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  • 1.
    Bergh, Cecilia
    et al.
    Lund University Hospital, Sweden.
    Bäckström, Martin
    Lund University Hospital, Sweden.
    Jönsson, Henrik
    Lund University Hospital, Sweden.
    Havinder, Lars
    Lund University Hospital, Sweden.
    Johnsson, Per
    Lund University Hospital, Sweden.
    In the eye of both patient and spouse: memory is poor 1 to 2 years after coronary bypass and angioplasty2002In: Annals of Thoracic Surgery, ISSN 0003-4975, E-ISSN 1552-6259, Vol. 74, no 3, p. 689-693Article in journal (Refereed)
    Abstract [en]

    Background. The study aimed to investigate patient and spouse perception of cognitive functioning 1 to 2 years after coronary artery bypass grafting.

    Methods. Seventy-six married patients who had undergone coronary artery bypass grafting were selected and sex- and age-matched with 75 concurrent married patients who had undergone percutaneous transluminal coronary angioplasty. Couples received a letter of explanation and then completed telephone interviews. Forty-seven questions assessed memory, concentration, general health, social functioning, and emotional state. Response choices were: improved, unchanged, or deteriorated function after coronary artery bypass grafting/percutaneous transluminal coronary angioplasty.

    Results. Patients who had undergone coronary artery bypass grafting did not differ in subjective ratings on any measure from patients who had undergone percutaneous transluminal coronary angioplasty. There were no differences between spouses in the respective groups; spouse ratings also did not differ from patient ratings. Only in memory function did patients and spouses report a postprocedural decline.

    Conclusions. No subjective differences were found in patients who had undergone either coronary artery bypass grafting or percutaneous transluminal coronary angioplasty. Spouse ratings agreed with each other and with patient ratings. Positive correlations were found between the questionnaire factors, suggesting that perceived health and well-being are associated with subjective cognition.

  • 2.
    Byden, Moa
    et al.
    Linköping University, Sweden.
    Segernaes, Anna
    Linköping University, Sweden.
    Thulesius, Hans
    Linnaeus University, Faculty of Health and Life Sciences, Department of Medicine and Optometry. Lund University, Sweden.
    Vanky, Farkas
    Linköping University, Sweden.
    Ahlgren, Eva
    Linköping University, Sweden.
    Skoog, Johan
    Linköping University, Sweden.
    Zachrisson, Helene
    Linköping University, Sweden.
    Cerebrovascular Reserve Capacity as a Predictor of Postoperative Delirium: A Pilot Study2021In: Frontiers in Surgery, E-ISSN 2296-875X, Vol. 8, article id 658849Article in journal (Refereed)
    Abstract [en]

    Introduction: Postoperative delirium is a common complication after cardiac surgery with cardiopulmonary bypass (CPB). Compromised regulation of the cerebral circulation may be a predisposing factor for delirium. However, the potential relationship between cerebrovascular reserve capacity and delirium is unknown. The aim of this study was to investigate if impaired cerebrovascular reserve capacity was associated with postoperative delirium.Methods: Forty-two patients scheduled for cardiac surgery with CPB were recruited consecutively. All patients underwent preoperative transcranial Doppler (TCD) ultrasound with calculation of breath-hold index (BHI). BHI < 0.69 indicated impaired cerebrovascular reserve capacity. In addition, patients were examined with preoperative neuropsychological tests such as MMSE (Mini Mental State Examination) and AQT (A Quick Test of cognitive speed). Postoperative delirium was assessed using Nursing Delirium Screening Scale (Nu-DESC) in which a score of >= 2 was considered as delirium.Results: Six patients (14%) scored high for postoperative delirium and all demonstrated impaired preoperative cerebrovascular reserve capacity. Median (25th-75th percentile) BHI in patients with postoperative delirium was significantly lower compared to the non-delirium group [0.26 (-0.08-0.44) vs. 0.83 (0.57-1.08), p = 0.002]. Preoperative MMSE score was lower in patients who developed postoperative delirium (median, 25th-75th percentile; 26.5, 24-28 vs. 28.5, 27-29, p = 0.024). Similarly, patients with postoperative delirium also displayed a slower performance during the preoperative cognitive speed test AQT color and form (mean +/- SD; 85.8 s +/- 19.3 vs. 69.6 s +/- 15.8, p = 0.043).Conclusion: The present findings suggest that an extended preoperative ultrasound protocol with TCD evaluation of cerebrovascular reserve capacity and neuropsychological tests may be valuable in identifying patients with increased risk of developing delirium after cardiac surgery.

