lnu.sePublications
Change search
Refine search result
1234567 101 - 150 of 606
CiteExportLink to result list
Permanent link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Rows per page
  • 5
  • 10
  • 20
  • 50
  • 100
  • 250
Sort
  • Standard (Relevance)
  • Author A-Ö
  • Author Ö-A
  • Title A-Ö
  • Title Ö-A
  • Publication type A-Ö
  • Publication type Ö-A
  • Issued (Oldest first)
  • Issued (Newest first)
  • Created (Oldest first)
  • Created (Newest first)
  • Last updated (Oldest first)
  • Last updated (Newest first)
  • Disputation date (earliest first)
  • Disputation date (latest first)
  • Standard (Relevance)
  • Author A-Ö
  • Author Ö-A
  • Title A-Ö
  • Title Ö-A
  • Publication type A-Ö
  • Publication type Ö-A
  • Issued (Oldest first)
  • Issued (Newest first)
  • Created (Oldest first)
  • Created (Newest first)
  • Last updated (Oldest first)
  • Last updated (Newest first)
  • Disputation date (earliest first)
  • Disputation date (latest first)
Select
The maximal number of hits you can export is 250. When you want to export more records please use the Create feeds function.
  • 101. Boij, Roland
    et al.
    Svensson, Judit
    Nilsson Ekdahl, Kristina
    Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences.
    Sandholm, Kerstin
    Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences.
    Lindahl, Tomas
    Palonek, Elzbieta
    Garle, Mats
    Berg, Mats
    Ernerudh, Jan
    Jenmalm, Mats
    Matthiesen, Leif
    Biomarkers of coagulation, inflammation and angiogenesis are independently associated with preeclampsia2012In: American Journal of Reproductive Immunology and Microbiology, ISSN 8755-8920, Vol. 68, no 3, p. 258-270Article in journal (Refereed)
    Abstract [en]

    Problem Although preeclampsia has been associated with inflammation, coagulation, and angiogenesis, their correlation and relative contribution are unknown. Method of Study About 114 women with preeclampsia, 31 with early onset (EOP) and 83 with late onset preeclampsia (LOP), and 100 normal pregnant controls were included. A broad panel of 32 biomarkers reflecting coagulation, inflammation, and angiogenesis was analyzed. Results Preeclampsia was associated with decreased antithrombin, IL-4 and placental growth factor levels and with increased C3a, pentraxin-3, and sFlt-1 levels, with more marked differences in the EOP group. The Th1-associated chemokines CXCL10 and CXCL11 were significantly higher in the preeclampsia and EOP group than in controls, respectively. No correlations between the biomarkers were found in preeclampsia. Multivariate logistic regression tests confirmed the results. Conclusions Cytokines, chemokines and complement activation seem to be part of a Th1-like inflammatory reaction in preeclampsia, most pronounced in EOP, where chemokines may be more useful than cytokines as biomarkers. Biomarkers were not correlated suggesting partly independent or in time separated mechanisms.

  • 102.
    Bonnedahl, Jonas
    et al.
    Linnaeus University, Faculty of Health and Life Sciences, Department of Biology and Environmental Science. Kalmar County Hospital.
    Jarhult, Josef D.
    Uppsala University.
    Antibiotic resistance in wild birds2014In: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 119, no 2, p. 113-116Article, review/survey (Refereed)
    Abstract [en]

    Wild birds have been postulated as sentinels, reservoirs, and potential spreaders of antibiotic resistance. Antibiotic-resistant bacteria have been isolated from a multitude of wild bird species. Several studies strongly indicate transmission of resistant bacteria from human rest products to wild birds. There is evidence suggesting that wild birds can spread resistant bacteria through migration and that resistant bacteria can be transmitted from birds to humans and vice versa. Through further studies of the spatial and temporal distribution of resistant bacteria in wild birds, we can better assess their role and thereby help to mitigate the increasing global problem of antibiotic resistance.

  • 103.
    Borcak Walder, Linda
    et al.
    Linnaeus University, Faculty of Health and Life Sciences, Department of Health and Caring Sciences.
    Grahn Holgersson, Therese
    Linnaeus University, Faculty of Health and Life Sciences, Department of Health and Caring Sciences.
    Prekonceptionell hälsa: - Vilka kunskaper och inställningar har ungdomar2018Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Background: The society should be responsible for sexual education, family planning and maternal healthcare. The midwife has a central role when it comes to spreading knowledge within the area. By spreading information  to women and men about the importance of preconception health and care it could create good conditions to start a family.  Purpose: To describe young peoples knowledge and attitudes about preconception health and care and also about what kind of knowledge the youth asks about when it comes to it. Method: A qualitative interview study with focus groups was preformed which included a group of five men ages between 21-22 and a group of  seven women who all were 18 years old. The data was analyzed by latent content analysis. Results: The knowledge the young people had about preconceptional health and care were the effects of different factors on fertility. Beneficial factors were varied health diet, exercise and good sleep. As a negative influence on fertility, tobacco, alcohol, drugs, medicines, diseases, hereditary diseases and cysts were discussed as well as stress. Knowledge the young people asked for were information on preconceptional health and care, what could influence a possible future pregnancy and facts, how the various factors affected fertility. The youth wanted the information to be obtained from someone with knowledge within the field. Conclusion: Information on preconceptional health and care was asked about by the young people, increased awareness and awareness of the subject of  public could generate positive health effects at the individual- as well as at community level with a healthier population as a result.

  • 104.
    Borg, Caroline
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Variationen i corneal kurvatur över dagen2009Independent thesis Basic level (degree of Bachelor)Student thesis
    Abstract [sv]

    För att en skarp bild ska kunna avbildas på retina krävs det att cornea och lins är transparenta men även att de innehar kvalitativa egenskaper i brytning. Fel i corneal kurvatur är en av orsakerna till refraktiva fel hos ögat. Kurvaturen kan mätas med en keratometer eller en topograf, vilken den sist nämnda även har stor betydelse bland annat vid kontaktlinstillpassning, refraktiv kirurgi och till hjälp vid diagnostisering av flera sjukdomstillstånd.

    Syfte: Syftet med den här studien var att undersöka om kurvaturen ändras under dagen, på en 8-timmars period, och i så fall hur mycket.

    Metod: Corneal kurvatur studerades på 16 ögon, 7 män och 9 kvinnor, med en median ålder på 24 år. Mätningarna utfördes med en Topcon CA-100F Corneal Analyzer, tre gånger under en dag, med fyra timmars mellanrum. Nio punkter på cornea jämfördes specifikt, vilka var apex samt 1 och 2 mm därifrån; superiort, temporalt, inferiort och nasalt.

    Resultat: Studien visade att cornea var flatast på morgonen och blev kupigare under dagen på alla mätpunkter förutom superiort. Förändringen var större på punkterna 2 mm från apex än 1 mm i alla riktningar förutom den temporala. Den totala variationen i snitt för alla punkter var en kurvaturminskning på 0,0332 ±0,07 mm och en genomsnittlig ökning i brytkraft på 0,17 ±0,35 D.

    Slutsats: Studien visar en signifikant förändring i corneal kurvatur och brytkraft under dagen. Dock var variationen i kurvatur individuell och därför ses en viktig roll i att ta topografibilder på varje enskild patient.

  • 105.
    Borghi, Claudio
    et al.
    Univ Bologna, Italy.
    Rodriguez-Artalejo, Fernando
    Univ Autonoma Madrid, Spain;Inst Salud Carlos III, Spain;IMDEA, Spain;CEI UAM CSIC, Spain.
    De Backer, Guy
    Univ Ghent, Belgium.
    Dallongeville, Jean
    Univ Lille Nord France, France.
    Medina, Jesus
    AstraZeneca, Spain.
    Nuevo, Javier
    AstraZeneca, Spain.
    Guallar, Eliseo
    Johns Hopkins Bloomberg Sch Publ Hlth, USA.
    Perk, Joep
    Linnaeus University, Faculty of Health and Life Sciences, Department of Health and Caring Sciences.
    Banegas, Jose R.
    Univ Autonoma Madrid, Spain;Inst Salud Carlos III, Spain.
    Tubach, Florence
    Hop La Pitie Salpetriere, France;INSERM, France;Sorbonne Univ, France.
    Roy, Carine
    Hop Bichat Claude Bernard, France.
    Halcox, Julian P.
    Swansea Univ, UK.
    Serum uric acid levels are associated with cardiovascular risk score: A post hoc analysis of the EURIKA study2018In: International Journal of Cardiology, ISSN 0167-5273, E-ISSN 1874-1754, Vol. 253, p. 167-173Article in journal (Refereed)
    Abstract [en]

    Background: Reports are conflicting on whether serum uric acid (sUA) levels are independently associated with increased cardiovascular (CV) death risk. Methods: This post hoc analysis assessed the relationship between sUA levels and CV death risk score in 7531 patients from the cross-sectional, multinational EURIKA study (NCT00882336). Patients had at least one CV risk factor but no clinical CV disease. Ten-year risk of CV death was estimated using SCORE-HDL and SCORE algorithms, categorized as low (<1%), intermediate (1% to <5%), high (>5% to <10%) or very high (>10%). Results: Mean serum sUA levels increased significantly with increasing CV death risk category in the overall population and in subgroups stratified by diuretics use or renal function (all P < 0.0001). Multivariate ordinal logistic regression analyses, adjusted for factors significantly associated with CV death risk in univariate analyses (study country, body mass index, number of CV risk factors and comorbidities, use of lipid lowering therapies, antihypertensives and antidiabetics), showed a significant association between sUA levels and SCORE-HDL category in the overall population (OR: 1.39 [95% CI: 1.34-1.44]) and all subgroups (using diuretics: 1.32 [1.24-1.40]; not using diuretics: 1.46 [1.39-1.53]; estimated glomerular filtration rate [eGFR] < 60 ml/min/1.73 m(2): 1.30 [1.22-1.38]; eGFR >= 60 ml/min/1.73 m(2): 1.44 [1.38-1.51]; all P < 0.0001). Similar results were obtained when using SCORE. Conclusions: Higher sUA levels are associated with progressively higher 10-year CV death risk score in patients with at least one CV risk factor but no CV disease. (c) 2017 Elsevier B.V. All rights reserved.

