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  • 1. Brand, S J
    et al.
    Morise, Z
    Tågerud, Sven
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Mazzola, L
    Granger, D N
    Grisham, M B
    Role of the proteasome in indomethacin-induced gastropathy1999Inngår i: Gastroenterology, Vol. 116, s. 865-873Artikkel i tidsskrift (Fagfellevurdert)
  • 2. Brand, S J
    et al.
    Tågerud, Sven
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Lambert, P
    Magil, S G
    Tatarkiewicz, K
    Doiron, K
    Yan, Y
    Pharmacological treatment of chronic diabetes by stimulating pancreatic beta-cell regeneration with systemic co-administration of EGF and gastrin2002Inngår i: Pharmacology & Toxicology, Vol. 91, s. 414-420Artikkel i tidsskrift (Fagfellevurdert)
  • 3. Bunk, R
    et al.
    Klinth, Jeanna
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Rosengren-Holmberg, Jenny
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Nicholls, Ian Alan
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Tågerud, Sven
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Omling, P
    Montelius, L
    Månsson, Alf
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    An ordered in vitro motility assay for the study of actomyosin interactions.2002Konferansepaper (Fagfellevurdert)
  • 4. Bunk, R
    et al.
    Klinth, Jeanna
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Rosengren-Holmberg, Jenny
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Nicholls, Ian Alan
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Tågerud, Sven
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Omling, P
    Månsson, Alf
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Montelius, L
    Imprinted tracks for biochemically powered motor proteins2002Konferansepaper (Fagfellevurdert)
  • 5. Bunk, R
    et al.
    Rosengren-Holmberg, Jenny
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Frölander, Kerstin
    Montelius, L
    Nicholls, Ian Alan
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Omling, P
    Tågerud, Sven
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Månsson, Alf
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Actomyosin motility on nanostructured resist polymers and silanes2003Konferansepaper (Fagfellevurdert)
  • 6. Bunk, R
    et al.
    Rosengren-Holmberg, Jenny
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Nicholls, Ian Alan
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Tågerud, Sven
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Omling, P
    Månsson, Alf
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Montelius, L
    Imprinted tracks for biochemically powered motor proteins?2002Konferansepaper (Fagfellevurdert)
  • 7. Bunk, R
    et al.
    Sundberg, Mark
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Rosengren-Holmberg, Jenny
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Carlberg, P
    Nicholls, Ian Alan
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Tågerud, Sven
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Omling, P
    Månsson, Alf
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Montelius, L
    A biomolecular nanoscale traffic system: Controlled motion of quantum dot labelled motor proteins2004Annet (Annet vitenskapelig)
  • 8. Bunk, Richard
    et al.
    Carlberg, P
    Månsson, Alf
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Nicholls, Ian Alan
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Omling, Pär
    Sundberg, Mark
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Tågerud, Sven
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Montelius, Lars
    Guiding molecular motors with nano-imprinted structures2005Inngår i: Japanese journal of applied physics. Part 1, Regular papers, short notes & review papers, Vol. 44 (5A), s. 3337-3340Artikkel i tidsskrift (Fagfellevurdert)
  • 9. Bunk, Richard
    et al.
    Klinth, Jeanna
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Montelius, Lars
    Nicholls, Ian Alan
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Omling, Pär
    Tågerud, Sven
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Månsson, Alf
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Actomyosin motility on nanostructured surfaces2003Inngår i: Biochemical and Biophysical Research Communications, Vol. 301, s. 783-788Artikkel i tidsskrift (Fagfellevurdert)
  • 10. Bunk, Richard
    et al.
    Klinth, Jeanna
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Rosengren-Holmberg, Jenny
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Nicholls, Ian Alan
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Tågerud, Sven
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Omling, Pär
    Månsson, Alf
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Montelius, Lars
    Towards a 'nano-traffic' system powered by molecular motors2003Inngår i: Microelectronic Engineering, Vol. 67-8, s. 899-904Artikkel i tidsskrift (Fagfellevurdert)
  • 11. Bunk, Richard
    et al.
    Sundberg, Mark
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Månsson, Alf
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Nicholls, Ian Alan
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Omling, Pär
    Tågerud, Sven
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Montelius, Lars
    Guiding motor-propelled molecules with nanoscale precision through silanized bi-channel structures2005Inngår i: Nanotechnology, Vol. 16 (6), s. 710-717Artikkel i tidsskrift (Fagfellevurdert)
  • 12.
    Ekman, Elisabet
    et al.
    Linnéuniversitetet, Fakultetsnämnden för naturvetenskap och teknik, Institutionen för naturvetenskap, NV.
    Petersson, Göran
    Linnéuniversitetet, Fakultetsnämnden för hälsa, socialt arbete och beteendevetenskap, Institutionen för hälso- och vårdvetenskap, HV.
    Tågerud, Sven
    Linnéuniversitetet, Fakultetsnämnden för naturvetenskap och teknik, Institutionen för naturvetenskap, NV.
    Bäckström, Martin
    Awareness among nurses about reporting of adverse drug reactions in Sweden2012Inngår i: Drug, Healthcare and Patient Safety, ISSN 1179-1365, E-ISSN 1179-1365, Vol. 4, s. 61-66Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: The purpose of this study was to investigate awareness among nurses regarding their new role as reporters of adverse drug reactions in Sweden and factors that may influence reporting by nurses.