  • 3.
    Dautovic Bergh, Cecilia
    et al.
    Lund University, Sweden.
    Bäckström, Martin
    Lund University, Sweden.
    Axelsson, Katarina
    Lund University, Sweden.
    Jönsson, Henrik
    Lund University Hospital, Sweden.
    Johnsson, Per
    Lund University Hospital, Sweden.
    Protein S100B after cardiac surgery: An indicator of long-term anxiety?2007In: Scandinavian Cardiovascular Journal, ISSN 1401-7431, E-ISSN 1651-2006, Vol. 41, no 2, p. 109-113Article in journal (Refereed)
    Abstract [en]

    Objectives. The aim of the study was to assess long-term state and trait anxiety in cardiac surgical risk patients. Design. Thirty two patients with serum S100B > 0.3 µg/l 48 hours after cardiac surgery with cardiopulmonary bypass were matched according to age, gender, type, date and length of surgery with 35 operated patients without elevated S100B. They completed Spielberger's Anxiety Inventory (STAI). Results. Patients with elevated S100B reported more state anxiety and trait anxiety. S100B was an independent predictor of both state and trait anxiety when controlling for perioperative variables. Conclusions. Patients with elevated S100B reported more anxiety 3–6 years after cardiac surgery. A postoperative blood sample can identify risk patients and facilitate appropriate follow-up.

  • 4.
    Fagerberg, Anna
    et al.
    Linnaeus University, Faculty of Health and Life Sciences, Department of Health and Caring Sciences.
    Roskvist, Carina
    Linnaeus University, Faculty of Health and Life Sciences, Department of Health and Caring Sciences. Linneuniversitetet Institutionen för hälso- och vårdvetenskap.
    Beskriva operationssjuksköterskans upplevelse av den perioperativa dialogen med patienten2014Independent thesis Advanced level (degree of Master (One Year)), 5 credits / 7,5 HE creditsStudent thesis
    Abstract [sv]

    Studier samt litteratur visar att patienten upplever oro, rädsla och ångestinför en operation. Genom att studera hur den perioperativa dialogen upplevs avoperationssjuksköterskan som innefattar preoperativ-, intraoperativ- och postoperativdialog så tror vi att tiden på operationsavdelningen kan förbättra den perioperativaprocessen.

  • 5.
    Good, Elin
    et al.
    Linköping University.
    Länne, Toste
    Linköping University.
    Wilhelm, Elisabeth
    Linköping University.
    Perk, Joep
    Linnaeus University, Faculty of Health and Life Sciences, Department of Health and Caring Sciences.
    Jaarsma, Tiny
    Linköping University.
    De Muinck, Ebo
    Linköping University.
    High-grade carotid artery stenosis: A forgotten area in cardiovascular risk management2016In: European Journal of Preventive Cardiology, ISSN 2047-4873, E-ISSN 2047-4881, Vol. 23, no 13, p. 1453-1460Article in journal (Refereed)
    Abstract [en]

    Background Patients with high-grade (≥70%) carotid artery stenosis (CAS) rank in the highest risk category for future cardiovascular (CV) events, but the quality of cardiovascular risk management in this patient group is unknown. Design Cross-sectional retrospective study. Methods Data were collected for all patients diagnosed with high-grade CAS in Östergötland county, Sweden between 1 January 2009 and 31 July 2012 regarding the quality of cardiovascular risk management, co-morbidity and outcomes during the 2-year follow-up period after a diagnosis of CAS with a carotid ultrasound scan. Patients were included regardless of whether they underwent carotid endarterectomy (CEA). Results A total of 393 patients with CAS were included in the study; 133 (33.8%) underwent CEA and 260 (66.2%) were assigned to a conservative management (CM) group. In both groups of patients the prescription of platelet inhibitors, statins and antihypertensive drugs increased significantly (p < 0.001) after diagnosis. However treatment targets were not met in the majority of patients and the low-density lipoprotein level was on target in only 13.5% of patients. During follow-up, low-density lipoprotein levels were not measured in 19.8% of patients who underwent CEA and 44.2% of patients in the CM group (p < 0.001); HbA1c was not measured in 24.4% of patients with diabetes in the CEA group and in 18.8% of patients in the CM group (p = 0.560). There was no documentation of counselling on diet, exercise, smoking cessation or adherence to medication. The combined clinical event rate (all-cause mortality, cardiovascular mortality and non-fatal cardiovascular events) was high in both groups (CEA 36.8% and CM 36.9%; p = 1.00) with no difference in the occurrence of ipsilateral ischaemic stroke. Conclusions The clinical event rate was high in patients with high-grade CAS and the management of cardiovascular risk was deficient in all aspects.