  • 106.
    Boström, Johanna
    et al.
    Linnaeus University, Faculty of Health and Life Sciences, Department of Medicine and Optometry.
    Pettersson, Lovisa
    ,Karolinska Institutet.
    Baskaran, Karthikeyan
    Linnaeus University, Faculty of Health and Life Sciences, Department of Medicine and Optometry.
    Källmark, Fredrik
    Källmarkskliniken, Stockholm.
    Gierow, Peter
    Linnaeus University, Faculty of Health and Life Sciences, Department of Medicine and Optometry.
    Meibography: Inter-rater reliability2016In: 8th International Conference on the Tear Film & Ocular Surface: Basic Science and Clinical Relevance: Conference Program & Abstract Book, 2016, p. 47-Conference paper (Refereed)
    Abstract [en]

    Purpose. The tear film lipid layer holds an important role in maintaining the integrity and health of the anterior surface of the eye. The meibomian glands found in eyelids are responsible for producing most of the lipids of the tear film. Dysfunction of the meibomian glands leads to increased evaporation of tears, which may lead to dry eye. Meibography is a method used for assessing the drop out of meibomian glands. The aim of this study was to evaluate the reliability between two different examiners when rating meibography images. Methods. The Sirius 3D scheimpflug camera (C.S.O., Florence, Italy) was used to photograph the everted upper and lower eyelids of the right and left eye of 52 subjects. The grade of meibomian gland loss was subjectively graded using the five-grade Meiboscale (Pult, 2012) and the percentage of gland loss was calculated using Phoenix Meibography software (version 3.0.1.021, bon Optic VertriebsGmbH, Lübeck, Germany). Data was analyzed using MedCalc for Windows (version 16.4.3, MedCalc Software, Ostend, Belgium). Results. The inter-rater reliability for the Meiboscale grade of meibomian gland loss was calculated using weighted Cohen’s kappa (linear weights). The result for all 208 images was Kw = 0.542 (95 % CI 0.454 to 0.630), which indicates a moderate agreement. The inter-rater reliability for the percentage of meibomian gland loss was calculated using intraclass correlation coefficient. The result for all 208 images was ICC = 0.794 (95 % CI 0.737 to 0.839), which indicates a substantial agreement. Conclusions. Imaging is an invaluable tool when managing patients in clinical practice. When performing meibography to evaluate meibomian gland loss, using software to calculate the percentage of gland loss gives a better inter-rater agreement than subjective grading of the images.

  • 107.
    Bremer, Anders
    University of Borås, Sweden.
    Hjärtstopp utanför sjukhus2012In: Medicinska Riksstämman, 28-30 nov 2012: Tema Framtidens hälsa, 2012Conference paper (Other academic)
  • 108.
    Bremer, Anders
    et al.
    University of Borås, Sweden.
    Axelsson, Åsa B.
    University of Gothenburg, Sweden.
    Vårdvetenskaplig analys: erfarenheter vid prehospitala hjärtstopp2016In: Prehospital akutsjukvård / [ed] Björn-Ove Suserud, Lars Lundberg, Stockholm: Liber, 2016, 2, p. 345-349Chapter in book (Other academic)
  • 109.
    Bremer, Anders
    et al.
    Linnaeus University, Faculty of Health and Life Sciences, Department of Health and Caring Sciences. Kalmar County Council, Sweden.
    Dahné, Tova
    Uppsala University, Sweden;Linköping University, Sweden.
    Stureson, Lovisa
    Linköping University, Sweden.
    Årestedt, Kristofer
    Linnaeus University, Faculty of Health and Life Sciences, Department of Health and Caring Sciences. Kalmar County Council, Sweden.
    Thylén, Ingela
    Linköping University, Sweden.
    Lived experiences of surviving in‐hospital cardiac arrest2019In: Scandinavian Journal of Caring Sciences, ISSN 0283-9318, E-ISSN 1471-6712, Vol. 33, no 1, p. 156-164Article in journal (Refereed)
    Abstract [en]

    Background

    Out‐of‐hospital cardiac arrest survivors suffer from psychological distress and cognitive impairments. They experience existential insecurity and vulnerability and are striving to return to a life in which well‐being and the meaning of life have partly changed. However, research highlighting the experiences of in‐hospital cardiac arrest survivors is lacking. This means that evidence for postresuscitation care has largely been extrapolated from studies on out‐of‐hospital cardiac arrest survivors, without considering potential group differences. Studies investigating survivors’ experiences of an in‐hospital cardiac arrest are therefore needed.

    Aim

    To illuminate meanings of people's lived experiences of surviving an in‐hospital cardiac arrest.

    Design

    An explorative, phenomenological hermeneutic method to illuminate meanings of lived experiences.

    Method

    Participants were identified through the Swedish national register of cardiopulmonary resuscitation and recruited from two hospitals. A purposive sample of eight participants, 53–99 years old, who survived an in‐hospital cardiac arrest 1–3 years earlier, was interviewed.

    Findings

    The survivors were striving to live in everyday life and striving for security. The struggle to reach a new identity meant an existence between restlessness and a peace of mind, searching for emotional well‐being and bodily abilities. The search for existential wholeness meant a quest for understanding and explanation of the fragmented cardiac arrest event and its existential consequences. The transition from hospital to home meant a transition from care and protection to uncertainty and vulnerability with feelings of abandonment, which called for a search for security and belonging, away from isolation and loneliness.

    Conclusion

    Surviving an in‐hospital cardiac arrest can be further understood by means of the concept of hospital‐to‐home transition. Following hospital discharge, patients felt vulnerable and abandoned when pending between denial and acceptance of the ‘new’ life. Hence, the healthcare system should play a significant role when it comes to facilitate cardiac arrest survivors’ security during hospital‐to‐home transition.

  • 110.
    Briland, Isabelle
    et al.
    Linnaeus University, Faculty of Health and Life Sciences, Department of Health and Caring Sciences.
    Svensson, Malinn
    Linnaeus University, Faculty of Health and Life Sciences, Department of Health and Caring Sciences.
    Ett komplext omhändertagande: - En intervjustudie om akut omhändertagande av svårt sjuka sepsispatienter och patienter med trauma2017Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Background: The population is aging and requires more complex healthcare. This means that in the future, interaction with other healthcare departments is essential. Such interaction would lead to increased demand on the ability to cooperate among healthcare personnel. The intensivecare nurse and the nurse in the emergency department have a close cooperation when managing the acute severely ill patient. A multiprofessional team gives a faster diagnosis and management in the emergency department, which shortens the time to the final instance of care. The members of the team complement each other, increasing patient safety and enabling person-centered care. Increased knowledge with the nursing staff on the acute management in emergency department is essential to be able to enhance the care for the patient in the initial stage, but focus should also be at the nurse’s experience of the acute management to identify risk factors that could pose a negative influence on the patient.Aim: The aim of this study was to describe nurses’ experience of acute management of patients with trauma and patients with severe sepsis or septic shock.Method: The method used was a qualitative, inductive approach where 14 interviews were conducted, seven with nurses from the emergency department and seven intensive care nurses from the intensive care department. The interviews were analysed using a qualitative, manifest content analysis.Result:The analyzation process resulted in five different categories: ‘Communication is A&O’, ‘The importance of knowing one’s role’, ‘Work over the borders’, ‘Working from a clear structure’ and ‘Care on different terms’. Conclusion: There is an unclear structure in the emergency care of patients with severe sepsis or septic shock, which was a result of unclear roles and inadequate communication in the care. It appears to be advantageous to introduce clear guidelines in the emergency care of the patient group with severe sepsis or septic shock, suggestively by checklists or some medical alert like a trauma alarm, and where a multi-professional team interacts around the patient.

  • 111. Broström, Anders
    et al.
    Sunnergren, Ola
    Årestedt, Kristofer
    Linnaeus University, Faculty of Health, Social Work and Behavioural Sciences, School of Health and Caring Sciences. Linköpings universitet.
    Johansson, Peter
    Ulander, Martin
    Riegel, Barbara
    Svanborg, Eva
    Factors associated with undiagnosed obstructive sleep apnoea in hypertensive primary care patients.2012In: Scandinavian Journal of Primary Health Care, ISSN 0281-3432, E-ISSN 1502-7724, Vol. 30, no 2, p. 107-113Article in journal (Refereed)
    Abstract [en]

    OBJECTIVE: In hypertensive primary care patients below 65 years of age, (i) to describe the occurrence of undiagnosed obstructive sleep apnoea (OSA), and (ii) to identify the determinants of moderate/severe OSA.

    DESIGN: Cross-sectional.

    SETTING: Four primary care health centres in Sweden.

    PATIENTS: 411 consecutive patients (52% women), mean age 57.9 years (SD 5.9 years), with diagnosed and treated hypertension (BP >140/90).

    MAIN OUTCOME MEASURES: Occurrence of OSA as measured by the apnoea hypopnoea index (AHI).

    RESULTS: Mild (AHI 5-14.9/h) and moderate/severe (AHI > 15/h) OSA were seen among 29% and 30% of the patients, respectively. Comparing those without OSA with those with mild or moderate/severe OSA, no differences were found in blood pressure, pharmacological treatment (anti-hypertensive, anti-depressive, and hypnotics), sleep, insomnia symptoms, daytime sleepiness, or depressive symptoms. Obesity (BMI > 30 kg/m2) was seen in 30% and 68% of the patients with mild and moderate/severe OSA, respectively. Male gender, BMI > 30 kg/m2, snoring, witnessed apnoeas, and sleep duration >8 hours were determinants of obstructive sleep apnoea.

    CONCLUSION: Previously undiagnosed OSA is common among patients with hypertension in primary care. Obesity, snoring, witnessed apnoeas, long sleep duration, and male gender were the best predictors of OSA, even in the absence of daytime sleepiness and depressive symptoms.