    Methods: In 2007, all nurses were included in the adverse drug reaction reporting scheme in Sweden. A questionnaire was sent to 753 randomly selected nurses in September 2010.

    Results: Of the 453 (60%) responding nurses, 265 (58%) were aware that nurses were included in the reporting of adverse drug reactions. Sixty-one nurses (14%) stated that they had reported an adverse drug reaction. Fifteen percent (n = 70) of the respondents had received training about reporting of adverse drug reactions. Almost one third of these (n = 21, 30%) had reported an adverse drug reaction on at least one occasion. Among nurses without training, a smaller proportion (n = 40, 11%, P < 0.05) had reported an adverse drug reaction on at least one occasion. The two factors considered most important by nurses for reporting were the severity of the adverse drug reaction and if the reaction was to a newly approved drug. A majority of the nurses (n = 397, 88%) were interested in a training course in pharmacology as part of their ongoing professional development. One third (32%) of all nurses stated that one reason for not reporting a suspected adverse drug reaction was that the physician responsible did not regard the reaction necessary to report.

    Conclusion: We found that more than half of the study population of nurses in Sweden were aware of their new role as reporters of adverse drug reactions, but few of the responding nurses had reported an adverse drug reaction. Given that training seems to be associated with high reporting frequency, we suggest more training in pharmacovigilance for nurses.

  • 13. Elmquist, S
    et al.
    Libelius, Rolf
    Lawoko, G
    Tågerud, Sven
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Dextrans as markers for endocytosis in innervated and denervated skeletal muscle1992Inngår i: Muscle & Nerve, Vol. 15, s. 876-884Artikkel i tidsskrift (Fagfellevurdert)
  • 14.
    Evertsson, Kim
    et al.
    Linnéuniversitetet, Fakulteten för Hälso- och livsvetenskap (FHL), Institutionen för kemi och biomedicin (KOB).
    Fjällström, Ann-Kristin
    Linnéuniversitetet, Fakulteten för Hälso- och livsvetenskap (FHL), Institutionen för kemi och biomedicin (KOB).
    Norrby, Marlene
    Linnéuniversitetet, Fakulteten för Hälso- och livsvetenskap (FHL), Institutionen för kemi och biomedicin (KOB).
    Tågerud, Sven
    Linnéuniversitetet, Fakulteten för Hälso- och livsvetenskap (FHL), Institutionen för kemi och biomedicin (KOB).
    p38 mitogen-activated protein kinase and mitogen-activated protein kinase-activated protein kinase 2 (MK2) signaling in atrophic and hypertrophic denervated mouse skeletal muscle2014Inngår i: Journal of Molecular Signaling, ISSN 1750-2187, E-ISSN 1750-2187, Vol. 9, nr 2Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    BACKGROUND: p38 mitogen-activated protein kinase has been implicated in both skeletal muscle atrophy and hypertrophy. T317 phosphorylation of the p38 substrate mitogen-activated protein kinase-activated protein kinase 2 (MK2) correlates with muscle weight in atrophic and hypertrophic denervated muscle and may influence the nuclear and cytoplasmic distribution of p38 and/or MK2. The present study investigates expression and phosphorylation of p38, MK2 and related proteins in cytosolic and nuclear fractions from atrophic and hypertrophic 6-days denervated skeletal muscles compared to innervated controls.

    METHODS: Expression and phosphorylation of p38, MK2, Hsp25 (heat shock protein25rodent/27human, Hsp25/27) and Hsp70 protein expression were studied semi-quantitatively using Western blots with separated nuclear and cytosolic fractions from innervated and denervated hypertrophic hemidiaphragm and atrophic anterior tibial muscles. Unfractionated innervated and denervated atrophic pooled gastrocnemius and soleus muscles were also studied.

    RESULTS: No support was obtained for a differential nuclear/cytosolic localization of p38 or MK2 in denervated hypertrophic and atrophic muscle. The differential effect of denervation on T317 phosphorylation of MK2 in denervated hypertrophic and atrophic muscle was not reflected in p38 phosphorylation nor in the phosphorylation of the MK2 substrate Hsp25. Hsp25 phosphorylation increased 3-30-fold in all denervated muscles studied. The expression of Hsp70 increased 3-5-fold only in denervated hypertrophic muscles.

    CONCLUSIONS: The study confirms a differential response of MK2 T317 phosphorylation in denervated hypertrophic and atrophic muscles and suggests that Hsp70 may be important for this. Increased Hsp25 phosphorylation in all denervated muscles studied indicates a role for factors other than MK2 in the regulation of this phosphorylation.