  • 6.
    Johnsson, Per
    et al.
    Lund University Hospital, Sweden.
    Bäckström, Martin
    Lund University Hospital, Sweden.
    Bergh, Cecilia
    Lund University, Sweden.
    Jönsson, Henrik
    Lund University, Sweden.
    Lührs, Carsten
    Lund University, Sweden.
    Alling, Christer
    Lund University, Sweden.
    Increased S100B in blood after cardiac surgery is a powerful predictor of late mortality2003In: Annals of Thoracic Surgery, ISSN 0003-4975, E-ISSN 1552-6259, Vol. 75, no 1, p. 162-168Article in journal (Refereed)
    Abstract [en]

    BackgroundLong-term outcome in patients who suffered stroke after undergoing a cardiac operation has been investigated sparingly, but increased long-term mortality has been reported. S100B is a biochemical marker of brain cell ischemia and blood–brain barrier dysfunction. The aim of this investigation was to record the long-term mortality in consecutive patients undergoing cardiac operations and to explore whether increased concentrations of S100B in blood had a predictive value for mortality.MethodsProspectively collected clinical variables, including S100B, in 767 patients who survived more than 30 days after a cardiac operation, were analyzed with actuarial survival analysis and 678 patients were analyzed with Cox multiple regression analysis.ResultsForty-nine patients (6.4%) were dead at follow-up (range, 18 to 42 months); 11.5% (88 of 767 patients) had elevated S100B 2 days after operation (range, 38 to 42 hours). The probability for death at follow-up was 0.239 if the S100B level was more than 0.3 μg/L, and 0.041 if it was less than 0.3 μg/L. The clinical variables independently associated with mortality were preoperative renal failure, preoperative low left ventricular ejection fraction, emergency operation, severe postoperative central nervous system complication, and elevated S100B values, which turned out to be the most powerful predictor.ConclusionsEven slightly elevated S100B values in blood 2 days after cardiac operation imply a bad prognosis for outcome, and especially so in combination with any central nervous system complication.

  • 7. Jönsson, Henrik
    et al.
    Bergh, Cecilia
    Lunds universitet.
    Nielsen, Marie
    Bäckström, Martin
    Johnsson, Per
    God livskvalitet efter hjärtoperation. Bedöms lika av patient och anhörig.1999In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 96, no 47, p. 4p. 5233-5236Article in journal (Other academic)
  • 8.
    Jönsson, Henrik
    et al.
    University Hospital Lund, Sweden.
    Johnsson, Per
    University Hospital Lund, Sweden.
    Alling, Christer
    University Hospital Lund, Sweden.
    Bäckström, Martin
    University Hospital Lund, Sweden.
    Bergh, Cecilia
    University Hospital Lund, Sweden.
    Blomquist, Sten
    University Hospital Lund, Sweden.
    S100β after coronary artery surgery: release pattern, source of contamination, and relation to neuropsychological outcome1999In: Annals of Thoracic Surgery, ISSN 0003-4975, E-ISSN 1552-6259, Vol. 68, no 6, p. 2202-2208Article in journal (Refereed)
    Abstract [en]

    Background. S100β has been suggested as a marker of brain damage after cardiac operation. The aim of this study was to characterize the early S100β release in detail and relate it to neuropsychological outcome.

    Methods. Three groups of patients were investigated. All patients underwent coronary artery bypass surgery (CABG) with extracorporeal circulation. In group A, 110 patients had sampling of S100β for the first 10 postoperative hours and also underwent neuropsychological testing. In group B, 14 patients were examined for the effect of autotransfusion on S100β levels. Eight patients in group C had their intraoperative bleeding processed with a cell-saving device.

    Results. Group A had a heterogeneous release pattern with several rapid elevations in S100β concentration. In group B, high concentrations of S100β were found in the autotransfusion blood (range 0.2 to 210 μg/L) with a concurrent elevation of serum S100β levels after transfusion of shed blood. In group C, high levels of S100β were found in the blood from the surgical field (12.0 ± 6.0 μg/L) and decreased (1.1 ± 0.64 μg/L) after wash. Group C had significantly lower S100β values at the end of cardiopulmonary bypass compared to group A (0.53 ± 0.35 μg/L versus 2.40 ± 1.5 μg/L). S100β values were corrected for extracerebral contamination with a kinetic model. With this correction, an association was found between adverse neuropsychological outcome and S100β release in group A (r = 0.39, p < 0.02).

    Conclusions. A significant amount of S100β is found both in the blood from the surgical field and in the shed mediastinal blood postoperatively. Infusion of this blood will result in infusion of S100β into the blood and interfere in the interpretation of early systemic S100β values.Previous article in issue

  • 9.
    Jönsson, Henrik
    et al.
    Lund University Hospital, Sweden.
    Johnsson, Per
    Lund University Hospital, Sweden.
    Bäckström, Martin
    Lund University, Sweden.
    Alling, Christer
    Lund University Hospital, Sweden.
    Dautovic Bergh, Cecilia
    Lund University, Sweden.
    Blomquist, Sten
    Lund University Hospital, Sweden.
    Controversial significance of early S100B levels after cardiac surgery2004In: BMC Neurology, E-ISSN 1471-2377, Vol. 4, no 1, article id 24Article in journal (Refereed)
    Abstract [en]

    BackgroundThe brain-derived protein S100B has been shown to be a useful marker of brain injury of different etiologies. Cognitive dysfunction after cardiac surgery using cardiopulmonary bypass has been reported to occur in up to 70% of patients. In this study we tried to evaluate S100B as a marker for cognitive dysfunction after coronary bypass surgery with cardiopulmonary bypass in a model where the inflow of S100B from shed mediastinal blood was corrected for.