  • 112.
    Brunt, David
    Linnaeus University, Faculty of Health and Life Sciences, Department of Health and Caring Sciences.
    Boende2014In: Att leva med psykisk funktionsnedsättning: livssituation och effektiva vård- och stödinsats / [ed] David Brunt och Lars Hansson, Lund: Studentlitteratur AB, 2014, 2, p. 99-116Chapter in book (Other academic)
  • 113.
    Brunt, David
    Linnaeus University, Faculty of Health and Life Sciences, Department of Health and Caring Sciences.
    Socialt nätverk2014In: Att leva med psykisk funktionsnedsättning: livssituation och effektiva vård- och stödinsatser / [ed] David Brunt och Lars Hansson, Lund: Studentlitteratur AB, 2014, 2, p. 171-188Chapter in book (Other academic)
  • 114.
    Brunt, David
    et al.
    Linnaeus University, Faculty of Health and Life Sciences, Department of Health and Caring Sciences. Centre for Evidence-based Psychosocial Interventions for people with severe mental illness CEPI, Sweden.
    Hansson, Lars
    Lund University, Sweden ; Centre for Evidence-based Psychosocial Interventions for people with severe mental illness CEPI, Sweden.
    Att leva med psykisk funktionsnedsättning: livssituation och effektiva vård- och stödinsatser2014 (ed. 2)Book (Other academic)
    Abstract [sv]

    Den psykiatriska vården och det offentliga stödsystemet för personer med psykisk funktionsnedsättning är i dag huvudsakligen ett samhälls­baserat servicesystem med tyngdpunkt i öppna vårdformer. Det finns emellertid uppenbara brister i systemets förmåga att möta vård- och stödbehovet hos dessa personer,liksom det finns övergripande brister i deras livssituation i samhället som helhet. Trots omfattande reformer kännetecknas fortfarande situationen för personer med psykiska funktionshinder i många avseenden av diskriminering och andra former av stigmatisering samt ekonomisk, social och politisk marginalisering och maktlöshet. Upplevelser av bristande medinflytande och kontroll över den egna vård- och stödsituationen påverkar dem också negativt.

    Trots svårigheter att implementera evidensbaserade och effektiva insatser samt starka vetenskapliga belägg för att de reformer som genomdrivits i syfte att förbättra livssituationen i många avseenden inte har nått målen, finns det ändå anledning till optimism. Det här är den andra reviderade upplagan av boken, och här redovisas rehabiliteringsinsatser och andra interventioner som visar att det finns effektiva sätt att förändra situationen.

    Att leva med psykisk funktionsnedsättning vänder sig till studerande inom sociala eller vårdinriktade högskoleutbildningar,men också till personer inom vård- och stödverksamheter som i arbetet möter personer med psykiska funktionsnedsättningar.

  • 115.
    Brunt, David
    et al.
    Linnaeus University, Faculty of Health and Life Sciences, Department of Health and Caring Sciences.
    Rask, Mikael
    Linnaeus University, Faculty of Health and Life Sciences, Department of Health and Caring Sciences.
    Validation of the Verbal and Social Interaction questionnaire: carers' focus in the carer–resident relationship in supported housing facilities for persons with psychiatric disabilities (VSI-SH)2013In: Journal of Psychiatric and Mental Health Nursing, ISSN 1351-0126, E-ISSN 1365-2850, Vol. 20, no 3, p. 279-285Article in journal (Refereed)
    Abstract [en]

    A questionnaire to measure the verbal and social interactions between carers and residents in supported housing facilities for persons with psychiatric disabilities has been developed. It is an adaptation of a questionnaire originally used in a forensic psychiatric setting. The aim of the present study was thus to investigate the construct validity and the reliability of this new version of the Verbal and Social Interactions questionnaire for use in supported housing facilities (VSI-SH). Two hundred and twenty-three carers from municipal and privately run housing facilities completed the questionnaire. A factor analysis was performed, which resulted in six factors. The number of items was reduced from the original 47 to 30 in order to minimize factorial complexity and multiple loadings. The reliability was tested with Cronbach's alpha and good internal consistency for the questionnaire and five of the six factors was found. The resulting six factors and the items were compared to the conceptual model and four of the six factors corresponded well with the categories in this original theoretical model. The questionnaire can be a useful contribution to the study of interactions between carers and residents in supported housing facilities for persons with psychiatric disabilities.

  • 116.
    Brunt, David
    et al.
    Växjö University, Faculty of Humanities and Social Sciences, School of Health Sciences and Social Work.
    Rask, Mikael
    Växjö University, Faculty of Humanities and Social Sciences, School of Health Sciences and Social Work.
    Ward Atmosphere – the Scarlet Pimpernel of psychiatric settings?2007In: Issues in Mental Health Nursing, Vol. 28, no 6, p. 639-656Article in journal (Refereed)
    Abstract [en]

    Patients and staff in a forensic psychiatric setting were requested to name three distinguishing characteristics of the ward atmosphere. The manifest content analysis of the responses revealed the following categories: interpersonal relations and pre-conditions for interpersonal relations, organization, staff, treatment, daily activities, physical environment and feeling good and secure. The patients appeared to have a peripheral role as contributors to the ward atmosphere in the views of the respondents. The easily administered single question format provided valuable information about that intangible element of psychiatric settings – the ward atmosphere.

  • 117.
    Brålander, Zara
    et al.
    University of Kalmar, School of Human Sciences.
    Svensson, Åsa
    University of Kalmar, School of Human Sciences.
    Faktorer som främjar respektive hindrar en god interaktion mellan vårdpersonal och personer med demens.: En systematisk litteraturstudie.2009Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Sammanfattning

     

    Bakgrund: Demenssjukdomar är vanligt förekommande hos äldre, vid 90 års ålder är cirka 50 procent drabbade av demenssjukdomar. Demenssjukdomar leder till beteende- och kommunikations svårigheter, vilket kan försvåra omvårdnadsarbetet och interaktionen mellan vårdpersonal och personer med demens. Syfte: Belysa faktorer som främjar respektive hindrar en god interaktion mellan vårdpersonal och personer med demens. Metod: En systematisk litteraturstudie baserad på tio vetenskapliga artiklar. Resultat: Omvårdnaden av personer med demens påverkas av interaktionen mellan dem och vårdpersonalen. Interaktionen i sin tur påverkas av olika främjande respektive hindrande faktorer. En central faktor var kommunikationens betydelse hos både vårdpersonal och personer med demens. Det framkom att både vårdpersonal och personer med demens kan påverka interaktionen, men det är vårdpersonalen som har det största ansvaret. Slutsats: Med en ökad kunskap om hur främjande respektive hindrande faktorer hos vårdpersonal och hos personer med demens påverkar interaktionen ökar möjligheten att tillgodose patienternas behov och samtidigt få dem att känna sig unika och värdefulla.

  • 118.
    Buetti-Dinh, Antoine
    et al.
    Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences. Università della Svizzera Italiana, Italy;Swiss Institute of Bioinformatics, Switzerland.
    Friedman, Ran
    Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences.
    Computer simulations of the signalling network in FLT3+-acute myeloid leukaemia: indications for an optimal dosage of inhibitors against FLT3 and CDK62018In: BMC Bioinformatics, ISSN 1471-2105, E-ISSN 1471-2105, Vol. 19, p. 1-13, article id 155Article in journal (Refereed)
    Abstract [en]

    Background

    Mutations in the FMS-like tyrosine kinase 3 (FLT3) are associated with uncontrolled cellular functions that contribute to the development of acute myeloid leukaemia (AML). We performed computer simulations of the FLT3-dependent signalling network in order to study the pathways that are involved in AML development and resistance to targeted therapies.

    Results

    Analysis of the simulations revealed the presence of alternative pathways through phosphoinositide 3 kinase (PI3K) and SH2-containing sequence proteins (SHC), that could overcome inhibition of FLT3. Inhibition of cyclin dependent kinase 6 (CDK6), a related molecular target, was also tested in the simulation but was not found to yield sufficient benefits alone.

    Conclusions

    The PI3K pathway provided a basis for resistance to treatments. Alternative signalling pathways could not, however, restore cancer growth signals (proliferation and loss of apoptosis) to the same levels as prior to treatment, which may explain why FLT3 resistance mutations are the most common resistance mechanism. Finally, sensitivity analysis suggested the existence of optimal doses of FLT3 and CDK6 inhibitors in terms of efficacy and toxicity.

  • 119.
    Buetti-Dinh, Antoine
    et al.
    Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences. Univ Svizzera Italiana, Switzerland;Swiss Inst Bioinformat, Switzerland.
    Jensen, Rebecca
    Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences. Univ Svizzera Italiana, Switzerland;Swiss Inst Bioinformat, Switzerland.
    Friedman, Ran
    Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences.
    A computational study of hedgehog signalling involved in basal cell carcinoma reveals the potential and limitation of combination therapy2018In: BMC Cancer, ISSN 1471-2407, E-ISSN 1471-2407, Vol. 18, no 1, p. 1-8, article id 569Article in journal (Refereed)
    Abstract [en]

    Background: The smoothened (SMO) receptor is an essential component of the Sonic hedgehog (SHH) signalling, which is associated with the development of skin basal cell carcinoma (BCC). SMO inhibitors are indicated for BCC patients when surgical treatment or radiation therapy are not possible. Unfortunately, SMO inhibitors are not always well tolerated due to severe side effects, and their therapeutical success is limited by resistance mutations. Methods: We investigated how common are resistance-causing mutations in two genomic databases which are not linked to BCC or other cancers, namely 1000 Genomes and ExAC. To examine the potential for combination therapy or other treatments, we further performed knowledge-based simulations of SHH signalling, in the presence or absence of SMO and PI3K/Akt inhibitors. Results: The database analysis revealed that of 18 known mutations associated with Vismodegib-resistance, three were identified in the databases. Treatment of individuals carrying such mutations is thus liable to fail a priori. Analysis of the simulations suggested that a combined inhibition of SMO and the PI3K/Akt signalling pathway may provide an effective reduction in tumour proliferation. However, the inhibition dosage of SMO and PI3K/Akt depended on the activity of phosphodiesterases (PDEs). Under high PDEs activities, SMO became the most important control node of the network. By applying PDEs inhibition, the control potential of SMO decreased and P13K appeared as a significant factor in controlling tumour proliferation. Conclusions: Our systems biology approach employs knowledge-based computer simulations to help interpret the large amount of data available in public databases, and provides application-oriented solutions for improved cancer resistance treatments.

