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  • 1.
    Adbo, Karina
    et al.
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Rosengren-Holmberg, Jenny
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Nicholls, Ian Alan
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Kinetics of enantioselective solid-phase extraction of Tröger’s base molecularly imprinted polymers2000Conference paper (Refereed)
  • 2. Bunk, R
    et al.
    Klinth, Jeanna
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Rosengren-Holmberg, Jenny
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Nicholls, Ian Alan
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Tågerud, Sven
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Omling, P
    Montelius, L
    Månsson, Alf
    University of Kalmar, School of Pure and Applied Natural Sciences.
    An ordered in vitro motility assay for the study of actomyosin interactions.2002Conference paper (Refereed)
  • 3. Bunk, R
    et al.
    Klinth, Jeanna
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Rosengren-Holmberg, Jenny
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Nicholls, Ian Alan
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Tågerud, Sven
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Omling, P
    Månsson, Alf
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Montelius, L
    Imprinted tracks for biochemically powered motor proteins2002Conference paper (Refereed)
  • 4. Bunk, R
    et al.
    Rosengren-Holmberg, Jenny
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Frölander, Kerstin
    Montelius, L
    Nicholls, Ian Alan
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Omling, P
    Tågerud, Sven
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Månsson, Alf
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Actomyosin motility on nanostructured resist polymers and silanes2003Conference paper (Refereed)
  • 5. Bunk, R
    et al.
    Rosengren-Holmberg, Jenny
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Nicholls, Ian Alan
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Tågerud, Sven
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Omling, P
    Månsson, Alf
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Montelius, L
    Imprinted tracks for biochemically powered motor proteins?2002Conference paper (Refereed)
  • 6. Bunk, R
    et al.
    Sundberg, Mark
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Rosengren-Holmberg, Jenny
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Carlberg, P
    Nicholls, Ian Alan
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Tågerud, Sven
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Omling, P
    Månsson, Alf
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Montelius, L
    A biomolecular nanoscale traffic system: Controlled motion of quantum dot labelled motor proteins2004Other (Other academic)
  • 7. Bunk, Richard
    et al.
    Klinth, Jeanna
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Rosengren-Holmberg, Jenny
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Nicholls, Ian Alan
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Tågerud, Sven
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Omling, Pär
    Månsson, Alf
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Montelius, Lars
    Towards a 'nano-traffic' system powered by molecular motors2003In: Microelectronic Engineering, Vol. 67-8, p. 899-904Article in journal (Refereed)
  • 8.
    Engberg, Anna E.
    et al.
    Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences. Region Skåne.
    Nilsson, Per H.
    Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences. Oslo Univ Hosp, Rikshosp, Norway;Univ Oslo, Norway.
    Huang, Shan
    Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences.
    Fromell, Karin
    Uppsala University.
    Hamad, Osama A.
    Uppsala University.
    Mollnes, Tom Eirik
    Univ Oslo, Norway;Univ Tromsö, Norway.
    Rosengren-Holmberg, Jenny P.
    Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences. Swedish Natl Lab Forens Sci, Linköping.
    Sandholm, Kerstin
    Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences.
    Teramura, Yuji
    Uppsala University;Univ Tokyo, Japan.
    Nicholls, Ian A.
    Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences. Uppsala University.
    Nilsson, Bo
    Uppsala University.
    Nilsson Ekdahl, Kristina
    Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences. Uppsala University.
    Prediction of inflammatory responses induced by biomaterials in contact with human blood using protein fingerprint from plasma2015In: Biomaterials, ISSN 0142-9612, E-ISSN 1878-5905, Vol. 36, p. 55-65Article in journal (Refereed)
    Abstract [en]

    Inappropriate complement activation is often responsible for incompatibility reactions that occur when biomaterials are used. Complement activation is therefore a criterion included in legislation regarding biomaterials testing. However, no consensus is yet available regarding appropriate complement-activation-related test parameters. We examined protein adsorption in plasma and complement activation/cytokine release in whole blood incubated with well-characterized polymers. Strong correlations were found between the ratio of C4 to its inhibitor C4BP and generation of 10 (mainly pro-inflammatory) cytokines, including IL-17, IFN-gamma, and IL-6. The levels of complement activation products correlated weakly (C3a) or not at all (C5a, sC5b-9), confirming their poor predictive values. We have demonstrated a direct correlation between downstream biological effects and the proteins initially adhering to an artificial surface after contact with blood. Consequently, we propose the C4/C4BP ratio as a robust, predictor of biocompatibility with superior specificity and sensitivity over the current gold standard. (C) 2014 Elsevier Ltd. All rights reserved.