    Methods56 patients scheduled for coronary artery bypass grafting underwent prospective neuropsychological testing. The test scores were standardized and an impairment index was constructed. S100B was sampled at the end of surgery, hourly for the first 6 hours, and then 8, 10, 15, 24 and 48 hours after surgery. None of the patients received autotransfusion.

    ResultsIn simple linear analysis, no significant relation was found between S100B levels and neuropsychological outcome. In a backwards stepwise regression analysis the three variables, S100B levels at the end of cardiopulmonary bypass, S100B levels 1 hour later and the age of the patients were found to explain part of the neuropsychological deterioration (r = 0.49, p < 0.005).

    ConclusionsIn this study we found that S100B levels 1 hour after surgery seem to be the most informative. Our attempt to control the increased levels of S100B caused by contamination from the surgical field did not yield different results. We conclude that the clinical value of S100B as a predictive measurement of postoperative cognitive dysfunction after cardiac surgery is limited.

  • 10.
    Karlsson, Frida
    et al.
    Linnaeus University, Faculty of Health and Life Sciences, Department of Health and Caring Sciences.
    Matre, Anna
    Linnaeus University, Faculty of Health and Life Sciences, Department of Health and Caring Sciences.
    Bryr vi oss om ett litet hår i ditt sår?: En tvärsnittsstudie av personalens följsamhet till hygienriktlinjer under pågående operation2019Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Background: Florence Nightingale saved lives by keeping the environment clean before, during and after surgery in the mid-19th century. The knowledge in medicine has developed in exponential steps and the nursing care is trying to keep up. Studies show that compliance to hygiene guidelines are low. The routines to prevent surgical site infections need to be taken seriously, without exceptions, to prevent the infections to cause suffering both for individuals and the hospitals budgets. Aim: The purpose of this study was to study the OR staff´s compliance to hygiene guidelines at two south Swedish hospitals. Method: The study was a quantitative observational study. Data have been collected at two different southern Swedish hospitals during 152 surgeries. The observation was structured and followed a special protocol that observed if hair and beard is covered with a hood/other coverage and what type of shoes that the staff wear in the OR. It was also observed if surgeries that need ultraclean environment, as implant surgery, was respected with the extended guidelines. Results: The results showed that there where almost complete compliance to the hygiene guidelines during ultraclean surgeries. During other surgeries it showed that improvements could have been done by all staff in the OR. The staff that was working in the OR but not in the wound, close to the patient had lowest compliance. Conclusion: Knowledge and discipline to hygiene rules may lead to improvement in patient safety and diminished patient suffering.

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  • 11.
    Karlsson, Sara
    et al.
    University of Kalmar, School of Human Sciences.
    Löfberg, Hanna
    University of Kalmar, School of Human Sciences.
    Patienters oro i samband med dagkirurgi: - En litteraturstudie2009Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    På senare år har dagkirurgi blivit allt vanligare i Sverige. Dagkirurgi innebär att patienten kommer på morgonen för en planerad operation och får sedan gå hem igen, samma dag. Att bli opererad är ofta förknippat med oro för den som det berör. När denna oro inte blir tagen på allvar av sjukvårdspersonalen kan det leda till ett vårdlidande för patienten. Syftet med denna litteraturstudie var därför att belysa patienters oro i samband med dagkirurgi. Metod som användes var litteraturstudie och datasökning gjordes av publicerad klinisk omvårdnadsforskning, mellan åren 1995-2008, vilka motsvarade syftet. Sökningar gjordes i databaserna Cinahl, PsychINFO, PubMed och ELIN. Samtliga framtagna studier kvalitetsgranskades och resultatet bygger på 14 identifierade studier. Resultatet indelades i tre kategorier och visade att oro handlade om ovisshet inför vad som skulle hända. Orsaken berodde till stor del på bristande information och patienterna önskade både skriftlig och muntlig information. Brist på information resulterade i att patienterna kände sig övergivna. Det visade sig också att oro över att inte kunna påverka situationen och oro över illamående och smärta postoperativt, var vanligt förekommande. Slutsatsen påvisar vikten av information samt vikten av att sjuksköterskan finns till hands för patienten,