  • 120.
    Buetti-Dinh, Antoine
    et al.
    Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences. Univ Svizzera Italiana, Switzerland;Swiss Inst Bioinformat, Switzerland.
    O'Hare, Thomas
    Univ Utah, USA;Huntsman Canc Inst, USA.
    Friedman, Ran
    Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences.
    Sensitivity Analysis of the NPM-ALK Signalling Network Reveals Important Pathways for Anaplastic Large Cell Lymphoma Combination Therapy2016In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 11, no 9, article id e0163011Article in journal (Refereed)
    Abstract [en]

    A large subset of anaplastic large cell lymphoma (ALCL) patients harbour a somatic aberration in which anaplastic lymphoma kinase (ALK) is fused to nucleophosmin (NPM) resulting in a constitutively active signalling fusion protein, NPM-ALK. We computationally simulated the signalling network which mediates pathological cell survival and proliferation through NPM-ALK to identify therapeutically targetable nodes through which it may be possible to regain control of the tumourigenic process. The simulations reveal the predominant role of the VAV1-CDC42 (cell division control protein 42) pathway in NPM-ALK-driven cellular proliferation and of the Ras / mitogen-activated ERK kinase (MEK) / extracellular signal-regulated kinase (ERK) cascade in controlling cell survival. Our results also highlight the importance of a group of interleukins together with the Janus kinase 3 (JAK3) / signal transducer and activator of transcription 3 (STAT3) signalling in the development of NPM-ALK derived ALCL. Depending on the activity of JAK3 and STAT3, the system may also be sensitive to activation of protein tyrosine phosphatase-1 (SHP1), which has an inhibitory effect on cell survival and proliferation. The identification of signalling pathways active in tumourigenic processes is of fundamental importance for effective therapies. The prediction of alternative pathways that circumvent classical therapeutic targets opens the way to preventive approaches for countering the emergence of cancer resistance.

  • 121.
    Buono, Nicola
    et al.
    National Society of Medical Education in General Practice (SNAMID), Italy.
    Thulesius, Hans
    Region Kronoberg, Sweden.
    Petrazzuoli, Ferdinando
    National Society of Medical Education in General Practice (SNAMID), Italy;Lund university.
    Castelli, Elena
    National Society of Medical Education in General Practice (SNAMID), Italy.
    Cambielli, Marco
    National Society of Medical Education in General Practice (SNAMID), Italy.
    Postherpetic neuralgia, diabetic neuropathy, and trigeminal neuralgia - Chronic peripheral neuropathic pain in 58,480 rural Italian primary care patients2017In: Journal of family medicine and primary care, ISSN 2249-4863, Vol. 6, no 1, p. 110-114Article in journal (Refereed)
    Abstract [en]

    INTRODUCTION: Chronic peripheral neuropathic pain (CPNP) is a condition due to peripheral nervous system diseases or injury, but its prevalence is unknown in Italian primary care.

    AIM: The aim of this study is to assess the prevalence of CPNP in a rural primary care area in Northern Italy.

    MATERIALS AND METHODS: A multicenter audit study was carried out in a rural area in Northern Italy with 113 participating general practitioners (GPs) seeing 58,480 patients >18 years during 3 months. Patients who for any reason attended GPs' surgeries and had symptoms suggestive of neuropathic pain (NP) were given the NP diagnostic questionnaire "Douleur Neuropathique en 4 Questions" (DN4) and recorded their pain level on a visual analog scale (VAS).

    RESULTS: Chronic NP was established by a DN4 score of ≥4 and a VAS pain score of ≥40 mm for >6 months together with a clinical diagnosis in 448 (254 women and 194 men) out of 58,480 patients giving a prevalence of 0.77%. 179 patients (0.31%) had diabetes neuropathy, 142 (0.24%) had postherpetic pain, 41 (0.07%) had trigeminal neuralgia, 27 (0.05%) had NP postinjury, 27 (0.05%) had NP caused by nerve entrapments, 11 (0.02%) had NP triggered by systemic diseases, and 21 (0.04%) had NP of unknown etiology.

    CONCLUSIONS: The prevalence of CPNP in this population of primary care attenders in a rural area in Northern Italy was 0.77%. Diabetes neuropathy (0.31%) and postherpetic pain (0.24%) were the two most common subgroups of NP, followed by trigeminal neuralgia (0.07%).

  • 122. Burell, G
    et al.
    Carlsson, R
    Hambraeus, K
    Johansson, P
    Lisspers, J
    Perk, Joep
    Linnaeus University, Faculty of Health, Social Work and Behavioural Sciences, School of Health and Caring Sciences.
    Efter perkutan koronar intervention (PCI): en enkät bland 1073 patienter2012In: XIV Svenska Kardiovaskulära Vårmötet, 2012Conference paper (Refereed)
  • 123.
    Byrlind Cronqvist, Olle
    et al.
    Linnaeus University, Faculty of Health and Life Sciences, Department of Health and Caring Sciences.
    Ryd, Sofie
    Linnaeus University, Faculty of Health and Life Sciences, Department of Health and Caring Sciences.
    Intensivvårdssjuksköterskors och anestesiologers erfarenheter av intensivvårdsrelaterad posttraumatiskt stressyndrom hos intensivvårdspatienter: En intervjustudie2019Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Bakgrund: Posttraumatiskt stressyndrom (PTSD) är ett tillstånd som kännetecknas av ångest och oro relaterat till situationer som påminner om en traumatisk händelse. Intensivvårdsrelaterad PTSD har fått ökad uppmärksamhet de senaste åren. Genom ett preventivt arbete och tidiga insatser minskar risken för att patienter utvecklar PTSD. För att detta ska ske krävs god kunskap av problemet hos intensivvårdspersonal. Hur deras erfarenheter ser ut är tidigare outforskat.

    Syfte: Syftet var att beskriva intensivvårdssjuksköterskors och anestesiologers erfarenheter av intensivvårdsrelaterad PTSD hos intensivvårdspatienter.

    Metod: En kvalitativ intervjustudie gjordes. Semistrukturerade och individuella intervjuer genomfördes med nio intensivvårdssjuksköterskor och fyra anestesiologer. Data analyserades med en kvalitativ innehållsanalys.

    Resultat: Analysen resulterade i tre kategorier: En känsla att vi kan göra mer, Att normalisera livet och Fortsatt stöd efter tiden på IVA. Resultatet visade att delirium upplevdes vara en ledande riskfaktor till PTSD. Relationer och kommunikation upplevdes som viktiga i det profylaktiska arbetet mot PTSD. Post-IVAmottagningar och dagböcker tros kunna bidra till bättre uppföljning och kan fungera preventivt mot PTSD.

    Slutsats: Resultatet visar att det finns en liten erfarenhet om PTSD efter intensivvård, ändå förekom ett omedvetet preventivt arbete. En organisatorisk satsning behövs för att öka medvetenhet hos intensivvårdspersonalen. Det behövs mer kvalitativ och kvantitativ forskning om bland annat riskfaktorer och uppföljning gällande intensivvårdsrelaterad PTSD.

  • 124.
    Byrmo, Linda
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Effect of soft contact lens power on intraocular pressure measurement.2009Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 125.
    Cabalgante, Sandra
    et al.
    Linnaeus University, Faculty of Health, Social Work and Behavioural Sciences, School of Health and Caring Sciences.
    Zapata Pon, Milagros
    Linnaeus University, Faculty of Health, Social Work and Behavioural Sciences, School of Health and Caring Sciences.
    Hur sexuella övergreppsupplevelser i barndomen påverkar den vuxna människans möte med vården2010Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 126.
    Carlsson, Jörg
    et al.
    Kalmar County Hospital.
    Danielsson, Tom
    Linnaeus University, Faculty of Social Sciences, Department of Sport Science.
    Bergman, Patrick
    Linnaeus University, Faculty of Social Sciences, Department of Sport Science.
    A two-peaked increase of serum myosin heavy chain-α after full distance triathlon demonstrates heart muscle cell death2017In: Clinical Research in Cardiology, ISSN 1861-0684, E-ISSN 1861-0692, Vol. 106, no Suppl 1, article id P1159Article in journal (Refereed)
    Abstract [en]

    Background: There is an ongoing debate about the significance of cardiac troponin T (cTnT) elevation after strenuous exercise: heart muscle cell death versus physiologic mechanism of release through an intact cell membrane. While cTnT is a small molecule (37 kDa), cardiac specific myosin heavy chain-alpha (MHC-α) is much larger (224 kDa) and an increase after exercise could hardly be explained by passage through an intact cardiac cell membrane. PURPOSE: To measure MHC-α, and other biomarkers (C-reactive protein (CRP); cTnT, creatine kinase (CK), myoglobin (MG), creatinine (C), and N-terminal prohormone of brain natriuretic peptide (NT-proBNP) before and after a full distance Ironman in order to answer the question of heart muscle cell death versus physiologic changes. 

    Methods: In 52 non-elite athletes (14 female, 38 male; age 41.1 ± 9.7, range 24-70 years; all completed the race) biomarkers were measured by standard laboratory methods 7 days before, directly after, and day 1, 4 and 6 after the race. MHC-α was measured with a commercially available ELISA with no cross reactivity with other myosins. 

    Results: The course of MHC-α concentration [µg/L] was 1.33 ± 0.53 (before), 2.57 ± 0.78 (directly after), 1.51 ± 0.53 (day 1), 2.74 ± 0.55 (day 4) and 1.83 ± 0.76 (day 6). Other biomarkers showed a one-peaked increase with maximal values either directly after the race or at day 1: cTnT 76 ± 80 ng/L (12-440; reference <15), NT-proBNP 776 ± 684 ng/L (92-4700; ref. < 300), CK 68 ± 55 µkat/L (5-280; ref. < 1.9), MG 2088 ± 2350 µg/L (130-17000; ref.< 72), and creatinine 100 ± 20 µmol/L (74-161; ref. < 100), CRP 49 ± 23 mg/L (15-119; ref.< 5). There was a significant correlation between MHC-α and NT-proBNP (R=0.48; p<0.001) but neither between MHC-α and cTnT (R=0.13; p=0.36) nor MHC-α and myoglobin (R=0.18; p=0.2). 

    Conclusion: An Ironman leads to remarkable disturbances in biomarkers as e.g. cTnT was in the range of myocardial infarction in 100% of women and 97% of men. This is to our best knowledge the first investigation of MHC-α after strenuous exercise and its two-peaked increase most likely represents first release from the cytosolic pool and later from cell necrosis including the contractile apparatus. However, many questions remain, not at least why MHC-α baseline levels are as high as 1.33 ± 0.53 µg/L. 