  • 15.
    Fjällström, Ann-Kristin
    et al.
    Linnéuniversitetet, Fakulteten för Hälso- och livsvetenskap (FHL), Institutionen för kemi och biomedicin (KOB).
    Evertsson, Kim
    Linnéuniversitetet, Fakulteten för Hälso- och livsvetenskap (FHL), Institutionen för kemi och biomedicin (KOB).
    Norrby, Marlene
    Linnéuniversitetet, Fakulteten för Hälso- och livsvetenskap (FHL), Institutionen för kemi och biomedicin (KOB).
    Tågerud, Sven
    Linnéuniversitetet, Fakulteten för Hälso- och livsvetenskap (FHL), Institutionen för kemi och biomedicin (KOB).
    Forkhead box O1 and muscle RING finger 1protein expression in atrophic and hypertrophicdenervated mouse skeletal muscle2014Inngår i: Journal of Molecular Signaling, ISSN 1750-2187, E-ISSN 1750-2187, Vol. 9, artikkel-id 9Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: Forkhead box O (FoxO) transcription factors and E3 ubiquitin ligases such as Muscle RING finger 1 (MuRF1) are believed to participate in the regulation of skeletal muscle mass. The function of FoxO transcription factors is regulated by post-translational modifications such as phosphorylation and acetylation. In the present study FoxO1 protein expression, phosphorylation and acetylation as well as MuRF1 protein expression, were examined in atrophic and hypertrophic denervated skeletal muscle. Methods: Protein expression, phosphorylation and acetylation were studied semi-quantitatively using Western blots. Muscles studied were 6-days denervated mouse hind-limb muscles (anterior tibial as well as pooled gastrocnemius and soleus muscles, all atrophic), 6-days denervated mouse hemidiaphragm muscles (hypertrophic) and innervated control muscles. Total muscle homogenates were used as well as separated nuclear and cytosolic fractions of innervated and 6-days denervated anterior tibial and hemidiaphragm muscles. Results: Expression of FoxO1 and MuRF1 proteins increased 0.3-3.7-fold in all 6-days denervated muscles studied, atrophic as well as hypertrophic. Phosphorylation of FoxO1 at S256 increased about 0.8-1-fold after denervation in pooled gastrocnemius and soleus muscles and in hemidiaphragm but not in unfractionated anterior tibial muscle. A small (0.2-fold) but statistically significant increase in FoxO1 phosphorylation was, however, observed in cytosolic fractions of denervated anterior tibial muscle. A statistically significant increase in FoxO1 acetylation (0.8-fold) was observed only in denervated anterior tibial muscle. Increases in total FoxO1 and in phosphorylated FoxO1 were only seen in cytosolic fractions of denervated atrophic anterior tibial muscle whereas in denervated hypertrophic hemidiaphragm both total FoxO1 and phosphorylated FoxO1 increased in cytosolic as well as in nuclear fractions. MuRF1 protein expression increased in cytosolic as well as in nuclear fractions of both denervated atrophic anterior tibial muscle and denervated hypertrophic hemidiaphragm muscle. Conclusions: Increased expression of FoxO1 and MuRF1 in denervated muscles (atrophic as well as hypertrophic) suggests that these proteins participate in the tissue remodelling occurring after denervation. The effect of denervation on the level of phosphorylated and acetylated FoxO1 differed in the muscles studied and may be related to differences in fiber type composition of the muscles.

  • 16.
    Fjällström, Ann-Kristin
    et al.
    Linnéuniversitetet, Fakulteten för Hälso- och livsvetenskap (FHL), Institutionen för kemi och biomedicin (KOB).
    Norrby, Marlene
    Linnéuniversitetet, Fakulteten för Hälso- och livsvetenskap (FHL), Institutionen för kemi och biomedicin (KOB).
    Tågerud, Sven
    Linnéuniversitetet, Fakulteten för Hälso- och livsvetenskap (FHL), Institutionen för kemi och biomedicin (KOB).
    Expression and phosphorylation of eukaryotic translation initiation factor 4-gamma (eIF4G) in denervated atrophic and hypertrophic mouse skeletal muscle2015Inngår i: Cell Biology International, ISSN 1065-6995, E-ISSN 1095-8355, Vol. 39, nr 4, s. 496-501Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The eukaryotic translation initiation factor 4-gamma (eIF4G) is important for the initiation of protein synthesis and phosphorylation on S1108 regulates this function of eIF4G. Thus, increased phosphorylation has been reported in conditions associated with increased protein synthesis such as meal feeding and insulin/IGF-1 treatment whereas decreased phosphorylation occurs following starvation, dexamethasone treatment, in sepsis and in atrophic denervated hind-limb muscle. The aim of the present study was to test the hypothesis that S1108 phosphorylation of eIF4G is differentially affected in denervated atrophic hind-limb muscles and denervated hypertrophic hemidiaphragm muscle. Protein expression and phosphorylation in innervated and 6-days denervated atrophic hind-limb muscles (pooled gastrocnemius and soleus) and hypertrophic hemidiaphragms were studied semi-quantitatively using Western blots. Total expression of eIF4G did not change in denervated hind-limb muscles but increased about 77% in denervated hemidiaphragm. S1108 phosphorylated eIF4G decreased about 64% in denervated hind-limb muscles but increased about 1.3-fold in denervated hemidiaphragm. The ratio of S1108 phosphorylated eIF4G to total eIF4G decreased about 60% in denervated hind-limb muscles but no statistically significant change was observed in denervated hemidiaphragm. The differential effect of denervation on eIF4G expression and S1108 phosphorylation in hemidiaphragm (hypertrophic) and hind-limb muscle (atrophic) may represent a regulatory mechanism that helps clarify the differential response of these muscles following denervation.