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  • 12.
    Nilsson, Gunilla
    Lunds universitet, medicinska fakulteten.
    Laparoscopic or Open Antireflux Surgery - A Comparative Study with Special Reference to the Patient´s Perspective2003Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The overall aim of this thesis was to compare the effects of laparoscopic versus open antireflux surgery in a randomized clinical trial focusing the patients&apos; subjective and objective outcome postoperatively, from a short-term and a long-term perspective. A further aim was to describe GORD patients&apos; experiences of illness and surgical treatment and if possible to find striking characteristics relating to laparoscopic or open surgery. Sixty patients with Gastro Oesophageal Reflux Disease (GORD) were randomized to laparoscopic or open 360º fundoplication. Subjective evaluations according to disease-specific and generic questionnaires, postoperative protocol, structured interviews, questionnaire and narratives as well as objective evaluations according to endoscopy, oesophageal manometry and 24-h pH monitoring were performed preoperatively, postoperatively, 1 month, 6 months and 5 years after surgery. Five patients were converted to open surgery. Two patients in the laparoscopic group were reoperated on because of hiatal strictures, one patient in the open group was reoperated on because of an incisional hernia and one patient in each group was operated on for having an intestinal obstruction. Operating time was longer for laparoscopic surgery 148 versus 109 minutes for open surgery (P<0.001), analgesics was less 33.9 versus 67.5 mg per total hospital stay for open surgery (P<0.001). Respiratory function was better in the laparoscopic group, FEV 2.6 versus 2.0 litres (P=0.008) and FVC 3.2 versus 2.2 litres (P=0.004); postoperative hospital stay was shorter 3 (2-6) versus 3 (2-10) days (P=0.021) for open surgery. No difference was found in sick leave between the groups. No differences were found in short- or long-term subjective outcomes in diet, sleep, medication, patient satisfaction and symptoms of GORD. Nor were there any differences found in short- or long-term objective outcomes from endoscopy, manometry or 24-h pH monitoring. Dysphagia, flatulence and difficulties to belch were new side-effects independent of type of surgery. Reasons for having surgery were a wish to avoid medication and to rid themselves of troubles and symptoms. All patients suffered from decreased well-being preoperatively that after surgery independent of invasiveness was restored back to or above norm values. Seven patients (25%) in the open group had complaints regarding the scar. The experts, the GORD patients themselves, described human responses to illness, surgical treatment and the outcome. No matter the type of invasiveness; elimination of the GORD symptoms led to increased well-being and for the majority of patients no need for daily acid-suppression medication. These results appeared one month after the operation and were still valid, five years after surgery.

  • 13.
    Nilsson, Gunilla
    University of Kalmar, School of Human Sciences.
    The patients´ perspective2006In: Gastroesophageal Reflux Disease: Principles of Disease, Diagnosis, and Treatment / [ed] Frank A Granderath, Thomas Kamolz, Rudolph Pointner, Wien: Springer-Verlag , 2006, p. 299-308Chapter in book (Other academic)
  • 14.
    Nilsson, Gunilla
    et al.
    Lunds universitet, medicinska fakulteten.
    Larsson, Sylvia
    Johnsson, Folke
    Randomized clinical trial of laparoscopic versus open fundoplication: blind evaluation of recovery and discharge period.2000In: British Journal of Surgery, ISSN 0007-1323, E-ISSN 1365-2168, Vol. 87, no 7, p. 873-878Article in journal (Refereed)
    Abstract [en]

    Background

    There is a widespread belief that introduction of the laparoscopic technique in antireflux surgery has led to easier postoperative recovery. To test this hypothesis a prospective randomized clinical trial with blind evaluation was conducted between laparoscopic and open fundoplication.

    Methods

    Sixty patients with gastro-oesophageal reflux disease were randomized to open or laparoscopic 360° fundoplication. The type of operation was unknown to the patient and the evaluating nurses after operation.

    Results

    The operating time was longer in the laparoscopy group, median 148 versus 109 min (P < 0·0001). The need for analgesics was less in the laparoscopically operated patients, 33·9 versus 67·5 mg morphine per total hospital stay (P < 0·001). There was no significant difference in postoperative nausea and vomiting. On the first day after operation patients in the laparoscopy group had better respiratory function: forced vital capacity 3·2 versus 2·2 litres (P = 0·004) and forced expiratory volume 2·6 versus 2·0 litres (P = 0·008). Postoperative hospital stay was shorter in the laparoscopic group, median (range) 3 (2–6) versus 3 (2–10) days (P = 0·021). No difference was found in the duration of sick leave.

    Conclusion

    Laparoscopic fundoplication was associated with a longer operating time, better respiratory function, less need for analgesics and a shorter hospital stay, while no reduction in the duration of postoperative sick leave was found compared with open surgery. © 2000 British Journal of Surgery Society Ltd

