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Nano-structuring for molecular motor control
Lund University.
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences.ORCID iD: 0000-0001-6878-3142
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences. Delhi Technological University, India.
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences.ORCID iD: 0000-0003-2819-3046
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2015 (English)In: Nano-Structures for Optics and Photonics: Optical Strategies for Enhancing Sensing, Imaging, Communication and Energy Conversion / [ed] Baldassare Di Bartolo, John Collins, Luciano Silvestri, Springer, 2015, 459-459 p.Conference paper, Published paper (Refereed)
Resource type
Text
Abstract [en]

The interaction of self-propelled biological molecular-motors and cytoskeletal filaments holds relevance for a variety of applications such as biosensing, drug screening, diagnostics and biocomputation. The use of these systems for lab-on-a-chip biotechnology applications shows potential for replacement of microfluidic flow by active, molecular-motor driven transport of filaments. The ability to control, confine and detect motile objects in such a system is possible by development of nanostructured surfaces for on-chip applications and fundamental studies of molecular-motors. Here we describe the localized detection (Lard et al., Sci Rep 3:1092, 2013) and fast transport of actin filaments by myosin molecular-motors (Lard et al., Biosens Biolectron 48(0):145–152, 2013), inserted within nanostructures, as a method for biocomputation and molecular concentration. These results include extensive myosin driven concentration of actin filaments on a miniaturized detector, of relevance for use of molecular-motors in a diagnostics platform. Also, we discuss the local enhancement of the fluorescence signal of filaments, relevant for use in a biocomputation device where tracking of potentially thousands of motile objects is of primary significance.

Place, publisher, year, edition, pages
Springer, 2015. 459-459 p.
Series
NATO Science for Peace and Security Series B: Physics and Biophysics, ISSN 1874-6500
National Category
Nano Technology Biochemistry and Molecular Biology
Research subject
Natural Science, Chemistry
Identifiers
URN: urn:nbn:se:lnu:diva-55335DOI: 10.1007/978-94-017-9133-5_28Scopus ID: 2-s2.0-84921667061OAI: oai:DiVA.org:lnu-55335DiVA: diva2:951964
Conference
NATO Advanced Study Institute on Nano-Structures for Optics and Photonics: Optical Strategies for Enhancing, Sensing, Imaging, Communication, and Energy Conversion. Erice, Sicily, Italy, 4–19 July 2013
Available from: 2016-08-11 Created: 2016-08-10 Last updated: 2017-04-21Bibliographically approved

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