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Lack of control of hypertension in primary cardiovascular disease prevention in Europe: Results from the EURIKA study
Univ Bologna, Italy.
Hop Bichat Claude Bernard, France ; Univ Paris Diderot, France.
Univ Ghent, Belgium.
Univ Lille Nord France, France.
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2016 (English)In: International Journal of Cardiology, ISSN 0167-5273, E-ISSN 1874-1754, Vol. 218, p. 83-88Article in journal (Refereed) Published
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Abstract [en]

Background: The prevalence of and factors associated with uncontrolled hypertension and apparent resistant hypertension were assessed in the European Study on Cardiovascular Risk Prevention and Management in Usual Daily Practice (EURIKA; NCT00882336). Methods: EURIKA was a cross-sectional observational study including patients being treated for the primary prevention of cardiovascular disease in 12 European countries. Patients were assessed if they were being treated for hypertension (N = 5220). Blood pressure control was defined according to European guidelines, with sensitivity analysis taking account of patients' age and diabetes status. Associated factors were assessed using multivariate analysis. Results: In the primary analysis, a total of 2691 patients (51.6%) had uncontrolled hypertension. Factors significantly associated with an increased risk of having uncontrolled hypertension included female sex (odds ratio [OR]: 2.29; 95% confidence interval [CI]: 1.93-2.73), body mass index (BMI; OR per kg/m(2): 1.03; 95% CI: 1.01-1.04), and geographic location. A total of 749 patients (14.3%) had apparent resistant hypertension. Factors significantly associated with an increased risk of having apparent resistant hypertension included BMI (OR per kg/m(2): 1.06; 95% CI: 1.04-1.08), diabetes (OR: 1.28; 95% CI: 1.06-1.53), use of statins (OR: 1.36; 95% CI: 1.15-1.62), serum uric acid levels (OR: 1.16; 95% CI: 1.09-1.23), and geographic location. Similar results were seen in sensitivity analyses. Conclusions: Over 50% of patients treated for hypertension continued to have uncontrolled blood pressure and 14.3% had apparent resistant hypertension. Positive associations were seen with other cardiovascular risk factors. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

Place, publisher, year, edition, pages
2016. Vol. 218, p. 83-88
Keywords [en]
Hypertension, Cardiovascular disease, Observational study, Primary prevention, Risk factor
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Nursing
Research subject
Health and Caring Sciences
Identifiers
URN: urn:nbn:se:lnu:diva-54674DOI: 10.1016/j.ijcard.2016.05.044ISI: 000377856300015PubMedID: 27232917Scopus ID: 2-s2.0-84969871927OAI: oai:DiVA.org:lnu-54674DiVA, id: diva2:949727
Available from: 2016-07-22 Created: 2016-07-21 Last updated: 2017-11-28Bibliographically approved

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Perk, Joep

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