  • 15.
    Nilsson, Gunilla
    et al.
    Lunds universitet, medicinska fakulteten.
    Larsson, Sylvia
    Johnsson, Folke
    Randomized clinical trial of laparoscopic versus open fundoplication: evaluation of psychological well-being and changes in everyday life from a patient perspective2002In: Scandinavian Journal of Gastroenterology, ISSN 0036-5521, E-ISSN 1502-7708, Vol. 37, no 4, p. 385-91Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: The laparoscopic approach in antireflux surgery might have an impact on the patient's daily activities and well-being. METHODS: Sixty patients were randomized to laparoscopic or open 360 degrees fundoplication. Data were collected by questionnaires and interviews preoperatively, 1 month and 6 months after operation. RESULTS: Five patients in the laparoscopic group were converted to open surgery. Psychological general well-being increased after surgery and reached norm values in both study groups. No significant differences were found between the two types of surgery in the per protocol analysis, while the domain self-control was significantly better after open surgery in the intention-to-treat analysis. There was improvement of diet and sleep in both study groups; after 6 months, disturbed sleep was significantly more uncommon after open surgery. Dysphagia and flatulence were new symptoms that were reported after surgery. Overall perception of the results of the operation did not differ between the groups. CONCLUSIONS: Psychological general well-being, diet and sleep improved after both laparoscopic and open surgery. There were only small differences between the groups, but in some respects the results were better after open surgery.

  • 16.
    Nilsson, Gunilla
    et al.
    Lunds universitet, medicinska fakulteten.
    Wenner, Jörgen
    Larsson, Sylvia
    Johnsson, Folke
    Randomized clinical trial of laparoscopic versus open fundoplication for gastro-oesophageal reflux.2004In: British Journal of Surgery, ISSN 0007-1323, E-ISSN 1365-2168, Vol. 91, no 5, p. 552-9Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: The aim of this study was to compare the long-term results of laparoscopic and open antireflux surgery in a randomized clinical trial by investigating subjective and objective outcomes. METHODS: Sixty patients with gastro-oesophageal reflux disease (GORD) were randomized to laparoscopic or open 360 degrees fundoplication. Subjective evaluation using disease-specific and generic questionnaires and structured interviews, and objective evaluation by endoscopy, oesophageal manometry and 24-h pH monitoring, were performed before operation and 1 month, 6 months and 5 years after surgery. RESULTS: Two patients in the laparoscopic group had reoperations for hiatal stricture; one patient in the open group had repair of an incisional hernia, and one patient in each group had surgery for intestinal obstruction. There were no differences in the subjective outcomes of diet, sleep, medication, patient satisfaction and symptoms of GORD after 5 years. Nor were there any differences in objective outcomes determined by endoscopy, manometry or 24-h pH monitoring. Well-being was decreased in all patients before operation but was restored to normal or above-normal values after fundoplication, regardless of the type of surgery. Seven of 28 patients in the open group had complaints regarding the scar. CONCLUSION: Elimination of GORD symptoms improved well-being and eliminated the need for daily acid suppression in most patients, no matter which procedure was employed. These results were apparent 1 month after the operation and were still valid 5 years later.

  • 17.
    Qvistgaard, Maria
    et al.
    Linnaeus University, Faculty of Health and Life Sciences, Department of Health and Caring Sciences.
    Almerud Österberg, Sofia
    Linnaeus University, Faculty of Health and Life Sciences, Department of Health and Caring Sciences.
    Lovebo, Jenny
    Linnaeus University, Faculty of Health and Life Sciences, Department of Health and Caring Sciences.
    Covering surgical instruments with single- or double-layer drape pending surgery: an experimental study in a perioperative setting2021In: Journal of Infection Prevention, ISSN 1757-1774, Vol. 22, no 3, p. 126-131Article in journal (Refereed)
    Abstract [en]

    Background: Surgical site infections (SSI) constitute a severe threat to surgery patients. The surgical environment must be as free of contaminating microorganisms as possible. Using sterile surgical instruments while performing surgery is an absolute necessity for ensuring quality of care in perioperative settings.

    Aim: To compare bacterial contamination of agar plates after 15 h on set surgical instrument tables covered with a single- or double-layer drape.

    Methods: An experimental design was used consisting of set instrument tables with six agar plates on each table: four instrument tables were covered with a single-layer drape and four instrument tables were covered with a double-layer drape. This set-up was repeated on nine occasions during the period of data collection, making 76 set instrument tables in total. As a control, one instrument table was uncovered on four of those occasions.

    Results: The double-layer drape cover showed a significantly (P = 0.03) lower number of colony forming units (CFU) per agar plate than the single-layer drape covering. As expected, the uncovered instrument tables were highly contaminated.

    Discussion: Our results indicate that it is good practice to cover instruments properly with at least a single-layer drape before a surgical procedure. If there is difficulty achieving optimal conditions while setting the instrument tables (e.g. positioning the patient for general anaesthesia), it is a better option to set the instrument tables earlier and cover them with a double-layer drape. These precautions will help protect the patient from harm and unnecessary SSI by lowering microbiological burden, a key factor in developing SSI.