  • 127.
    Carlsson, Jörg
    et al.
    Kalmar County Hospital.
    Danielsson, Tom
    Linnaeus University, Faculty of Social Sciences, Department of Sport Science.
    Bergman, Patrick
    Linnaeus University, Faculty of Social Sciences, Department of Sport Science.
    Two-peaked increase of serum myosin heavy chain-α after Ironman demonstrates heart muscle cell death2017In: Medicine & Science in Sports & Exercise, ISSN 0195-9131, E-ISSN 1530-0315, Vol. 47, no 5 Supplement 1, p. 186-, article id 734Article in journal (Other academic)
  • 128.
    Carlsson, Jörg
    et al.
    Linnaeus University, Faculty of Health and Life Sciences, Department of Health and Caring Sciences.
    Danielsson, Tom
    Linnaeus University, Faculty of Social Sciences, Department of Sport Science.
    Bergman, Patrick
    Linnaeus University, Faculty of Social Sciences, Department of Sport Science.
    Schreyer, Hendrik
    Kalmar County Hospital.
    Echocardiographic Findings and Cardiac Biomarkers in Non-Elite Triathletes – Data from the Kalmar Ironwoman Study2018Conference paper (Refereed)
    Abstract [en]

    INTRODUCTION: There is an ongoing debate about the impact of endurance exercise on cardiovascular health. Not at least data on cardiac biomarker changes (e.g. troponin T (cTnT), N-terminal prohormone of brain natriuretic peptide (NT-proBNP) and cardiac specific myosin heavy chain-alpha (MHC-α) have raised questions about exercise related cardiac injury. METHODS: In 52 non-elite athletes (14 female, 38 male; age 41.1 ± 9.7, range 24-70 years; all completed the race) biomarkers were measured by standard laboratory methods 7 days before, directly after, and day 1, 4 and 6 after a full Ironman distance triathlon (Swim 3.9 km, Bike 180 km, Run 42.2 km) . In 19 of these athletes (9 female, 10 male) echocardiography with 30 different standard measurements was performed before and directly after the race. RESULTS: Only MHC-α [µg/L] showed a two-peaked increase directly after (2.57 ± 0.78) and on day 4 (2.74 ± 0.55). Other biomarkers showed a one-peaked increase with maximal values either directly after the race or at day 1: cTnT 76 ± 80 ng/L (12-440; reference <15), NT-proBNP 776 ± 684 ng/L (92-4700; ref. < 300), CK 68 ± 55 µkat/L (5-280; ref. < 1.9), MG 2088 ± 2350 µg/L (130-17000; ref.< 72), and creatinine 100 ± 20 µmol/L (74-161; ref. < 100), CRP 49 ± 23 mg/L (15-119; ref.< 5). No significant echocardiographic changes were recorded. E.g. left ventricular end diastolic diameter (49.0 ± 4.7 mm before, 47.7 ± 5.0 mm after the race, right ventricular end diastolic diameter (34.3 ± 4.3 mm before, 33.3 ± 5.7 mm after the race), right atrial area (17.5 ± 2.9 cm2 before, 17.7 ± 3.6 cm2 after the race) and left atrial area (18.8 ± 3.7 cm2 before, 17.8 ± 2.2 cm2 after the race) did not show any significant acute changes. CONCLUSION: While an Ironman leads to remarkable disturbances in biomarkers as e.g. cTnT after the race was in the range of myocardial infarction in 100% of women and 97% of men, these alterations were not correlated to any acute echocardiographic changes in heart size or function. However, the significance of biochemical evidence of cardiac injury on long-term heart function and cardiovascular health remains unclear.

  • 129.
    Carlsson, Jörg
    et al.
    Linnaeus University, Faculty of Health and Life Sciences, Department of Health and Caring Sciences.
    Ragnarsson, Thony
    Linnaeus University, Faculty of Social Sciences, Department of Sport Science.
    Danielsson, Tom
    Linnaeus University, Faculty of Social Sciences, Department of Sport Science.
    Bergman, Patrick
    Linnaeus University, Faculty of Social Sciences, Department of Sport Science.
    Increase of biomarkers after the Kalmar Ironman in male and female non-elite triathletes2016Conference paper (Refereed)
    Abstract [en]

    Strenuous and prolonged exercise like marathon, ultra running and triathlon can lead to changes in biomarkers of cardiac, muscle and kidney functional damage.

    We present the data of 29 (15 male, 14 female) non-elite participants of the Kalmar Ironman 2015 3.8 km swimming, 180 km cycling, 42 km running). Pre-race electrocardiograms and echocardiograms showed a high frequency of abnormalities. Post race elevations of troponin T, creatine kinase, myoglobin, N-terminal pro b-type natriuretic peptide, aspartataminotransferas, creatinine and leucocytes returned to normal in almost all cases within 5-8 days. In 100% of male and 93% of female participants’ troponin T increase was compatible with the diagnosis of minor myocardial infarction. Some results are shown in the table (* denotes level of significance between male and female results).

                                               Before race         Directly after race        5-8 days after race

    CK [µkat/L]                                      

    male                                                 3.7 ± 2.1**       48,1 ± 44.1                4.5 ± 4.0

    female                                   1.5 ± 0.7          30.5 ± 41.5                3.1 ± 3.6

    Myoglobin [µg/L

    male                                      58.3 ± 35.9        2449 ± 1923             51.3 ± 38.5

    female                                    30.6 ± 11.0         1134 ± 756*             50.4 ± 67.7

    Creatinine [µmol/L]

    male                                       87.4 ± 11.4         119.9 ± 23.4           85.1 ± 12.1

    female                                     73.0 ± 13.4         84.1 ± 14.1***        69.6 ± 6.3

    p-NT-proBNP [ng/L]

    male                                        60.1 ± 25.2          658.7 ± 354.9        61.9 ± 22.7

    female                                      95.5 ± 69.5          907.9 ± 433.1        76.9 ± 26.9

    Troponin T [ng/L]

    male                                         8.5 ± 4.3             68.1 ± 41.1           7.4 ± 4.4

    female                                       7.1 ± 4.9             54.3 ± 49.5           5.8 ± 1.7

    The results will be discussed in the light of the current literature and the so far unanswered question about the long-term significance of repetitive organ damage due to strenuous exercise. Long-term follow-up of these athletes is needed.

  • 130.
    Carlsson, Jörg
    et al.
    Linnaeus University, Faculty of Health and Life Sciences, Department of Health and Caring Sciences. Kalmar County Hospital, Sweden;Justus-Liebig Universität Giessen, Germany.
    Ragnarsson, Thony
    Linnaeus University, Faculty of Social Sciences, Department of Sport Science.
    Danielsson, Tom
    Linnaeus University, Faculty of Social Sciences, Department of Sport Science.
    Johansson, Therése
    Kalmar County Hospital, Sweden.
    Schreyer, Hendrik
    Kalmar County Hospital, Sweden.
    Breyne, Antonia
    Justus-Liebig Universität Giessen, Germany.
    Bergman, Patrick
    Linnaeus University, Faculty of Social Sciences, Department of Sport Science.
    Hjärtmarkörer ökar efter intensiv motion - oklar klinisk betydelse: Data från förstudie av Kalmar IronWoman-studien visar på troponin T-värden som vid hjärtinfarkt2016In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 113, no 31-33, article id D3CRArticle in journal (Refereed)
    Abstract [en]

    Biochemical changes after strenuous exercise - data from the Kalmar Ironman

    Strenuous and prolonged exercise like marathon, ultra running and triathlon can lead to changes in biomarkers of cardiac, muscle and kidney functional damage. We present the data of 30 (15 men, 15 women) participants of the Kalmar Ironman 2015. Pre-race electrocardiograms and echocardiograms showed a high frequency of abnormalities. Post race elevations of troponin T, creatine kinase, myoglobin, N-terminal prohormone of brain natriuretic peptide, and creatinine returned to normal in almost all cases within 5-8 days. In all but one participant the troponin T pattern was compatible with the diagnosis of myocardial infarction. It is an up-to-date unanswered question whether the increase of troponin represents myocardial damage or just is a benign consequence of an intermittent change of the permeability of myocardial cell membranes.

  • 131.
    Carlsson, Kristina
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Den Perifera Synskärpan med Normal och Omvänd Polaritet2008Independent thesis Basic level (degree of Bachelor)Student thesis
    Abstract [sv]

    Bakgrund: Vid förlust av den centrala synskärpan måste personer använda sig av den perifera delen av näthinnan, så kallad excentrisk fixation. Personen måste medvetet fokusera vid sidan av objektet så att bilden faller in på deras BNP, bästa näthinneplatsen. Användningen av den perifera delen av näthinnan innebär en försämrad synskärpa. Försämringen beror på att fotoreceptorerna är färre och placerade längre ifrån varandra. De aberrationer som uppkommer vid excentrisk fixation såsom sned astigmatism, koma, defokus och högre gradens aberrationer inverkar också på synskärpan. För att få den bästa möjliga perifera synskärpa har det visat sig att synsvaga personer föredrar att använda sig av omvänd polaritet, det vill säga vita bokstäver på svart bakgrund, om det finns möjlighet att välja.

    Syfte: Syftet med detta arbete var att undersöka om det var någon skillnad i den perifera synskärpan mellan normal och omvänd polaritet med optotypen Landolt C.

    Metod: Studien gjordes på 30 testdeltagares friska vänsterögon i en vinkel på 20 grader från makula. För att bestämma den perifera synskärpan för de båda polariteterna användes metoden: perifer visuell evaluering, PVE.

    Resultat: Resultatet visade att majoriteten av deltagarna uppnådde bäst visus vid normal polaritet. De stora standardavvikelserna hos försökspersonerna gör dock att resultatet inte är statisktiskt signifikant.

    2008:O4

  • 132.
    Carlsson, Martin
    et al.
    Linnaeus University, Faculty of Health and Life Sciences, Department of Medicine and Optometry. Kalmar County Hospital.
    Brudin, Lars
    Kalmar County Hospital;Univ Hosp Linköping.
    Wanby, Pär
    Kalmar County Hospital.
    Directly measured free 25-hydroxy vitamin D levels show no evidence of vitamin D deficiency in young Swedish women with anorexia nervosa2018In: Eating and Weight Disorders, ISSN 1124-4909, E-ISSN 1590-1262, Vol. 23, no 2, p. 247-254Article in journal (Refereed)
    Abstract [en]

    Purpose Anorexia nervosa (AN) is an eating disorder characterized by low fat mass complicated by osteoporosis. The role of circulating vitamin D in the development of bone loss in AN is unclear. Fat mass is known to be inversely associated with vitamin D levels measured as serum levels of total, protein-bound 25-hydroxyvitamin D, but the importance of directly measured, free levels of 25(OH)D has not been determined in AN. The aim of this study was to investigate vitamin D status, as assessed by serum concentrations of total and free serum 25(OH)D in patients with AN and healthy controls. Methods In female AN patients (n = 20), and healthy female controls (n = 78), total 25(OH)D was measured by LC-MS/MS, and free 25(OH)D with ELISA. In patients with AN bone mineral density (BMD) was determined with DEXA. Results There were no differences between patients and controls in total or free S-25(OH)D levels (80 +/- 31 vs 72 +/- 18 nmol/L, and 6.5 +/- 2.5 vs 5.6 +/- 1.8 pg/ml, respectively), and no association to BMD was found. In the entire group of patients and controls, both vitamin D parameters correlated with BMI, leptin, and PTH. Conclusions The current study did not demonstrate a vitamin D deficiency in patients with AN and our data does not support vitamin D deficiency as a contributing factor to bone loss in AN. Instead, we observed a trend toward higher vitamin D levels in AN subjects compared to controls. Measurement of free vitamin D levels did not contribute to additional information.