  • 17.
    Gierow, Peter
    et al.
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Sjögren, Elsie
    Magnusson, Caroline
    Tågerud, Sven
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Cloning, partial sequencing and expression of rabbit lacrimal gland beta-hexosaminidase2002Inngår i: Advances in Experimental Medicine and Biology, Vol. 506(pt A), s. 33-39Artikkel i tidsskrift (Fagfellevurdert)
  • 18.
    Hovstadius, Bo
    et al.
    Linnéuniversitetet, Fakultetsnämnden för naturvetenskap och teknik, Institutionen för naturvetenskap, NV.
    Tågerud, Sven
    Linnéuniversitetet, Fakultetsnämnden för naturvetenskap och teknik, Institutionen för naturvetenskap, NV.
    Petersson, Göran
    Linnéuniversitetet, Fakultetsnämnden för hälsa, socialt arbete och beteendevetenskap, Institutionen för hälso- och vårdvetenskap, HV.
    Åstrand, Bengt
    Linnéuniversitetet, Fakultetsnämnden för naturvetenskap och teknik, Institutionen för naturvetenskap, NV.
    Prevalence and therapeutic intensity of dispensed drug groups for individuals with multiple medications: a register-based study of 2.2 million individuals2010Inngår i: Journal of Pharmaceutical Health Services Research, ISSN 1759-8885, Vol. 1, nr 4, s. 145-155Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objectives  To assess the prevalence and the therapeutic intensity of dispensed drug groups for individuals receiving multiple medications.

    Methods  The individual-based data of all dispensed outpatient prescriptions in Sweden in 2006 were analysed. Five or more dispensed drugs (DP ≥ 5) during a 12-month period were applied as an indicator of multiple medications. The drugs were categorized according to the second level of the World Health Organization's Anatomic, Therapeutic, Chemical classification. The defined daily dosage per individual during 12 months was applied as an indicator of the therapeutic intensity.

    Key findings  For the 2.2 million individuals with DP ≥ 5, the drug groups with the highest prevalences were antibacterials (48.2%), analgesics (40.3%), psycholeptics (35.9%), antithrombotic agents (33.4%) and beta-blocking agents (31.7%). As examples, the level of prevalence increased with age for analgesics, psycholeptics, antithrombotic agents and diuretics, and decreased with age for antibacterials, drugs for obstructive airway diseases and antihistamines for systemic use. Substantial differences in the level of prevalence between women and men were observed for several drug groups; for example, thyroid therapy (13.3 vs 3.6%), psychoanaleptics (26.3 vs 18.2%), drugs used in diabetes (9.1 vs 15.7%) and lipid-modifying agents (18.1 vs 30.7%). Generally, the therapeutic intensity increased with the increasing number of dispensed drugs. For a third of the most common drug groups, the therapeutic intensity increased with an increasing age above the 60–69-year age group.

    Conclusion  The number of drugs taken not only increases the potential risks associated with multiple drug use, but also increases the potential burden of an increased therapeutic intensity, especially for older people. The reported findings may enlighten physicians and healthcare stakeholders concerning the complex patterns of multiple drug use in the entire population and the associated expenses. The findings may also be used as a base for interventions aiming to bring about the most appropriate and balanced prescription of medicines to individuals with multiple diseases.

  • 19. Höcker, M
    et al.
    Zhang, Z
    Fenstermacher, D A
    Tågerud, Sven
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Chulak, M
    Joseph, D
    Wang, T C
    Rat histidine decarboxylase promoter is regulated by gastrin through a protein kinase C pathway1996Inngår i: American Journal of Physiology, Vol. 270, s. G619-G633Artikkel i tidsskrift (Fagfellevurdert)
  • 20.
    Klinth, Jeanna
    et al.
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Bunk, R
    Rosengren-Holmberg, Jenny
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Montelius, L
    Nicholls, Ian Alan
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Tågerud, Sven
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Omling, P
    Månsson, Alf
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Reconstruction of motor protein order and function outside the living cell2002Konferansepaper (Fagfellevurdert)
  • 21. Lawoko, G
    et al.
    Tågerud, Sven
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    High endocytotic activity occurs periodically in the endplate region of denervated mouse striated muscle fibres1995Inngår i: Experimental Cell Research, Vol. 219, s. 598-603Artikkel i tidsskrift (Fagfellevurdert)
  • 22. Lawoko, G
    et al.
    Tågerud, Sven
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Libelius, Rolf
    Increased endocytotic and lysosomal activities in denervated type I and type II muscle fibres1992Inngår i: Histochemistry, Vol. 97, s. 221-224Artikkel i tidsskrift (Fagfellevurdert)
  • 23. Libelius, Rolf
    et al.
    Lundquist, I
    Tågerud, Sven
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Thesleff, S
    Endocytosis and lysosomal enzyme activities in dystrophic muscle: The effect of denervation1981Inngår i: Acta Physiologica Scandinavica, Vol. 113, nr 2, s. 259-261Artikkel i tidsskrift (Fagfellevurdert)
  • 24. Libelius, Rolf
    et al.
    Tågerud, Sven
    Department of Pharmacology, University of Lund.
    Uptake of horseradish peroxidase in denervated skeletal muscle occurs primarily at the endplate region1984Inngår i: Journal of the Neurological Sciences, ISSN 0022-510X, E-ISSN 1878-5883, Vol. 66, s. 273-281Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The spatial distribution of horseradish peroxidase (HRP) uptake has been studied by light- and electron microscopy in the denervated hemidiaphragm of the mouse. Segments with high HRP uptake were observed in a band centrally located in the denervated muscle. This distribution is similar to the well-known innervation pattern of the diaphragm. Ultrastructural studies demonstrated a high incidence of postsynaptic folds in close proximity of fibre areas with high intracellular content of HRP. 8–12 days after denervation a large number of fibres showed segments of high HRP uptake. 2–4 days after denervation very few such segments were observed. Biochemical studies also demonstrated an increase in HRP uptake after denervation occurring primarily in the endplate region. The activities of the lysosomal enzymes N-acetyl-β-d-glucosaminidase, acid phosphatase and cathepsin D all increased after denervation, most prominently in the endplate region.It is suggested that the observed segmental uptake of HRP and lysosomal activation reflects a process for rapid membrane turnover in denervated muscle. 