  • 18.
    Segernäs, Anna
    et al.
    Linköping University, Sweden.
    Skoog, Johan
    Linköping University, Sweden.
    Andersson, Eva Ahlgren
    Linköping University, Sweden.
    Almerud Österberg, Sofia
    Linnaeus University, Faculty of Health and Life Sciences, Department of Health and Caring Sciences. Regio Kronoberg, Sweden.
    Thulesius, Hans
    Linnaeus University, Faculty of Health and Life Sciences, Department of Medicine and Optometry. Lund University, Sweden.
    Zachrisson, Helene
    Linköping University, Sweden.
    Prediction of Postoperative Delirium After Cardiac Surgery with A Quick Test of Cognitive Speed, Mini-Mental State Examination and Hospital Anxiety and Depression Scale2022In: Clinical Interventions in Aging, ISSN 1176-9092, E-ISSN 1178-1998, Vol. 17, p. 359-368Article in journal (Refereed)
    Abstract [en]

    Purpose: To evaluate if preoperative assessment with A Quick Test of Cognitive Speed (AQT) could increase the accuracy of predicting delirium after cardiac surgery compared to Mini-Mental State Examination (MMSE), and examine if a composite of variables, including cognitive function and depressive symptoms, could be useful to predict delirium. Patients and Methods: Cardiac surgery was performed in 218 patients (mean age 72 years). Preoperative evaluation involved AQT, MMSE and Hospital Anxiety And Depression Scale (HADS). Postoperative delirium was assessed using Nursing Delirium Screening Scale (Nu-DESC) and Confusion Assessment Method-ICU (CAM-ICU). Logistic regression was performed to detect predictors of postoperative delirium and receiver operator characteristic curves (ROC) with area under the curve (AUC) to determine the accuracy. Results: Postoperative delirium occurred in 47 patients (22%) who had lower MMSE scores (median (range), 27 (19-30) vs 28 (20- 30), p=0.009) and slower AQT (median (range), 76 (48-181) vs 70 (40-182) seconds, p=0.030) than patients without delirium. Predictive power measured as AUC (95% CI) was 0.605 (0.51-0.70) for AQT and 0.623 (0.53-0.72) for MMSE. Logistic regression (OR, 95% CI) showed MMSE 27 points (2.72, 1.27-5.86), AQT 70 sec (2.26, 1.03-4.95), HADS-D >4 points (2.60, 1.21-5.58) and longer cardiopulmonary bypass-time (1.007, 1.002-1.013) to be associated with postoperative delirium. Combining these parameters yielded an AUC of 0.736 (0.65-0.82). Conclusion: The ability of predicting delirium using AQT was similar to MMSE, and only slightly higher by combining AQT and MMSE. Adding HADS-D and cardiopulmonary bypass-time to MMSE and AQT increased the predictive power to a borderline acceptable discriminatory value. Preoperative cognitive tests and screening for depressive symptoms may help identify patients at risk of postoperative delirium. Yet, there is still a need to establish useful preoperative tests.

  • 19.
    Sjödin, Joel
    et al.
    Linnaeus University, Faculty of Health and Life Sciences, Department of Medicine and Optometry.
    Gunnarsson, Jonatan
    Linnaeus University, Faculty of Health and Life Sciences, Department of Medicine and Optometry.
    Hur covid-19 påverkat utförda kataraktoperationer i Sverige under 2020 och 2021: En inblick från optikers perspektiv2022Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Background

    COVID-19 has affected our society and healthcare in a multifaceted way. One of the most common surgeries performed in Sweden today is cataract surgery. The average age of those who undergo cataract surgery reported to the National Cataract Registry is 73 years(Nationella kataraktregistret, 2020a). The Elderly have also been seen to be affected by Covid-19 to a greater extent than younger people (Modig et al., 2021). Optometrists perform the majority of eye examinations in Sweden (Optikerförbundet, 2020 referred in, European Council of Optometry and Optics, 2017), and it therefore stands to reason that they act as the primary screening pathway for patients with cataract in Sweden. With all this in mind, it is of interest to see how the volume of cataract surgery has been affected by the pandemic and how optometrists can help relieve the healthcare in future pandemics.

    Method

    This retrospective study analyzed data of performed cataract surgeries from the Swedish National Cataract Registry during the years 2019 to 2021 along with data from the Swedish Public Health Agency’s database SmiNet about newly registered COVID-19 cases.

    Results

    The total number of performed cataract surgeries during 2019 was 130 429, 115 970 during 2020 and 133 836 during 2021. The results from the analyses showed a lower operation volume during the first half of 2020. A positive correlation between infection rates and operation volumes were observed for both years. The reduction of performed surgeries could be seen to primarily occur in highly populated regions.

    Conclusion

    It is clear that an early affected cataract care has seen a quick recovery, but that the backlog of care still is not fully handled. Optometrists have had fewer patients during the pandemic and together with the rest of the eye-care system, can expect a greater number of patients with more developed problems as a consequence of the receding pandemic. It is therefore important to re-evaluate the handling of referrals in collaboration with eye-care centers and for optometrists to remain flexible in continually changing circumstances.