  • 133.
    Carlsson, Martin
    et al.
    Linnaeus University, Faculty of Health and Life Sciences, Department of Medicine and Optometry. Kalmar County Hospital.
    Nilsson, Ingela
    Kalmar County Hospital.
    Brudin, Lars
    Kalmar County Hospital ; Linköping University Hospital.
    Von, Siv-Ping
    Kalmar County Hospital.
    Wanby, Pär
    Kalmar County Hospital.
    Erythrocyte fatty acid composition does not influence levels of free, bioavailable, and total 25-hydroxy vitamin D2017In: Scandinavian Journal of Clinical and Laboratory Investigation, ISSN 0036-5513, E-ISSN 1502-7686, Vol. 77, no 1, p. 45-52Article in journal (Refereed)
    Abstract [en]

    In vitro, mono- and polyunsaturated fatty acids (FAs) may decrease the binding affinity of vitamin D metabolites for vitamin D-binding protein, which in turn may influence their bioavailability. FAs incorporated as phospholipids in erythrocyte (ery-) cell membranes reflect dietary intake. The purpose of this study was to investigate ery-FA composition in relation to markers for vitamin D. In healthy females (age 22.6 +/- 2.0 years) total 25(OH)D was measured by LC-MS/MS (n=78), free 25(OH)D with ELISA (n=64 of 78), and bioavailable 25(OH)D was calculated. Analysis of ery-FA composition was by gas chromatography (n=56 of 78). A strong correlation between total 25(OH)D and free 25(OH)D was seen (r=.66, p<.001), and between total-25(OH)D and bioavailable 25(OH)D (r=.68, p<.001). No correlations between 25(OH)D fractions and specific fatty acids were found, and in particular, no associations with mono- and poly-unsaturated FA compositions. All 25(OH)D fractions were correlated with leptin (total 25(OH)D (r=-.33, p<.003); bioavailable 25(OH)D (r=-.47, p<.001); free 25(OH)D (r=-.44, p<.001). Associations were found between PTH and total 25(OH)D (r=-.35, p=.002) and weaker between bioavailable 25(OH)D (r=-.35, p=.040) and free 25(OH)D (r=-.28, p=.079). All fractions of 25(OH)D appear to correlate in a similar way to PTH, BMI and body fat (leptin). No association was found between ery-FA composition and free/bioavailable 25(OH)D. It is unlikely that FAs are a strong uncoupling factor of DBP-bound 25(OH)D.

  • 134.
    Carlsson, Mats
    Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences.
    Hur korrigering av excentriska synfel påverkar perifer visus2011Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 135.
    Carlsson, Stina K.
    Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences.
    Effects of adenosine and acetylcholine on the lacrimal gland2011Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    A balanced tear film is essential for a healthy ocular surface. Insufficient tear production may result in dry eye, a common disorder in the elderly population. Dry eye causes significant discomfort in the patients and may lead to visual impairment and ocular infections. The lacrimal gland secretes water, proteins and electrolytes to the aqueous layer of the tear film. Lacrimal gland secretion is tightly regulated by e.g. neuronally released acetylcholine. The effect of acetylcholine on lacrimal gland secretion was recently found to be potentiated by adenosine. Adenosine is an important signaling molecule acting upon the adenosine receptors: A1, A2A, A2B and A3.

    The aim of this thesis was to study effects of adenosine and acetylcholine on intracellular signaling pathways and lacrimal gland secretion. Cholinergic stimulation of secretion was shown to be regulated by the mitogen activated protein kinase p38, a protein previously not known to be involved in exocrine secretion. p38 was activated in response to cholinergic stimulation and inhibition of p38 significantly diminished cholinergic secretion.

    When investigating adenosine effects, potentiation of cholinergic secretion was observed by activation of the A2B receptor in addition to the previously studied A1 receptor. An A2 receptor agonist increased cholinergic rabbit lacrimal gland protein secretion at several concentrations. The increase was inhibited by antagonism of the A2B receptor, but not the A2A receptor. When investigating the intracellular signaling pathways following adenosine and acetylcholine receptor activation, adenosine was shown to increase of cAMP levels. An additional increase in cAMP levels was observed after parallel adenosine and cholinergic receptor activation. Inhibition of Ca2+ release from the endoplasmic reticulum had inhibitory effects of cholinergic stimulation of secretion. In addition, the expression of adenosine receptors in a mouse model of autoimmune dry eye was investigated. The results showed a lymphocyte dependent upregulation of A2A receptors in diseased mice compared to controls.

    In conclusion, the results in this thesis provide significant contributions in the search of dry eye therapeutics through studies of adenosine and acetylcholine receptor activation.

  • 136.
    Carlström, Sebastian
    Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences.
    Jämförelse av två vågfrontsanalysatorervid mätning av den högre ordningensaberrationer2010Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 137.
    Carneiro de Freitas, Rui
    et al.
    Hospital de Braga, Portugal.
    Freitas, Cristina
    Hospital de Braga, Portugal.
    Leite, Ricardo
    Hospital de Braga, Portugal.
    Sousa, Keissy
    Hospital de Braga, Portugal.
    Mendes-Ferreira, José
    Hospital de Braga, Portugal.
    Soares, Andreia
    Hospital de Braga, Portugal.
    Rubin, Gary S.
    UCL-Institute of Ophthalmology, UK.
    Rocha-Sousa, Amandio A.
    University of Porto, Portugal.
    Santana, Rui
    Nova University of Lisbon, Portugal.
    Macedo, António Filipe
    University of Minho, Portugal.
    Prevalence of Visual Impairment in Portugal: study design and initial results2015In: Investigative Ophthalmology and Visual Science, ISSN 0146-0404, E-ISSN 1552-5783, Vol. 56, no 7, article id 2119Article in journal (Refereed)
    Abstract [en]

    Purpose 

    Information about the prevalence of visual impairment is fundamental to define policies that deal with vision loss. The aim of this study is to determine the prevalence of visual impairment (VI) in the population looking for eye care in public hospitals in Portugal.

    Methods 

    We designed an observation, cross-sectional prospective study (Prevalence and Costs of Visual Impairment in Portugal: PC-VIP study) to investigate the prevalence of VI in patients attending outpatient appointments in four public hospitals in Portugal. Hospital selected provide from general eye care (3-6 ophthalmologists) to high-specialized eye care (40+ ophthalmologists) that in total have between 120-140K hospital appointments per year. Files of patients are analysed weekly to detect patients with VI. Inclusion criteria were: visual acuity equal or worse than 0.5 (USA definition 20/40) in the better eye and/or a visual field of less than 20deg. Cases are selected by trained hospital staff and inserted in a database. Data collected included demographic information, acuity from both eyes, qualitative information about visual field (good, reduced, requires investigation), main diagnosis, secondary diagnosis and comorbidities. Diagnoses were classified according with ICD9.

    Results 

    We have now detected 2462 cases of VI that correspond to 4 to 33 weeks of data collection. The number of weeks is variable because collection did not start simultaneously in all sites. From the number of cases detected, 58% were female, 1.9% were under 20y, 8.2% were between 20y and 50y and 89.9% were ≥50y. The mean prevalence of visual impairment was 13.6% (SD=5.6) using the USA definition and it was 7.0%(SD=4.1) using the WHO definition (acuity equal or worse than 0.3 or ~20/63). With a methodology that controls for demographics the lowest and highest estimates were calculated. Considering the USA definition, the prevalence in the general population would be in the range 0.4 -0.4% (age<40y) and 0.8-2.4% (age>=40y). Considering WHO definition, it would be 0.2-0.5% (age<40y) and 0.4-1.0% (age>=40y).

    Conclusions 

    A hospital-based study can provide effective estimates of the prevalence of visual impairment in a population. Estimates for the country are in agreement with the expected results that can be deducted from neighbour countries and self-reported visual impairment in census 2001.

  • 138.
    Chandrasekaran, Davidpremkumar
    et al.
    Örebro University Hospital.
    Andersson, Åsa
    Örebro University Hospital.
    Hindenborg, Maria
    Örebro University Hospital.
    Norlin, Rolf
    Örebro University Hospital.
    Akner, Gunnar
    Örebro University.
    Development of physical performance after acute hip fracture: An observational study in a regular clinical geriatric setting2014In: Geriatric Orthopaedic Surgery & Rehabilitation, E-ISSN 2151-4585, Vol. 5, no 3, p. 93-102Article in journal (Refereed)
    Abstract [en]

    Background and aim: Hip fracture is a leading cause of mortality, morbidity, and disability in older people. The aim of thepresent study was to prospectively assess the development of physical performance in patients with hip fracture after surgery.

    Setting: Prospective, observational study in a Swedish university hospital.

    Methods: Assessment of 102 consecutive patients(65 females), with a mean age of 82 years (range 35-98) without specific inclusion or exclusion criteria. Seven physical functionswere assessed using the following 4 measuring methods and 3 rating scales at baseline 7 to 10 days after surgery and follow-upafter 4 months (F4): 10-m habitual walking speed (HWS), timed up and go (TUG), 30-second chair stand test (CST), handgripstrength (HGS), Berg balance scale (BBS), functional ambulation category (FAC), and general mobility.