  • 9.
    Engberg, Anna E.
    et al.
    Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences.
    Nilsson, Per H.
    Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences.
    Mollnes, Tom Eirik
    Rosengren-Holmberg, Jenny P.
    Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences.
    Nicholls, Ian A.
    Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences.
    Nilsson, Bo
    Nilsson Ekdahl, Kristina
    Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences.
    The ratio between C4 and C4BP adsorbed from plasma predicts cytokine generation induced by artificial polymers in contact with whole blood2012In: Immunobiology, ISSN 0171-2985, E-ISSN 1878-3279, Vol. 217, no 11, p. 1211-1211Article in journal (Other academic)
  • 10.
    Engberg, Anna E.
    et al.
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Rosengren-Holmberg, Jenny
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Nicholls, Ian A.
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Nilsson Ekdahl, Kristina
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Development of novel biomaterial surfaces and evaluation of their hemocompatibility*2008In: Journal of Molecular Immunology 45, 2008Conference paper (Refereed)
  • 11.
    Engberg, Anna E.
    et al.
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Rosengren-Holmberg, Jenny
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Nicholls, Ian A.
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Nilsson Ekdahl, Kristina
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Development of novel biomaterial surfaces and evaluation of their hemocompatibility2008Conference paper (Refereed)
  • 12.
    Engberg, Anna E.
    et al.
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Rosengren-Holmberg, Jenny P.
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Nilsson Ekdahl, Kristina
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Nicholls, Ian A.
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Synthesis of new polymers and evaluation of their hemocompatibility2009Conference paper (Refereed)
  • 13.
    Engberg, Anna E.
    et al.
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Rosengren-Holmberg, Jenny P
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Nilsson, Per H.
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Bäck,
    Department of Oncology, Radiology and Clinical Immunology, Section of Clinical Immunology, Rudbeck Laboratory C5, Uppsala University Hospital, SE-751 85 Uppsala, Sweden.
    Mollnes, Tom Eirik
    Institute of Immunology, Rikshospitalet University Hospital, Oslo, Norway,Research Laboratory, Nordland Hospital, Bodø, and University of Tromsø, Norway.
    Nicholls, Ian A.
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Nilsson, Bo
    Department of Oncology, Radiology and Clinical Immunology, Section of Clinical Immunology, Rudbeck Laboratory C5, Uppsala University Hospital, SE-751 85 Uppsala, Sweden.
    Nilsson Ekdahl, Kristina
    University of Kalmar, School of Pure and Applied Natural Sciences.
    EVALUATION OF THE HEMOCOMPATIBILITY OF NOVEL POLYMERIC MATERIALSManuscript (preprint) (Other academic)
    Abstract [en]

    When a biomaterial surface comes in contact with blood an immediate adsorption of plasma proteins to the surface will occur, and the cascade systems in the blood, such as the complement, coagulation and contact system, will be activated to various degrees. The intensity of this reaction will determine the hemocompatibility of the materials. Here we present an evaluation of the link between the composition, the physico-chemical properties and the protein adsorption properties of six newly synthesized polymers (P1-P6) and the hemocompatibility.The hemocompatibility of the polymeric surfaces was evaluated in human blood plasma and whole blood. Commercially available polyvinylchloride (PVC) was used as reference material. The hemocompatibility of the polymeric surfaces was evaluated with regard to complement activation (C3a and sC5-9 generation) and coagulation activation (platelet loss and TAT-formation) and cytokine productions (27 analytes in multiplex assay) after contact with whole blood. Contact activation was quantified by analyses of FXIIa-C1INH, FXIa-C1INH, and kallikrein-C1INH complexes.Polymers P2 (p<0.05 for C3a), P3, P5 and P6 showed less complement activation, and polymers P1 and P4 (p<0.05 for platelet loss), as well as P5 and P6 showed less coagulation activation compared with reference PVC. Polymers P1-P3 induced activation of the contact system, P3 being the most potent. Secretion of 17 cytokines including chemokines and growth factors were differentially influenced by the polymers, P1 and P3 being significantly (p<0.05) more compatible for five of the analytes.Collectively these data demonstrate that the composition of the polymers clearly leads to different biological properties as a consequence of distinctive physico-chemical properties and protein adsorption patterns.1

