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  • 1.
    Cwikiel, Magdalena
    et al.
    Department of Oncology, University Hospital, Lund. Sweden.
    Persson, Sylvi Ulrika
    Department of Internal Medicine, University Hospital, Lund, Sweden.
    Larsson, Hans
    Department of Internal Medicine, University Hospital, Lund, Sweden.
    Albertsson, Maria
    Department of Oncology, University Hospital, Lund. Sweden.
    Eskilsson, Jan
    Department of Cardiology, University Hospital, Lund. Sweden.
    Changes of blood viscosity in pateints treated with 5-fluorouracil: A link to cardiotoxicity?1995In: Acta Oncologica, ISSN 0284-186X, E-ISSN 1651-226X, Vol. 34, no 1, p. 83-85Article in journal (Refereed)
    Abstract [en]

    Abstract

     Cardiotoxicity is a serious but relatively unknown side-effect of treatment with 5-fluorouracil (5-FU). The underlying mechanism of 5-FU cardiotoxicity has not been defined. The aim of the present study was to determine whether hemorheological factors might in part explain 5-FU cardiotoxicity. Changes of blood and plasma viscosity, fibrinogen and hematocrit were studied in 11 patients treated by 5-FU.

    The study showed a decrease in blood and plasma viscosity during treatment with 5-FU, probably caused by a decrease of plasma fibrinogen. Reversible cardiotoxic effects were demonstrated in four patients.

  • 2.
    Sandgren, Anna
    et al.
    Linnaeus University, Faculty of Health, Social Work and Behavioural Sciences, School of Health and Caring Sciences. Region Kronoberg, Sweden.
    Fridlund, Bengt
    Linnaeus University, Faculty of Health, Social Work and Behavioural Sciences, School of Health and Caring Sciences. Jönköping university, Sweden.
    Nyberg, Per
    Lund university, Sweden.
    Strang, Peter
    Stockholms Sjukhems FoUU, Sweden;Karolinska Institutet.
    Petersson, Kerstin
    Region Kronoberg, Sweden.
    Thulesius, Hans
    Region Kronoberg, Sweden.
    Symptoms, care needs and diagnosis in palliative cancer patients in acute care hospitals: A 5-year follow-up survey2010In: Acta Oncologica, ISSN 0284-186X, E-ISSN 1651-226X, Vol. 49, no 4, p. 460-466(7)Article in journal (Refereed)
    Abstract [en]

    INTRODUCTION: Palliative cancer care in acute hospitals is scarcely studied. We therefore described and compared symptoms, care needs and types of cancer sites in 2002 compared to 2007 and analysed the relationships between these factors. METHODS: The study was population-based with a cross-sectional design and was carried out in medical, surgical and oncology wards in two acute care hospitals with no advanced palliative home care service. In 2002, 82 one-day-inventories were done (1 352 patients) compared to 142 one-day-inventories in 2007 (2 972 patients). Symptoms, care needs and cancer site were registered according to a questionnaire. Multiple logistic regression models were used to analyse associations between symptoms, care needs and cancer site. RESULTS: The proportion of palliative cancer patients had decreased during a five year period (14% vs. 11%, p<0.01). The patients were older in 2007 (74 vs. 70 years, p<0.001) and had more symptoms and care needs per patient (2.6 vs. 1.6, p<0.001). The most common symptoms were pain and deterioration and the most common cancer sites were prostate and colorectal cancer in both samples. Associations between symptoms, care needs and cancer site were mostly weak. Deterioration was associated with colorectal cancer, whereas pain was not associated with any specific cancer site. In haematological malignancies there was a high occurrence of infections and a high need of blood transfusions and infusions. Stomach/oesophagus cancers were significantly associated with nausea, nutritional problems and need of infusions while unknown primary malignancies were associated with abdominal surgery and infusions. DISCUSSION: Although we do not know all the causes for hospitalization, this study indicates that more focus should be on the symptoms instead of the specific cancer diagnosis. The findings also indicate that many palliative cancer patients' problems would be suitable for advanced palliative home care instead of acute hospital care.

  • 3.
    Thulesius, Hans
    et al.
    Region Kronoberg.
    Lindgren, Anna C
    Olsson, Håkan L
    Håkansson, Anders
    Diagnosis and prognosis of breast and ovarian cancer--a population-based study of 234 women.2004In: Acta Oncologica, ISSN 0284-186X, E-ISSN 1651-226X, Vol. 43, no 2, p. 175-81Article in journal (Refereed)
    Abstract [en]

    The diagnosis and prognosis for 135 women with breast cancer and 99 women with ovarian cancer in a well-defined geographical area, and a follow-up of 7-15 years are described, based on patients' records. Diagnosis was initiated in primary care for 53% of women with breast cancer, and for 57% of women with ovarian cancer. Median patient delay was 1 week for breast cancer, and 3.5 weeks for ovarian cancer patients, and median provider delay was 3 weeks for both groups. Crude, relative, and corrected 5-year survival was 73%, 91%, and 82% in breast cancer, and 40%, 49%, and 43% in ovarian cancer. Cox multiple regression analyses showed that stage IIIA and IV, and young age were associated with impaired disease-related survival in breast cancer. In patients with ovarian cancer, stages III and IV at diagnosis, old age, and systemic symptoms dominating at presentation were predictive of reduced disease-related survival while a family history of cancer was predictive of increased survival.

  • 4.
    Thulesius, Hans
    et al.
    Region Kronoberg.
    Pola, J
    Håkansson, A
    Diagnostic delay in pediatric malignancies--a population-based study.2000In: Acta Oncologica, ISSN 0284-186X, E-ISSN 1651-226X, Vol. 39, no 7, p. 873-6Article in journal (Refereed)
    Abstract [en]

    This study describes the discovery and diagnosis of malignant tumors from a primary care perspective in a Swedish county. Between 1984 and 1995, 68 children between the ages 0-16 years were diagnosed with a malignant tumor giving an incidence of 14/100,000. Patient records from both primary care and hospital were analyzed for 64 children. Leukemia was diagnosed in 25 children, and brain tumors in 22 children. In 68% of the children the diagnostic process was initiated in primary care, and in 32% in specialist care. Median parent's delay (time from first symptoms to first consultation), and median doctor's delay (time from first consultation to diagnosis) were 5 and 3 weeks for children with brain tumors, and 1 and 0 weeks for children with leukemia. Median lag time (parent's + doctor's delay) was 9 weeks for patients with brain tumors and 3 weeks for children with leukemia.

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