    Results: The 47% dropoutpatients were significantly older and more often lived alone or in nursing homes and used indoor walking aids. At baseline, themean HWS was 0.4/0.5 (females/males) m/s; TUG 53/30 s; CST 4/5 kg, and HGS 17.4/31.2 kg. The medians of BBS and FAC were20/20 and 4/4, respectively. There were significant mean improvements at F4 for all 4 measured functions, except for HGS inmales but for neither of the rating scales. There was a large heterogeneity in all assessed variables, both at baseline and regardingchange at 4 months. Therefore, the mean/median results are depicted in figures, showing all individual results at baseline and F4,compared to reference values and discussed in relation to degree of improvement.

    Conclusion: The observed large heteroge-neity at baseline as well as F4 makes it essentially meaningless to report means and median data of functional assessment ofpatients with hip fracture. There is a strong need for individualization in both health analysis and how the treatment programis targeted, carried through, and evaluated over time in patients with hip fracture

  • 139.
    Claesson, Andreas
    et al.
    Karolinska Institutet, Sweden.
    Herlitz, Johan
    University of Borås, Sweden.
    Svensson, Leif
    Karolinska Institutet, Sweden.
    Ottosson, Linn
    Sahlgrenska University Hospital, Sweden.
    Bergfeldt, Lennart
    Sahlgrenska University Hospital, Sweden.
    Engdahl, Johan
    Karolinska Institutet, Sweden;Danderyd Hospital, Sweden.
    Ericson, Caroline
    Sahlgrenska University Hospital, Sweden.
    Sandén, Petra
    Sahlgrenska University Hospital, Sweden.
    Axelsson, Christer
    University of Borås, Sweden.
    Bremer, Anders
    University of Borås, Sweden.
    Defibrillation before EMS arrival in western Sweden2017In: American Journal of Emergency Medicine, ISSN 0735-6757, E-ISSN 1532-8171, Vol. 35, no 8, p. 1043-1048, article id S0735-6757(17)30117-1Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Bystanders play a vital role in public access defibrillation (PAD) in out-of-hospital cardiac arrest (OHCA). Dual dispatch of first responders (FR) alongside emergency medical services (EMS) can reduce time to first defibrillation. The aim of this study was to describe the use of automated external defibrillators (AEDs) in OHCAs before EMS arrival.

    METHODS: All OHCA cases with a shockable rhythm in which an AED was used prior to the arrival of EMS between 2008 and 2015 in western Sweden were eligible for inclusion. Data from the Swedish Register for Cardiopulmonary Resuscitation (SRCR) were used for analysis, on-site bystander and FR defibrillation were compared with EMS defibrillation in the final analysis.

    RESULTS: Of the reported 6675 cases, 24% suffered ventricular fibrillation (VF), 162 patients (15%) of all VF cases were defibrillated before EMS arrival, 46% with a public AED on site. The proportion of cases defibrillated before EMS arrival increased from 5% in 2008 to 20% in 2015 (p<0.001). During this period, 30-day survival increased in patients with VF from 22% to 28% (p=0.04) and was highest when an AED was used on site (68%), with a median delay of 6.5min from collapse to defibrillation. Adjusted odds ratio for on-site defibrillation versus dispatched defibrillation for 30-day survival was 2.45 (95% CI: 1.02-5.95).

    CONCLUSIONS: The use of AEDs before the arrival of EMS increased over time. This was associated with an increased 30-day survival among patients with VF. Thirty-day survival was highest when an AED was used on site before EMS arrival.

  • 140.
    Classon, Lisa
    Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences.
    Vanor och compliance hos kontaktlinsbärare:  En enkätstudie2011Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Bakgrund: Många studier gällande compliance har genomförts och flertalet har visat att nivån av compliance är låg. De huvudsakliga områdena där compliance brister är handhygien, rengöring av linsetui, överbärande av kontaktlinser, brist på fullgod uppföljning och felaktigt användande av linsvätskor. Några av dessa områden har tagits upp i denna studie.

    Syfte: Syftet med examensarbetet var att undersöka hur kontaktlinsbärandet ser ut hos ett litet antal Internetanvändande personer i Sverige. Personernas vanor och compliance studerades i relation till tidigare studier inom detta område.

    Metod: En webbenkät med, för syftet, relevanta frågor skapades i webbprogrammet Google Docs. Enkäten bifogades i en länk och presenterades som ett evenemang på Facebook. Personer som använde kontaktlinser uppmanades att svara på enkäten. Resultaten från enkäten samlades i Google Docs och därifrån kunde svaren analyseras.

    Resultat: Enkäten gav 84 svar. Majoriteten var kvinnor och studerande. Vanligast var användandet av månads-/tvåveckorslinser och på en daglig basis. Både kvinnor och män valde i högre grad att köpa sina kontaktlinser hos optiker men män var något överrepresenterade för köp av kontaktlinser på Internet. 22,6 % uppgav att de ofta bar samma par kontaktlinser längre än rekommenderat, 40,5 % gjorde en linskontroll varje år, 31,0 % sov med linser ibland, 13,1 % visste inte om deras kontaktlinser var godkända att sova i och 61,9 % uppgav att de någon eller några gånger behövt avstå från att använda kontaktlinser på grund av ögonproblem.

    Slutsats: Denna studie visade, likt andra studier, att non-compliance är ganska vanligt. Ett fortsatt arbete med att höja nivån av compliance är viktigt för att undvika allvarliga komplikationer och för att minska antalet användare som avbryter sitt bärande.

  • 141.
    Crossland, Michael D.
    et al.
    Anglia Ruskin University, UK ; Moorfields Eye Hospital NHS Foundation Trust, UK.
    Silva, Rui S.
    University of Minho, Portugal.
    Macedo, António Filipe
    University of Minho, Portugal.
    Smartphone, tablet computer and e-reader use by people with vision impairment2014In: Ophthalmic & physiological optics, ISSN 0275-5408, E-ISSN 1475-1313, Vol. 34, no 5, p. 552-557Article in journal (Refereed)
    Abstract [en]

    PURPOSE:

    Consumer electronic devices such as smartphones, tablet computers, and e-book readers have become far more widely used in recent years. Many of these devices contain accessibility features such as large print and speech. Anecdotal experience suggests people with vision impairment frequently make use of these systems. Here we survey people with self-identified vision impairment to determine their use of this equipment.

    METHOD:

    An internet-based survey was advertised to people with vision impairment by word of mouth, social media, and online. Respondents were asked demographic information, what devices they owned, what they used these devices for, and what accessibility features they used.

    RESULTS:

    One hundred and thirty-two complete responses were received. Twenty-six percent of the sample reported that they had no vision and the remainder reported they had low vision. One hundred and seven people (81%) reported using a smartphone. Those with no vision were as likely to use a smartphone or tablet as those with low vision. Speech was found useful by 59% of smartphone users. Fifty-one percent of smartphone owners used the camera and screen as a magnifier. Forty-eight percent of the sample used a tablet computer, and 17% used an e-book reader. The most frequently cited reason for not using these devices included cost and lack of interest.

    CONCLUSIONS:

    Smartphones, tablet computers, and e-book readers can be used by people with vision impairment. Speech is used by people with low vision as well as those with no vision. Many of our (self-selected) group used their smartphone camera and screen as a magnifier, and others used the camera flash as a spotlight.

  • 142.
    Crossland, Michael
    et al.
    Moorfields Eye Hospital NHS Foundation Trust, UK ; Anglia Ruskin University, UK.
    Macedo, António Filipe
    University of Minho, Portugal.
    Use of tablet computers and e-readers by people with visual impairment2014In: Clinical and experimental optometry, ISSN 0816-4622, E-ISSN 1444-0938, Vol. 97, p. e19-e19, article id 53Article in journal (Refereed)
    Abstract [en]

    Background: We have observed many people with visual impairment using tablet computers and electronic books and have previously shown that these devices can be used by people with relatively low visual acuity and contrast sensitivity.

    Method: An online survey was advertised to people with visual impairment using personal contacts, social media and online discussion groups. Participants were asked to specify whether they used tablet computers and/or electronic books and if so, which device they used, what they used the device for and which accessibility functions they used.

    Results: Forty-four of 75 (59 per cent) respondents used a tablet computer. Of these, 30 (65 per cent) used an Apple iPad. All tablet users accessed the internet on their device and more than half read electronic books, took photographs and used apps. The ability to enlarge print was seen as the most useful accessibility option, cited by 76 per cent. Forty-nine per cent used contrast adjustment and 58 per cent used speech. Only 16 of the 75 respondents (22 per cent) used an electronic reader. Enlarged print was the most popular accessibility option on ereaders.

    Conclusions: Tablet computers are widely used by people with visual impairment. Large print is the most commonly used accessibility option, although speech and contrast reversal are also frequently used.

  • 143.
    Crossland, Michael
    et al.
    UCL Institute of Ophthalmology, UK.
    Macedo, António Filipe
    UCL Institute of Ophthalmology, UK.
    Rubin, Gary
    UCL Institute of Ophthalmology, UK.
    Electronic books as low vision aids2010In: British Journal of Ophthalmology, ISSN 0007-1161, E-ISSN 1468-2079, Vol. 94, no 8, p. 1109-Article in journal (Refereed)
    Abstract [en]

    Recently, several electronic book readers have become commercially available. These consist of a low glare electronic paper screen and internal memory, which can typically hold the full text of between 150 and 2000 full-length novels. Electronic paper has a wide viewing angle of almost 1808 but a slow refresh speed of about 250 ms. Amazon’s Kindle device has 300 000 books available in electronic format, and 11 000 are available through Waterstones in the UK for the Sony Reader. Table 1 shows the parameters of these and other popular electronic books. Here, we explore the utility of these two electronic books for use by the visually impaired.

  • 144.
    Dahlberg, Simon
    Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences.
    Comparison between Corneal and Internal Contribution of Ocular Aberrations with Age2010Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 145. Dallongeville, Jean
    et al.
    Banegas, José R
    Tubach, Florence
    Guallar, Eliseo
    Borghi, Claudio
    De Backer, Guy
    Halcox, Julian P J
    Massó-González, Elvira L
    Perk, Joep
    Linnaeus University, Faculty of Health, Social Work and Behavioural Sciences, School of Health and Caring Sciences.
    Sazova, Ogün
    Steg, Philippe Gabriel
    Artalejo, Fernando Rodriguez
    Survey of physicians' practices in the control of cardiovascular risk factors: the EURIKA study.2012In: European journal of preventive cardiology, ISSN 2047-4881, Vol. 19, no 3, p. 541-550Article in journal (Refereed)
    Abstract [en]

    OBJECTIVES: To assess the practices of physicians in 12 European countries in the primary prevention of cardiovascular disease (CVD).

