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Does Celiac Disease Influence Survival in Sepsis?: A Nationwide Longitudinal Study
Kalmar County Hospital ; Örebro University.
Linnaeus University, Faculty of Health and Life Sciences, Department of Biology and Environmental Science. Kalmar County Hospital.
Karolinska Institutet ; Örebro University Hospital.
2016 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 11, no 4, e0154663Article in journal (Refereed) Published
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Abstract [en]

Background Individuals with celiac disease (CD) are at increased risk of sepsis. The aim of this study was to examine whether CD influences survival in sepsis of bacterial origin. Methods Nationwide longitudinal registry-based study. Through data on small intestinal biopsies from Sweden's 28 pathology departments, we identified 29,096 individuals with CD (villous atrophy, Marsh stage III). Each individual with CD was matched with five population-based controls. Among these, 5,470 had a record of sepsis according to the Swedish Patient Register (1,432 celiac individuals and 4,038 controls). Finally we retrieved data on mortality in sepsis patients through the Swedish Cause of Death Registry. Results CD was associated with a 19% increase in overall mortality after sepsis (95% confidence interval (CI) = 1.09-1.29), with the highest relative risk occurring in children (adjusted hazard ratio (aHR) = 1.62; 95% CI = 0.67-3.91). However, aHR for death from sepsis was lower (aHR = 1.10) and failed to reach statistical significance (95% CI = 0.72-1.69). CD did not influence survival within 28 days after sepsis (aHR = 0.98; 95% CI = 0.80-1.19). Conclusions Although individuals with CD seem to be at an increased risk of overall death after sepsis, that excess risk does not differ from the general excess mortality previously seen in celiac patients in Sweden. CD as such does not seem to influence short-term or sepsis-specific survival in individuals with sepsis and therefore is not an independent risk factor for poor prognosis in sepsis.

Place, publisher, year, edition, pages
2016. Vol. 11, no 4, e0154663
National Category
Microbiology in the medical area
Research subject
Ecology, Zoonotic Ecology
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URN: urn:nbn:se:lnu:diva-53273DOI: 10.1371/journal.pone.0154663ISI: 000375211700121Scopus ID: 2-s2.0-84964859397OAI: oai:DiVA.org:lnu-53273DiVA: diva2:935230
Available from: 2016-06-10 Created: 2016-06-10 Last updated: 2016-09-02Bibliographically approved

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CiteExportLink to record
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Citation style
  • apa
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