  • 25. Magnusson, Caroline
    et al.
    Högklint, Lars
    Libelius, Rolf
    Tågerud, Sven
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Expression of mRNA for plasminogen activators and protease nexin-1 in innervated and denervated mouse skeletal muscle2001Inngår i: Journal of Neuroscience research, Vol. 66, s. 457-463Artikkel i tidsskrift (Fagfellevurdert)
  • 26. Magnusson, Caroline
    et al.
    Svensson, Anna
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Christersson, Ulrika
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Tågerud, Sven
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Denervation-induced alterations in gene expression in mouse skeletal muscle2005Inngår i: European journal of neuroscience, Vol. 21 (2), s. 577-580Artikkel i tidsskrift (Fagfellevurdert)
  • 27. Montelius, L
    et al.
    Bunk, R
    Sundberg, Mark
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Rosengren-Holmberg, Jenny
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Carlberg, P
    Nicholls, Ian Alan
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Tågerud, Sven
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Omling, P
    Månsson, Alf
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Fabrication and characterization of fully biocompatible nanostructured surfaces allowing functional studies of molecular motors2004Annet (Annet vitenskapelig)
  • 28.
    Månsson, Alf
    et al.
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Bunk, R
    Sundberg, Mark
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Rosengren-Holmberg, Jenny
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Nicholls, Ian Alan
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Omling, P
    Tågerud, Sven
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Montelius, L
    Motor protein function on nanostructured surfaces2003Annet (Annet vitenskapelig)
  • 29.
    Månsson, Alf
    et al.
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Bunk, Richard
    Sundberg, Mark
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Balaz, Martina
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Lindahl, Joakim
    Nicholls, Ian Alan
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Omling, Pär
    Rosengren-Holmberg, Jenny
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Tågerud, Sven
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Montelius, Lars
    Molecular motors show their muscles in nanotechnology2004Inngår i: SPIE Nanotechnology Electronic Newsletter, Vol. June, s. 7-8Artikkel i tidsskrift (Fagfellevurdert)
  • 30.
    Månsson, Alf
    et al.
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Nicholls, Ian Alan
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Omling, P
    Tågerud, Sven
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Montelius, L
    Nanotechnology enhanced functional assays of actomyosin motility - Potentials and challenges2007Inngår i: Controlled nanoscale motion : Nobel symposium 131 / [ed] H. Linke and Månsson A., Springer, Berlin: Lecture Notes in Physics , 2007, s. 385-406Kapittel i bok, del av antologi (Annet vitenskapelig)
  • 31.
    Månsson, Alf
    et al.
    Linnéuniversitetet, Fakultetsnämnden för naturvetenskap och teknik, Institutionen för naturvetenskap, NV.
    Norrby, Marlene
    Linnéuniversitetet, Fakultetsnämnden för naturvetenskap och teknik, Institutionen för naturvetenskap, NV.
    Tågerud, Sven
    Linnéuniversitetet, Fakultetsnämnden för naturvetenskap och teknik, Institutionen för naturvetenskap, NV.
    Molecular Motors and Self-Healing at the Neuromuscular Synapse2011Inngår i: Self-Healing at the Nanoscale: Mechanisms and Key Concepts of Natural and Artificial Systems / [ed] Vincenzo Amendola & Moreno Meneghetti, CRC Press, 2011, 1, s. 357-394Kapittel i bok, del av antologi (Annet vitenskapelig)
  • 32.
    Månsson, Alf
    et al.
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Sundberg, Mark
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Balaz, Martina
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Bunk, Richard
    Nicholls, Ian Alan
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Omling, Pär
    Tågerud, Sven
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Montelius, Lars
    In vitro sliding of actin filaments labelled with single quantum dots2004Inngår i: Biochemical and Biophysical Research Communications, Vol. 314, s. 529-534Artikkel i tidsskrift (Fagfellevurdert)
  • 33.
    Månsson, Alf
    et al.
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Sundberg, Mark
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Bunk, R
    Balaz, Martina
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Nicholls, Ian Alan
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Tågerud, Sven
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Omling, P
    Montelius, L
    Nanotechnology based confinement and rectification of motor protein function - relation to intracellular transport and implications for drug screening2004Konferansepaper (Fagfellevurdert)
  • 34.
    Månsson, Alf
    et al.
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Sundberg, Mark
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Bunk, R
    Balaz, Martina
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Nicholls, Ian Alan
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Tågerud, Sven
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Omling, P
    Montelius, L
    Nanotechnology based confinement, guidance and rectification of actin filament slidin2004Annet (Annet vitenskapelig)
  • 35.
    Månsson, Alf
    et al.
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Sundberg, Mark
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Bunk, R
    Balaz, Martina
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Rosengren-Holmberg, Jenny
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Lindahl, Joakim
    Nicholls, Ian Alan
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Tågerud, Sven
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Omling, P
    Montelius, L
    Silane micropatterns with motor proteins for creation of spatiotemporal chemical gradients on a chip2004Annet (Annet vitenskapelig)
  • 36.
    Månsson, Alf
    et al.
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Sundberg, Mark
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Bunk, Richard
    Balaz, Martina
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Nicholls, Ian Alan
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Omling, Pär
    Tegenfeldt, J O
    Tågerud, Sven
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Montelius, Lars
    Actin-based molecular motors for cargo transportation in nanotechnology - Potentials and challenges2005Inngår i: IEEE transactions on advanced packaging, Vol. 28 (4), s. 547-555Artikkel i tidsskrift (Fagfellevurdert)
  • 37.
    Månsson, Alf
    et al.
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Sundberg, Mark
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Bunk, Richard
    Balaz, Martina
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Nicholls, Ian Alan
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Tågerud, Sven
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Omling, Pär
    Montelius, Lars
    Nanotechnology-based confinement, guidance and rectification of actin filament sliding2004Inngår i: Journal of Muscle Research & Cell Motility, Vol. 25Artikkel i tidsskrift (Fagfellevurdert)
  • 38.
    Månsson, Alf
    et al.
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Tågerud, Sven
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Känslig detektion av gifter, patogener och sjukdomsmarkörer genom aggregation av cytoskeletala filament.2006Patent (Annet (populærvitenskap, debatt, mm))
  • 39.
    Månsson, Alf
    et al.
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Tågerud, Sven
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Multivariate statistics in analysis of data from the in vitro motility assay2003Inngår i: Analytical Biochemistry, Vol. 314 (2), s. 281-293Artikkel i tidsskrift (Fagfellevurdert)
  • 40.
    Månsson, Alf
    et al.
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Tågerud, Sven
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Sundberg, Mark
    Rosengren, Jenny P
    Montelius, Lars
    Omling, P
    Bunk, R
    Lindahl, J
    Nicholls, Ian A.
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Balaz, Martina
    Drug screening method, uses nanotechnology to apply motor protein filaments to loading zones on chip and immobilised motor proteins to propel them into nanochannels2004Patent (Annet (populærvitenskap, debatt, mm))
  • 41.
    Månsson, Alf
    et al.
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Tågerud, Sven
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Sundberg, Mark
    Rosengren, Jenny P
    Montelius, Lars
    Omling, P
    Bunk, R
    Lindahl, J
    Nilsson, L
    Nicholls, Ian A
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Balaz, Martina
    Drug screening method, uses nanotechnology to apply motor protein filaments to loading zones on chip and immobilised motor proteins to propel them into nanochannels2007Patent (Annet (populærvitenskap, debatt, mm))
  • 42.
    Nicholls, Ian Alan
    et al.
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Månsson, Alf
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Sundberg, Mark
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Bunk, R
    Balaz, Martina
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Rosengren-Holmberg, Jenny
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Lindahl, Joakim
    Tågerud, Sven
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Omling, P
    Montelius, L
    Nanotechnology, surface science and actomyosin motility in vitro2004Konferansepaper (Fagfellevurdert)
  • 43. Norell, M C
    et al.
    Tågerud, Sven
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Nicholls, Ian Alan
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    The kinetics of dissociation from molecularly imprinted polymer synthetic theophylline receptors1997Konferansepaper (Fagfellevurdert)
  • 44.
    Norrby, Marlene
    et al.
    Linnéuniversitetet, Fakultetsnämnden för naturvetenskap och teknik, Institutionen för naturvetenskap, NV.
    Evertsson, Kim
    Linnéuniversitetet, Fakultetsnämnden för naturvetenskap och teknik, Institutionen för naturvetenskap, NV.
    Fjällström, Ann-Kristin
    Linnéuniversitetet, Fakultetsnämnden för naturvetenskap och teknik, Institutionen för naturvetenskap, NV.
    Svensson, Anna
    Tågerud, Sven
    Linnéuniversitetet, Fakultetsnämnden för naturvetenskap och teknik, Institutionen för naturvetenskap, NV.
    Akt (protein kinase B) isoform phosphorylation and signaling downstream of mTOR (mammalian target of rapamycin) in denervated atrophic and hypertrophic mouse skeletal muscle.2012Inngår i: Journal of Molecular Signaling, ISSN 1750-2187, E-ISSN 1750-2187, Vol. 7, nr June, s. Article ID: 7-Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    ABSTRACT: BACKGROUND: The present study examines the hypothesis that Akt (protein kinase B)/mTOR (mammalian target of rapamycin) signaling is increased in hypertrophic and decreased in atrophic denervated muscle. Protein expression and phosphorylation of Akt1, Akt2, glycogen synthase kinase-3beta (GSK-3beta), eukaryotic initiation factor 4E binding protein 1 (4EBP1), 70 kD ribosomal protein S6 kinase (p70S6K1) and ribosomal protein S6 (rpS6) were examined in six-days denervated mouse anterior tibial (atrophic) and hemidiaphragm (hypertrophic) muscles. RESULTS: In denervated hypertrophic muscle expression of total Akt1, Akt2, GSK-3beta, p70S6K1 and rpS6 proteins increased 2-10 fold whereas total 4EBP1 protein remained unaltered. In denervated atrophic muscle Akt1 and Akt2 total protein increased 2-16 fold. A small increase in expression of total rpS6 protein was also observed with no apparent changes in levels of total GSK-3beta, 4EBP1 or p70S6K1 proteins. The level of phosphorylated proteins increased 3-13 fold for all the proteins in hypertrophic denervated muscle. No significant changes in phosphorylated Akt1 or GSK-3beta were detected in atrophic denervated muscle. The phosphorylation levels of Akt2, 4EBP1, p70S6K1 and rpS6 were increased 2-18 fold in atrophic denervated muscle. CONCLUSIONS: The results are consistent with increased Akt/mTOR signaling in hypertrophic skeletal muscle. Decreased levels of phosphorylated Akt (S473/S474) were not observed in denervated atrophic muscle and results downstream of mTOR indicate increased protein synthesis in denervated atrophic anterior tibial muscle as well as in denervated hypertrophic hemidiaphragm muscle. Increased protein degradation, rather than decreased protein synthesis, is likely to be responsible for the loss of muscle mass in denervated atrophic muscles.