  • 20.
    Vilhelmsson, Maria
    et al.
    Linnaeus University, Faculty of Health and Life Sciences, Department of Health and Caring Sciences.
    Mortensen, Moa
    Linnaeus University, Faculty of Health and Life Sciences, Department of Health and Caring Sciences.
    Operationssjuksköterskans upplevelse av oväntade händelser på operationssalen: En kvalitativ intervjustudie.2020Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Abstract

    Background: The operating room is a high-tech and risky environment, where the patient is often in a vulnerable position. The operation nurse’s profession includes providing safe care to the patient which means, among other things, doing risk analyzes and working actively to prevent patient injuries. Although there are tools to ensure patient safety, such as the WHO Safe Surgery Checklist, unexpected events can occur. Unexpected events can involve arised errors and complications which can jeopardize the patient's safety.

    Aim: To investigate the operation theater nurse's experience of unexpected events in the operating room.

    Method: The study was a qualitative interview study conducted with semi-structured questions. A total of eight operating theater nurse’s were interviewed at two hospitals in southern Sweden. The interviews were analyzed with qualitative content analysis

    Result: Following the analysis three themes emerged that described how operating theatre nurses’ experienced unexpected events in the operating room; Feeling confident in oneself and others. The experience of preserving and losing control and Emotional aspects of unexpected events. How well-functioning the team is and the degree of professional experience are perceived to be key factors the influence how to handle an unexpected event. Mixed feelings such as inadequacy and stimulation in the profession emerged. 

    Conclusion: Operating theatre nurses generally feel secure when unexpected events occur. The study shows both positive and negative experiences in connection with an unexpected event. 

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  • 21. Wenner, Jörgen
    et al.
    Nilsson, Gunilla
    Lunds universitet, medicinska fakulteten.
    Öberg, Sven
    Melin, Tor
    Larsson, Sylvia
    Johnsson, Folke
    Short-term outcome after laparoscopic and open 360 degrees fundoplication. A prospective randomized trial.2001In: Surgical Endoscopy, ISSN 0930-2794, E-ISSN 1432-2218, Vol. 15, no 10, p. 1124-8Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Despite the lack of randomized trials supporting the laparoscopic approach, laparoscopic antireflux surgery has gained widespread acceptance during the last decade. The aim of this study was to compare the short-term symptomatic and objective outcome after laparoscopic and open 360 degrees fundoplication in a prospective randomized clinical trial. METHODS: Sixty patients with GERD were randomized to undergo either laparoscopic (LF) or open 360 degrees fundoplication (OF). Endoscopy, esophageal manometry, 24-h pH monitoring, clinical symptom evaluation, and symptom scoring according to a validated questionnaire (the Gastrointestinal Symptom Rating Scale [GSRS]) was performed preoperatively and 6 months after surgery. RESULTS: Five patients randomized to the laparoscopic group were converted to open surgery. Esophageal acid exposure was restored to normal in all patients. Lower esophageal sphincter length and resting pressure were significantly increased after both laparoscopic and open fundoplication (p < 0.001); there were no differences between the groups. No significant differences were seen in symptomatic outcome, although there was a trend toward a higher rate of mild dysphagia (p = 0.051) after laparoscopic surgery. GSRS revealed a decrease in reflux score (p < 0.001) and abdominal pain score (p < 0.001) postoperatively. There were no significant differences in GSRS scores between the two groups. CONCLUSION: Laparoscopic 360 degrees fundoplication is as effective in treating reflux disease as open fundoplication. Six months postoperatively, no significant differences were seen in symptomatic or objective outcome. Long-term evaluation is needed.

  • 22.
    Zineldin, Mosad
    et al.
    Linnaeus University, Faculty of Health and Life Sciences, Department of Medicine and Optometry.
    Hassan, Tamer
    Alexandria University, Egypt.
    Brain Arteriovenous Malformations (BAVMs) and Endovascular Catheter Embolization Treatment’s Safety and Complications2020In: Acta Scientific Neurology, E-ISSN 2582-1121, Vol. 3, no 2, p. 44-49Article in journal (Refereed)
    Abstract [en]

    Although endovascular catheter embolization (ECE) has been accepted as a therapeutic option for arteriovenous malformations (AVMs) in children and adolescents, considerable and substantial data are still lacking regarding the outcomes of CE for AVMs. This study aimed to clarify the outcomes and the complications of ECE for the treatment of AVM in patients aged less than 18 years.

      This study reports a case of an <18 years old patient who presented a year ago with headaches, weakness, back pain and sift nick. A year later the patient was subject to bleeding and a ECE was performed. Endovascular embolization was performed according to the procedures, guide and techniques for AVM embolization.

      Endovascular catheter embolization (ECE) of brain AVMS is relatively safe with low rate of complications if the patient had good or excellent outcomes at discharge after AVM embolization using right liquid embolic agents. Long term following up is needed to decrease the probability of the future complication and assure the patient safety.

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