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Brain tumor modeling: glioma growth and interaction with chemotherapy
Tehran University of Medical Science, Iran.
Tehran University of Medical Science, Iran.
Tehran University of Medical Science, Iran.
University of Tehran, Iran.
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2011 (English)In: International Conference on Graphic and Image Processing (ICGIP 2011) / [ed] Yi Xie, Yanjun Zheng, 2011, article id 82851MConference paper, Published paper (Refereed)
Abstract [en]

In last decade increasingly mathematical models of tumor growths have been studied, particularly on solid tumors which growth mainly caused by cellular proliferation. In this paper we propose a modified model to simulate the growth of gliomas in different stages. Glioma growth is modeled by a reaction-advection-diffusion. We begin with a model of untreated gliomas and continue with models of polyclonal glioma following chemotherapy. From relatively simple assumptions involving homogeneous brain tissue bounded by a few gross anatomical landmarks (ventricles and skull) the models have been expanded to include heterogeneous brain tissue with different motilities of glioma cells in grey and white matter. Tumor growth is characterized by a dangerous change in the control mechanisms, which normally maintain a balance between the rate of proliferation and the rate of apoptosis (controlled cell death). Result shows that this model closes to clinical finding and can simulate brain tumor behavior properly.

Place, publisher, year, edition, pages
2011. article id 82851M
Series
Proceedings of SPIE, ISSN 0277-786X ; 8285
Keywords [en]
Brain, Modeling, Tissues, Skull, Diffusion, Mathematical modeling
National Category
Cancer and Oncology Medical Engineering
Research subject
Technology (byts ev till Engineering)
Identifiers
URN: urn:nbn:se:lnu:diva-55835DOI: 10.1117/12.913432OAI: oai:DiVA.org:lnu-55835DiVA, id: diva2:956338
Conference
2011 International Conference on Graphic and Image Processing
Available from: 2016-08-30 Created: 2016-08-30 Last updated: 2016-08-31Bibliographically approved

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Khodadad, Davood

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  • apa
  • harvard1
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  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
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  • Other locale
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