  • 45.
    Norrby, Marlene
    et al.
    Linnéuniversitetet, Fakultetsnämnden för naturvetenskap och teknik, Institutionen för naturvetenskap, NV.
    Tågerud, Sven
    Linnéuniversitetet, Fakultetsnämnden för naturvetenskap och teknik, Institutionen för naturvetenskap, NV.
    Mitogen-activated protein kinase-activated protein kinase 2 (MK2) in skeletal muscle atrophy and hypertrophy2010Inngår i: Journal of Cellular Physiology, ISSN 0021-9541, E-ISSN 1097-4652, Vol. 223, nr 1, s. 194-201Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Skeletal muscle is a highly plastic tissue. Overall muscle growth (hypertrophy) or muscle wasting (atrophy) results from alterations in intracellular signaling pathways with important regulatory steps occurring in the nucleus as well as in the cytoplasm. Previous studies have identified components of the Akt/mTor pathway as well as the p38 MAPK pathway as important for skeletal muscle hypertrophy and/or atrophy. The present study tests the hypothesis that MK2, a substrate of p38 which following phosphorylation, can be exported from the nucleus in a complex with p38, may be important for skeletal muscle growth. The expression of MK2 was examined in denervated mouse hind-limb (atrophic) and hemidiaphragm (transiently hypertrophic) muscles. MK2 mRNA expression decreased after denervation in both atrophic (48% of innervated controls, P < 0.001) and hypertrophic muscle (34% of innervated controls, P < 0.01) but MK2 protein expression decreased only in atrophic muscle (32% of innervated controls, P < 0.01). The level of T205 phosphorylated MK2 increased after denervation in both atrophic (fourfold increase, P < 0.01) and hypertrophic muscles (almost sevenfold increase, P < 0.001) whereas the level of T317 phosphorylated MK2 (necessary for nuclear export) increased after denervation in hypertrophic muscle (nearly threefold increase, P < 0.001) but not in atrophic muscle. Logarithmically transformed relative changes in MK2 phosphorylated at T317 correlated well (r2 = 0.7737) with relative changes in muscle weight. The results suggest a role for MK2 in the regulation of muscle mass, a role which, at least in part, may be related to determining the subcellular localization of p38 in muscle fibers. J. Cell. Physiol. 223: 194–201,