  • 14.
    Hedin-Dahlström, Jimmy
    et al.
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Rosengren-Holmberg, Jenny
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Legrand, Sacha
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Wikman, Susanne
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Nicholls, Ian Alan
    University of Kalmar, School of Pure and Applied Natural Sciences.
    A class II aldolase mimic2006In: Journal of organic chemistry, Vol. 71, no 13, p. 4845-4853Article in journal (Refereed)
  • 15.
    Hedin-Dahlström, Jimmy
    et al.
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Rosengren-Holmberg, Jenny
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Legrand, Sacha
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Wikman, Susanne
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Nicholls, Ian Alan
    University of Kalmar, School of Pure and Applied Natural Sciences.
    A class II aldolase mimic2006Conference paper (Refereed)
  • 16.
    Karlsson, Jesper G
    et al.
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Rosengren-Holmberg, Jenny
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Nicholls, Ian Alan
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Enantioselective synthetic thalidomide receptors based upon DNA binding motifs2006Conference paper (Refereed)
  • 17.
    Klinth, Jeanna
    et al.
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Bunk, R
    Rosengren-Holmberg, Jenny
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Montelius, L
    Nicholls, Ian Alan
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Tågerud, Sven
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Omling, P
    Månsson, Alf
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Reconstruction of motor protein order and function outside the living cell2002Conference paper (Refereed)
  • 18. Montelius, L
    et al.
    Bunk, R
    Sundberg, Mark
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Rosengren-Holmberg, Jenny
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Carlberg, P
    Nicholls, Ian Alan
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Tågerud, Sven
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Omling, P
    Månsson, Alf
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Fabrication and characterization of fully biocompatible nanostructured surfaces allowing functional studies of molecular motors2004Other (Other academic)
  • 19.
    Månsson, Alf
    et al.
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Bunk, R
    Sundberg, Mark
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Rosengren-Holmberg, Jenny
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Nicholls, Ian Alan
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Omling, P
    Tågerud, Sven
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Montelius, L
    Motor protein function on nanostructured surfaces2003Other (Other academic)
  • 20.
    Månsson, Alf
    et al.
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Bunk, Richard
    Sundberg, Mark
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Balaz, Martina
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Lindahl, Joakim
    Nicholls, Ian Alan
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Omling, Pär
    Rosengren-Holmberg, Jenny
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Tågerud, Sven
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Montelius, Lars
    Molecular motors show their muscles in nanotechnology2004In: SPIE Nanotechnology Electronic Newsletter, Vol. June, p. 7-8Article in journal (Refereed)
  • 21.
    Månsson, Alf
    et al.
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Sundberg, Mark
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Bunk, R
    Balaz, Martina
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Rosengren-Holmberg, Jenny
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Lindahl, Joakim
    Nicholls, Ian Alan
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Tågerud, Sven
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Omling, P
    Montelius, L
    Silane micropatterns with motor proteins for creation of spatiotemporal chemical gradients on a chip2004Other (Other academic)
  • 22.
    Nicholls, Ian A.
    et al.
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Adbo, Karina
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Andersson, Håkan S.
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Andersson, Per-Ola
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Ankarloo, Jonas
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Hedin-Dahlström, Jimmy
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Jokela, Päivi
    University of Kalmar, School of Communication and Design.
    Karlsson, Jesper G.
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Olofsson, Linus
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Rosengren-Holmberg, Jenny
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Shoravi, Siamak
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Svenson, Johan
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Wikman, Susanne
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Can we rationally design molecularly imprinted polymers?2001In: Analytica Chimica Acta, Vol. 435, no 1, p. 9-18Article in journal (Refereed)
  • 23.
    Nicholls, Ian A.
    et al.
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Karlsson, Björn C. G.
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Andersson, Håkan S.
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Golker, Kerstin
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Henschel, Henning
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Olsson, Gustaf D.
    University of Kalmar, School of Pure and Applied Natural Sciences.
    O'Mahony, John
    Nilsson Ekdahl, Kristina
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Orozovic, Kanita
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Rosengren, Annika M.
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Rosengren-Holmberg, Jenny P.
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Shoravi, Siamak
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Wiklander, Jesper G.
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Wikman, Susanne
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Biomimetic Polymer Design2009Conference paper (Refereed)
  • 24.
    Nicholls, Ian Alan
    et al.
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Månsson, Alf
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Sundberg, Mark
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Bunk, R
    Balaz, Martina
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Rosengren-Holmberg, Jenny
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Lindahl, Joakim
    Tågerud, Sven
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Omling, P
    Montelius, L
    Nanotechnology, surface science and actomyosin motility in vitro2004Conference paper (Refereed)
  • 25.
    Nicholls, Ian Alan
    et al.
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Rosengren-Holmberg, Jenny
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Molecule selective surfaces2002In: Bioseparation, Vol. 10, p. 301-305Article in journal (Refereed)
  • 26.
    Nilsson Ekdahl, Kristina
    et al.
    Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences.
    Engberg, Anna E.
    Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences.
    Rosengren-Holmberg, Jenny P.
    Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences.
    Chen, H
    University of Pennsylvania.
    Lambris, JD
    University of Pennsylvania.
    Nicholls, Ian A.
    Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences.
    Blood protein-polymer adsorption fingerprinting: Implications for understanding hemoocompatibility and for biomaterial design.2011In: Journal of Biomedical Materials Research. Part A, ISSN 1549-3296, E-ISSN 1552-4965, Vol. 97A, no 1, p. 74-84Article in journal (Refereed)
  • 27.
    Rosengren-Holmberg, Jenny
    et al.
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Karlsson, Jesper G
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Nicholls, Ian Alan
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Enantioselective synthetic thalidomide receptors based upon DNA binding motifs2004In: Organic & Biomolecular Chemistry, Vol. 2, no 22, p. 3374-3378Article in journal (Refereed)
  • 28.
    Rosengren-Holmberg, Jenny
    et al.
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Karlsson, Jesper G
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Nicholls, Ian Alan
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Enantioselective synthetic thalidomide respectors based upon DNA binding motifs2004Conference paper (Refereed)
  • 29.
    Rosengren-Holmberg, Jenny
    et al.
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Karlsson, Jesper G
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Nicholls, Ian Alan
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Molecularly imprinted polymers for the teratogenic substance (S)-Thalidomide2002Conference paper (Refereed)
  • 30.
    Rosengren-Holmberg, Jenny
    et al.
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Karlsson, Jesper G
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Svenson, Johan
    Nicholls, Ian Alan
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Paracetamol selective synthetic antibodies2008Conference paper (Refereed)
  • 31.
    Rosengren-Holmberg, Jenny P.
    et al.
    Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences. Swedish Natl Forens Ctr, Sweden.
    Andersson, Jonas
    Univ Uppsala Hosp, Sweden.
    Smith, James R.
    Univ Portsmouth, UK.
    Alexander, Cameron
    Univ Nottingham, UK.
    Alexander, Morgan R.
    Univ Nottingham, UK.
    Tovar, Guenter
    Univ Stuttgart, Germany;Fraunhofer Inst Interfacial Engn & Biotechnol, Germany.
    Nilsson Ekdahl, Kristina
    Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences. Univ Uppsala Hosp, Sweden.
    Nicholls, Ian A.
    Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences. Uppsala University.
    Heparin molecularly imprinted surfaces for the attenuation of complement activation in blood2015In: Biomaterials Science, ISSN 2047-4830, E-ISSN 2047-4849, Vol. 3, no 8, p. 1208-1217Article in journal (Refereed)
    Abstract [en]

