systems, which produce mediators capable of triggering the platelets and PMNs and monocytes, which can ultimately result in thrombotic and inflammatory (i.e., a thrombo-inflammatory) response to the treatment modality. In this concept review, we give an overview of the mechanisms of recognition within the innate immunity system, with the aim to identify suitable points for intervention. Finally, we discuss emerging and promising techniques for surface modification of biomaterials and cells with specific inhibitors in order to diminish thromboinflammation and improve clinical outcome.

Place, publisher, year, edition, pages
2016. Vol. 28, no 3, p. 268-277
National Category
Immunology in the medical area Microbiology in the medical area
Research subject
Biomedical Sciences, Immunology; Ecology, Microbiology
Identifiers
URN: urn:nbn:se:lnu:diva-52312DOI: 10.1016/j.smim.2016.04.006ISI: 000381845600007PubMedID: 27211838Scopus ID: 2-s2.0-84971261486OAI: oai:DiVA.org:lnu-52312DiVA, id: diva2:924699
Available from: 2016-04-28 Created: 2016-04-28 Last updated: 2018-01-10Bibliographically approved

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Nilsson Ekdahl, KristinaHuang, Shan

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