  • 46. Rohsenow, DJ
    et al.
    Minsky, S
    Snöberg, Jan
    Högskolan i Kalmar, Sjöfartshögskolan.
    Tågerud, Sven
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Hunt, SK
    Almeida, A
    Greece, J
    Allensworth-Davies, D
    The effects of transdermal scopolamine on simulated ship navigation and attention/reaction time2008Inngår i: International journal of occupational and environmental health, ISSN 1077-3525, E-ISSN 2049-3967, Vol. 14, s. 250-256Artikkel i tidsskrift (Fagfellevurdert)
  • 47. Sellin, L C
    et al.
    Libelius, Rolf
    Lundquist, I
    Tågerud, Sven
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Thesleff, S
    Membrane and biochemical alterations after denervation and during reinnervation of mouse skeletal muscle1980Inngår i: Acta Physiologica Scandinavica, Vol. 110, nr 2, s. 181-186Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Denervation of the extensor digitorum longus (EDL) muscle of the mouse by either nerve crush or nerve section produced: a reduction of the resting membrane potential (Em), alterations in the properties of muscle fibre action potentials and the development of tetrodotoxin (TTX)-resistant action potentials. These changes in membrane electrical properties were accompanied by an increase in the endocytic activity of the muscle and an increase in the activities of the lysosomal enzymes cathepsin D and N-acetylglucosaminidase (NAGA). Reinnervation of muscle was indicated at 9 days after nerve crush by the presence of miniature end-plate potentials. The recovery of membrane electrical properties, beginning with the onset of reinnervation, were not temporally related. The Em increased in two stages: an early rapid repolarization and a later slower repolarization. The muscle fibers were sensitive to the blocking action of TTX by 12 days after nerve crush, whereas the rate of rise (dV/dt) of the action potential did not approach values of innervated muscles until 21 days. Reinnervation resulted in a decrease in endocytosis and a decrease in the activities of cathepsin D and NAGA toward innervated values by 21 days after nerve crush. The results suggest that membrane alterations after denervation and during reinnervation may occur by endo- and exocytosis of membrane constituents and that the lysosomal system may play a role in the breakdown and/or recycling of these structures. 