    METHODS: In 2009, 806 physicians from 12 European countries answered a questionnaire, delivered electronically or by post, regarding their assessment of patients with cardiovascular risk factors, and their use of risk calculation tools and clinical practice guidelines (ClinicalTrials.gov number: NCT00882336). Approximately 60 physicians per country were selected (participation rate varied between 3.1% in Sweden and 22.8% in Turkey).

    RESULTS: Among participating physicians, 85.2% reported using at least one clinical guideline for CVD prevention. The most popular were the ESC guidelines (55.1%). Reasons for not using guidelines included: the wide choice available (47.1%), time constraints (33.3%), lack of awareness of guidelines (27.5%), and perception that guidelines are unrealistic (23.5%). Among all physicians, 68.5% reported using global risk calculation tools. Written charts were the preferred method (69.4%) and the most commonly used was the SCORE equation (35.4%). Reasons for not using equations included time constraints (59.8%), not being convinced of their usefulness (21.7%) and lack of awareness (19.7%). Most physicians (70.8%) believed that global risk-equations have limitations; 89.8% that equations overlook important risk factors, and 66.5% that they could not be used in elderly patients. Only 46.4% of physicians stated that their local healthcare framework was sufficient for primary prevention of CVD, while 67.2% stated that it was sufficient for secondary prevention of CVD.

    CONCLUSIONS: A high proportion of physicians reported using clinical guidelines for primary CVD prevention. However, time constraints, lack of perceived usefulness and inadequate knowledge were common reasons for not using CVD prevention guidelines or global CVD risk assessment tools.

  • 146.
    Danielsson, Tom
    et al.
    Linnaeus University, Faculty of Social Sciences, Department of Sport Science.
    Schreyer, Hendrik
    Kalmar County Hospital, Sweden.
    Woksepp, Hanna
    Kalmar County Hospital, Sweden.
    Johansson, Therese
    Kalmar County Hospital, Sweden.
    Bergman, Patrick
    Linnaeus University, Faculty of Social Sciences, Department of Sport Science.
    Månsson, Alf
    Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences.
    Carlsson, Jörg
    Linnaeus University, Faculty of Health and Life Sciences, Department of Health and Caring Sciences. Kalmar County Hospital, Sweden.
    Two-peaked increase of serum myosin heavy chain-α after triathlon suggests heart muscle cell death2019In: BMJ Open Sport & Exercise Medicine, ISSN 2055-7647, Vol. 5, article id e000486Article in journal (Refereed)
    Abstract [en]

    Objective It has been suggested that the mechanism behind cardiac troponin elevation after strenuous exercise is passage through a cell membrane with changed permeability rather than myocardial cell death. We hypothesised that an increase of cardiac specific myosin heavy chain-alpha (MHC-α; 224 kDa compared with cardiac troponin T’s (cTnT) 37 kDa) could hardly be explained by passage through a cell membrane.

    Methods Blood samples were collected from 56 athletes (15 female, age 42.5±9.7, range 24–70 years) before, directly after and on days 1–8 after an Ironman. Biomarkers (C reactive protein (CRP), cTnT, creatinekinase (CK), MHC-α, myoglobin (MG), creatinine (C) and N-terminal prohormone of brain natriuretic peptide (NTproBNP) were measured.

    Results The course of MHC-α concentration (μg/L) was 1.33±0.53 (before), 2.57±0.78 (directly after), 1.51±0.53 (day 1), 2.74±0.55 (day 4) and 1.83±0.76 (day 6). Other biomarkers showed a one-peaked increase with maximal values either directly after the race or at day 1: cTnT 76 ±80 ng/L (12–440; reference<15), NT-proBNP 776±684 ng/L (92–4700; ref.<300), CK 68±55 μkat/L (5–280; ref.<1.9), MG 2088±2350 μg/L (130–17 000; ref.<72) and creatinine 100±20 μmol/L (74–161; ref.<100), CRP 49±23 mg/L(15–119; ref.<5).

    Conclusion MHC-α exhibited a two-peaked increase which could represent a first release from the cytosolic pool and later from cell necrosis. This is the first investigation of MHC-α plasma concentration afterexercise.

  • 147.
    Darreh-Shori, Taher
    et al.
    Karolinska Institutet.
    Vijayaraghavan, Swetha
    Karolinska Institutet.
    Aeinehband, Shahin
    Karolinska University Hospital Solna.
    Piehl, Fredrik
    Karolinska University Hospital Solna.
    Lindblom, Rickard P. F.
    Karolinska University Hospital Solna.
    Nilsson, Bo
    Uppsala University.
    Nilsson Ekdahl, Kristina
    Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences. Uppsala University.
    Långström, Bengt
    Uppsala University;Imperial College, UK;Odense University Hospital, University of Southern Denmark, Denmark.
    Almkvist, Ove
    Karolinska Institutet;Stockholm University.
    Nordberg, Agneta
    Karolinska Institutet;Karolinska University Hospital Huddinge.
    Functional variability in butyrylcholinesterase activity regulates intrathecal cytokine and astroglial biomarker profiles in patients with Alzheimer's disease2013In: Neurobiology of Aging, ISSN 0197-4580, E-ISSN 1558-1497, Vol. 34, no 11, p. 2465-2481Article in journal (Refereed)
    Abstract [en]

    Butyrylcholinesterase (BuChE) activity is associated with activated astrocytes in Alzheimer's disease brain. The BuChE-K variant exhibits 30%-60% reduced acetylcholine (ACh) hydrolyzing capacity. Considering the increasing evidence of an immune-regulatory role of ACh, we investigated if genetic heterogeneity in BuChE affects cerebrospinal fluid (CSF) biomarkers of inflammation and cholinoceptive glial function. Alzheimer's disease patients (n = 179) were BCHE-K-genotyped. Proteomic and enzymatic analyses were performed on CSF and/or plasma. BuChE genotype was linked with differential CSF levels of glial fibrillary acidic protein, S100B, interleukin-1 beta, and tumor necrosis factor (TNF)-alpha. BCHE-K noncarriers displayed 100%-150% higher glial fibrillary acidic protein and 64%-110% higher S100B than BCHE-K carriers, who, in contrast, had 40%-80% higher interleukin-1b and 21%-27% higher TNF-alpha compared with noncarriers. A high level of CSF BuChE enzymatic phenotype also significantly correlated with higher CSF levels of astroglial markers and several factors of the innate complement system, but lower levels of proinflammatory cytokines. These individuals also displayed beneficial paraclinical and clinical findings, such as high cerebral glucose utilization, low beta-amyloid load, and less severe progression of clinical symptoms. In vitro analysis on human astrocytes confirmed the involvement of a regulated BuChE status in the astroglial responses to TNF-alpha and ACh. Histochemical analysis in a rat model of nerve injury-induced neuroinflammation, showed focal assembly of astroglial cells in proximity of BuChE-immunolabeled sites. In conclusion, these results suggest that BuChE enzymatic activity plays an important role in regulating intrinsic inflammation and activity of cholinoceptive glial cells and that this might be of clinical relevance. The dissociation between astroglial markers and inflammatory cytokines indicates that a proper activation and maintenance of astroglial function is a beneficial response, rather than a disease-driving mechanism. Further studies are needed to explore the therapeutic potential of manipulating BuChE activity or astroglial functional status. (C) 2013 Elsevier Inc. All rights reserved.

  • 148. De Backer, G.
    et al.
    Catapano, A. L.
    Chapman, J.
    Graham, I.
    Reiner, Z.
    Perk, Joep
    Linnaeus University, Faculty of Health and Life Sciences, Department of Health and Caring Sciences.
    Wiklund, O.
    Guidelines on CVD prevention: Confusing or complementary?2013In: Atherosclerosis, ISSN 0021-9150, E-ISSN 1879-1484, Vol. 226, no 1, p. 299-300Article in journal (Other academic)
  • 149. De Backer, Guy
    et al.
    Catapano, Alberico L
    Chapman, John
    Graham, Ian
    Reiner, Zeljko
    Perk, Joep
    Linnaeus University, Faculty of Health and Life Sciences, Department of Health and Caring Sciences.
    Wiklund, Olov
    Guidelines on CVD prevention: confusing or complementary?2013In: European Journal of Preventive Cardiology, ISSN 2047-4873, E-ISSN 2047-4881, Vol. 20, no 1, p. 6-8Article in journal (Other academic)
  • 150.
    Demirel, Isak
    et al.
    Univ Örebro, Dept Clin Med, Sch Hlth & Med Sci, Örebro, Sweden.
    Säve, Susanne
    Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences.
    Kruse, Robert
    Univ Örebro, Dept Clin Med, Sch Hlth & Med Sci, Örebro, Sweden.
    Persson, Katarina
    Univ Örebro, Dept Clin Med, Sch Hlth & Med Sci, Örebro, Sweden.
    Expression of suppressor of cytokine signalling 3 (SOCS3) in human bladder epithelial cells infected with uropathogenic Escherichia coli2013In: Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), ISSN 0903-4641, E-ISSN 1600-0463, Vol. 121, no 2, p. 158-167Article in journal (Refereed)
    Abstract [en]

    Suppressor of cytokine signalling (SOCS) proteins inhibit pro-inflammatory signalling mediated by Janus-activated kinase (JAK)-signal transducer and activator of transcription (STAT) pathways. To evade the immune response some pathogens appear to modify the host SOCS proteins. Uropathogenic Escherichia coli (UPEC) are able to subvert the host response evoked by bladder epithelial cells, but the mechanisms are not fully understood. The objective of this study was to investigate whether UPEC can modify the host SOCS and STAT3 response. Real time RT-PCR studies demonstrated an increased SOCS1 and SOCS3 expression in the isolated human bladder epithelial cell lines (RT-4 and 5637) in response to cytokines. UPEC strain IA2 increased SOCS3, but not SOCS1, mRNA levels with a peak at 6h after infection. The increase of SOCS3 was confirmed at the protein level by Western blotting. The UPEC strain IA2 caused a time-dependent decrease in the phosphorylation of STAT3. This study demonstrates that UPEC are able to affect SOCS3 and STAT3 signalling in human uroepithelial cells. The finding that UPEC are able to induce mediators involved in suppression of host cytokine signalling may help to elucidate how UPEC may circumvent the host response during urinary tract infection.

1234567 101 - 150 of 606
CiteExportLink to result list
Permanent link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf