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  • 1.
    Islam, Mohammad Mirazul
    et al.
    Harvard Med Sch, USA.
    Sharifi, Roholah
    Harvard Med Sch, USA.
    Mamodaly, Shamina
    Harvard Med Sch, USA.
    Islam, Rakibul
    Univ Oslo, Norway;Oslo Univ Hosp, Norway.
    Nahra, Daniel
    Harvard Med Sch, USA.
    Abusamra, Dina B.
    Harvard Med Sch, USA.
    Hui, Pui Chuen
    Harvard Med Sch, USA.
    Adibnia, Yashar
    Harvard Med Sch, USA;Yeditepe Univ, Turkey.
    Goulamaly, Mehdi
    MIT, USA.
    Paschalis, Eleftherios I.
    Harvard Med Sch, USA.
    Cruzat, Andrea
    Harvard Med Sch, USA;Pontificia Univ Catolica Chile, Chile.
    Kong, Jing
    MIT, USA.
    Nilsson, Per H.
    Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences. Univ Oslo, Norway;Oslo Univ Hosp, Norway.
    Argileso, Pablo
    Harvard Med Sch, USA.
    Mollnes, Tom Eirik
    Univ Tromsö, Norway;Norwegian Univ Sci & Technol, Norway.
    Chodosh, James
    Harvard Med Sch, USA.
    Dohlman, Claes H.
    Harvard Med Sch, USA.
    Gonzalez-Andrades, Miguel
    Harvard Med Sch, USA;Reina Sofia Univ Hosp, Spain;Univ Cordoba, Spain.
    Effects of gamma radiation sterilization on the structural and biological properties of decellularized corneal xenografts2019In: Acta Biomaterialia, ISSN 1742-7061, E-ISSN 1878-7568, Vol. 96, p. 330-344Article in journal (Refereed)
    Abstract [en]

    To address the shortcomings associated with corneal transplants, substantial efforts have been focused on developing new modalities such as xenotransplantion. Xenogeneic corneas are anatomically and biomechanically similar to the human cornea, yet their applications require prior decellularization to remove the antigenic components to avoid rejection. In the context of bringing decellularized corneas into clinical use, sterilization is a crucial step that determines the success of the transplantation. Well-standardized sterilization methods, such as gamma irradiation (GI), have been applied to decellularized porcine corneas (DPC) to avoid graft-associated infections in human recipients. However, little is known about the effect of GI on decellularized corneal xenografts. Here, we evaluated the radiation effect on the ultrastructure, optical, mechanical and biological properties of DPC. Transmission electron microscopy revealed that gamma irradiated decellularized porcine cornea (G-DPC) preserved its structural integrity. Moreover, the radiation did not reduce the optical properties of the tissue. Neither DPC nor G-DPC led to further activation of complement system compared to native porcine cornea when exposed to plasma. Although, DPC were mechanically comparable to the native tissue, GI increased the mechanical strength, tissue hydrophobicity and resistance to enzymatic degradation. Despite these changes, human corneal epithelial, stromal, endothelial and hybrid neuroblastoma cells grew and differentiated on DPC and G-DPC. Thus, GI may achieve effective tissue sterilization without affecting critical properties that are essential for corneal transplant survival. (C) 2019 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

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