  • 48.
    Semark, Birgitta
    et al.
    Linnéuniversitetet, Fakulteten för Hälso- och livsvetenskap (FHL), Institutionen för medicin och optometri (MEO).
    Brudin, Lars
    Linköpings universitet.
    Tågerud, Sven
    Linnéuniversitetet, Fakulteten för Hälso- och livsvetenskap (FHL), Institutionen för kemi och biomedicin (KOB).
    Petersson, Göran
    Linnéuniversitetet, Fakulteten för Hälso- och livsvetenskap (FHL), Institutionen för medicin och optometri (MEO).
    Peterson, Ulla
    Linnéuniversitetet, Fakulteten för Hälso- och livsvetenskap (FHL), Institutionen för hälso- och vårdvetenskap (HV).
    Self-rated health and educational level among elderly with depressive and physical disordersManuskript (preprint) (Annet vitenskapelig)
    Abstract [en]

    Aim: Poor self-rated health (SRH) among elderly has been suggested to be more closely related to mental than to physical disorders. The aim was to investigate the association between SRH in elderly and depressive and physical disorders in relation to age, sex and educational level.

    Methods: A cross-sectional study was conducted using a questionnaire sent to a randomised Swedish sample of individuals aged 65-80 years with a response rate of 67% (n= 6659). SRH in relation to age, sex, education, depressive symptoms, hypertension, diabetes and asthma was calculated by univariate and multivariate logistic regressions analyses.

    Results: There was an association between good SRH and not feeling depressed (OR 9.4), to not having hypertension (OR 1.6), diabetes (OR 2.8), or asthma (OR 2.1). SRH was rated as less good with higher age. SRH was rated as better with higher educational levels and men rated their health as better than women did. The association to depressive symptoms, hypertension, diabetes and asthma were lower with higher educational level and varied with sex.

    Conclusion: Poor SRH in elderly was associated with depressive symptoms, hypertension, diabetes and asthma with the strongest association to depressive symptoms. Thus, SRH might serve as a valuable complement to other diagnostic methods in the health care of the elderly, as it also can provide health information beyond classical risk factors or medical history.

  • 49.
    Semark, Birgitta
    et al.
    Linnéuniversitetet, Fakulteten för Hälso- och livsvetenskap (FHL), Institutionen för hälso- och vårdvetenskap (HV).
    Engström, Sven
    Brudin, Lars
    Linköpings universitet.
    Tågerud, Sven
    Linnéuniversitetet, Fakulteten för Hälso- och livsvetenskap (FHL), Institutionen för kemi och biomedicin (KOB).
    Fredlund, Kerstin
    Borgquist, Lars
    Linköpings universitet.
    Petersson, Göran
    Linnéuniversitetet, Fakulteten för Hälso- och livsvetenskap (FHL), Institutionen för medicin och optometri (MEO).
    Factors influencing the prescription of drugs of different price levels2013Inngår i: Pharmacoepidemiology and Drug Safety, ISSN 1053-8569, E-ISSN 1099-1557, Vol. 22, nr 3, s. 286-293Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Purpose Socioeconomic factors have been suggested to influence the prescribing of newer and more expensive drugs. In the present study, individual and health care provider factors were studied in relation to the prevalence of differently priced drugs. Methods Register data for dispensed drugs were retrieved for 18486 individuals in a county council in Sweden. The prevalence of dispensed drugs was combined with data for the individual's gender, age, education, income, foreign background, and type of caregiver. For each of the diagnostic groups (chronic obstructive pulmonary disease [COPD], depression, diabetes, and osteoporosis), selected drugs were dichotomized into cost categories, lower and higher price levels. Univariate and multivariate logistic regressions were performed using cost category as the dependent variable and the individual and provider factors as independent variables. Results In all four diagnostic groups, differences were observed in the prescription of drugs of lower and higher price levels with regard to the different factors studied. Age and gender affected the prescription of drugs of lower and higher price levels more generally, except for gender in the osteoporosis group. Income, education, foreign background, and type of caregiver affected prescribing patterns but in different ways for the different diagnostic groups. Conclusions Certain individual and provider factors appear to influence the prescribing of drugs of different price levels. Because the average price for the cheaper drugs versus more costly drugs in each diagnostic group was between 19% and 69%, there is a risk that factors other than medical needs are influencing the choice of drug. Copyright (c) 2013 John Wiley & Sons, Ltd.

  • 50. Sharp, R
    et al.
    Babyatsky, M W
    Takagi, H
    Tågerud, Sven
    Högskolan i Kalmar, Naturvetenskapliga institutionen.
    Wang, T C
    Bockman, D E
    Brand, S J
    Merlino, G
    Transforming growth factor-alfa disrupts the normal program of cellular differentiation in the gastric mucosa of transgenic mice1995Inngår i: Development, Vol. 121, s. 149-161Artikkel i tidsskrift (Fagfellevurdert)
12 1 - 50 of 76
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