    Heparin-imprinted synthetic polymer surfaces with the ability to attenuate activation of both the complement and the coagulation system in whole blood were successfully produced. Imprinting was achieved using a template coated with heparin, a highly sulfated glycosaminoglycan known for its anticoagulant properties. The N,N'-diacryloylpiperazine-methacrylic acid copolymers were characterized using goniometry, AFM and XPS. The influence of the molecular imprinting process on morphology and template rebinding was demonstrated by radioligand binding assays. Surface hemocompatibility was evaluated using human whole blood without anticoagulants followed by measurement of complement activation markers C3a and sC5b-9 and platelet consumption as a surrogate coagulation activation marker. The observed low thrombogenicity of this copolymer combined with the attenuation of complement activation induced by the molecular imprint offer potential for the development of self-regulating surfaces with important potential clinical applications. We propose a mechanism for the observed phenomena based upon the recruitment of endogenous sulfated glycosaminoglycans with heparin-like activities.

  • 32.
    Rosengren-Holmberg, Jenny P.
    et al.
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Karlsson, Jesper G.
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Svenson, Johan
    Andersson, Håkan S.
    Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences.
    Nicholls, Ian A.
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Synthesis and ligand recognition of paracetamol selective polymers: semi-covalent versus non-covalent molecular imprinting.2009In: Organic and biomolecular chemistry, ISSN 1477-0520, E-ISSN 1477-0539, Vol. 7, p. 3148-3155Article in journal (Refereed)
    Abstract [en]

    Three molecular imprinting strategies, each based upon a series of ethylene glycol dimethacrylate (EGDMA) cross-linked co-polymers, have been used to produce materials selective for the commonly used analgesic and antipyretic agent paracetamol (p-acetaminophen or 4-acetamidophenol) (1). The polymers were synthesised using either a semi-covalent imprinting strategy based upon 4-acetamidophenyl-(4-vinylphenyl) carbonate (4) or a non-covalent strategy based on methacrylic acid (MAA) as the functional monomer, or by employing a combination of these strategies. Radioligand binding studies demonstrated low template affinity in polymers offering only a single electrostatic interaction point for recognition via the phenolic residue in the template, whereas binding was substantially increased upon the introduction of a second binding mode, namely interaction at the acetamide moiety. HPLC analyses revealed no imprinting effect in the purely semi-covalent system, and only a minor effect in the purely non-covalent systems. However, a pronounced imprinting effect was demonstrated for polymers prepared by a combination of semi-covalent and non-covalent imprinting. This study illustrates a limitation of both the non-covalent and the semi-covalent strategies when it comes to achieving imprinted selectivity for small and poorly functionalised templates such as paracetamol. Parallels with conclusions from studies with antibodies are discussed. 

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