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  • 31801.
    Voulgaridis, Elias
    et al.
    Aristotle University, Greece.
    Passialis, Costas
    Aristotle University, Greece.
    Adamopoulos, Stergios
    Linnaeus University, Faculty of Technology, Department of Forestry and Wood Technology.
    Foti, Dafni
    Aristotle University, Greece.
    Voulgaridou, Eleni
    Aristotle University, Greece.
    ΠΑΡΑΓΩΓΗ ΚΑΙ ΙΔΙΟΤΗΤΕΣ ΠΕΙΡΑΜΑΤΙΚΩΝ ΠΛΙΝΘΩΝ ΕΣΩΤΕΡΙΚΗΣ ΤΟΙΧΟΠΟΙΙΑΣ ΑΠΟ ΓΥΨΟ ΚΑΙ ΑΝΑΚΥΚΛΟΥΜΕΝΑ ΥΛΙΚΑ ΞΥΛΟΥ ΚΑΙ ΕΛΑΣΤΙΚΩΝ ΟΧΗΜΑΤΩΝ: [ Production and properties of experimental bricks for interior walls from gypsum and recycled materials of wood and rubber ]2017In: ΠΡΑȀΤǿȀΑ : 18ου Πανελλήνιου Δασολογικού Συνεδρίου : “Η Ελληνική Δασοπονία μπροστά σε σημαντικές προκλήσεις: αειφορική διαχείριση δασών, δασικοί χάρτες, περιβαλλοντικές τεχνολογίες – δικτύωση και προστασία φυσικού περιβάλλοντος”: & International Workshop : “Information Technology, Sustainable Development, Scientific Network & Nature Protection” : 8-11 Οκτωβρίου 2017, ΕΔΕΣΣΑ ΠΕȁȁΑΣ, Περιοχή Βαρόσι, Hellenic Forestry Society , 2017, p. 315-323Conference paper (Refereed)
    Abstract [en]

    Τhe manufacturing and testing of gypsum bonded solid bricks with wood chips from particleboard production residues and rubber and textile fibers from waste tires was investigated. The recovered rubber and wood materials were mixed in gypsum/water solutions for the fabrication of standard solid bricks with six holes by using appropriate molds. After drying, the compressive strength, the thermal conductivity, the air-flow resistance, the sound absorption coefficient and the emissions of volatile organic compounds (VOC) of the bricks were determined. The compressive strength of solid bricks was much greater than that required in interior walls. The bricks showed a better thermal insulation than both the extruded and pressed house bricks but lower than the insulating bricks. Emissions of volatile organic compounds of bricks were at acceptable levels according to regulations for construction products. The sound absorption coefficient of the solid bricks was 0,72 for the frequency of 1 kHz and decreased with increasing frequency. In addition, information on the raw materials and production cost are given.

  • 31802. Voulgaridis, Elias
    et al.
    Passialis, Costas
    Adamopoulos, Stergios
    Triantafyllos, D
    Identification of wood and charcoal specimens from the ancient tomb of Mikri Doxipara-Zoni, Evros Prefecture2008In: National Archaeological Conference, March 13-15, Thessaloniki, Greece, 2008Conference paper (Other academic)
  • 31803.
    Voulgaridis, Elias
    et al.
    Aristotle University of Thessaloniki, Greece.
    Passialis, Costas
    Aristotle University of Thessaloniki, Greece.
    Karastergiou, Sotirios
    Technological Educational Institute of Thessaly, Greece.
    Adamopoulos, Stergios
    Technological Educational Institute of Thessaly, Greece.
    Kakaras, Ioannis
    Technological Educational Institute of Thessaly, Greece.
    Foti, Dafni
    Aristotle University of Thessaloniki, Greece.
    Koutsianitis, Dimitrios
    Aristotle University of Thessaloniki, Greece.
    Voulgaridou, Eleni
    Aristotle University of Thessaloniki, Greece.
    Effect of laser drilling on impregnability of fir (Abies borisii regis) and spruce (Picea excelsa) wood2014In: Wood Structure, Properties and Quality – 2014: 5th RCCWS International Symposium, Moscow State University Press, 2014, p. 51-56Conference paper (Refereed)
    Abstract [en]

    Fir and spruce wood specimens, 2×2 cm in cross section and 34 cm long, were pre-pared with true radial and tangential surfaces. All lateral surfaces of the wood specimens were drilled by laser beams to a depth of 0,4 cm (1/5 of specimen thickness) with two drilling patterns (distance between holes 1×1 cm and 1×2 cm) in order to improve the wood permea-bility of these refractory to impregnation species. After drilling and assessing the drilling ef-fect on mechanical properties of wood, wood specimens, 10 cm long, were impregnated with oil and CCB preservatives by using vacuum (0,6 mmHg) and pressure (1,5 bar) for 15 minutes and 30 minutes, respectively. The effects of the two laser drilling patterns on impreg-nability of fir and spruce wood specimens were measured and assessed. The results showed that both drilling patterns created by laser beams on all lateral surfaces of fir and spruce wood specimens at 0,4 mm depth improved the retention and penetration of preservatives in fir and spruce wood specimens. This effect was more pronounced in fir than in spruce. Between the two drilling patterns, the pattern with distances between holes 1×1 cm was more effective than that with distances 1×2 cm, in both species tested.

  • 31804.
    Voulgaridis, Elias
    et al.
    Aristotle Univ Thessaloniki, Greece.
    Passialis, Costas
    Aristotle Univ Thessaloniki, Greece.
    Negri, Martino
    Ivalsa Cnr, Trees & Timber Inst, Italy.
    Adamopoulos, Stergios
    Technol Educ Inst Larissa, Greece.
    Shear bond strength of black locust wood glued with three adhesive systems2012In: Wood research, ISSN 1336-4561, Vol. 57, no 3, p. 489-496Article in journal (Refereed)
    Abstract [en]

    Black locust wood was bonded with three commercial adhesives (PVAc, PU, epoxy) and tested for its shear bond strength against process (treatments I and II) and surface parameters (radial, tangential, roughness). For treatment I (applied pressure 8 bar, press time 1.5 h, curing time 24 h), the mean shear bondstrength was found to be 6.95 N.mm(-2), 5.54 N.mm(-2) and 10.53 N.mm(-2) corresponding to the three adhesives tested, respectively. Increase in press and curing time in treatment II (press time 3 h, curing time 7 days) significantly improved the gluing performance of adhesives, 9.58 N.mm(-2) for PVAc, 13.32 N.mm(-2) for PU and 15.03 N.mm(-2) for epoxy. Surface of gluing (radial, tangential) did not affect the shear bond strength significantly. Failure within wood was found to be up to 40 % for treatment I (PVAc, epoxy) and up to 85 % for treatment II (epoxy). Positive linear regressions were calculated between shearbond strength and wood failure only for PU and epoxy adhesives. Shear bond strength was not related to surface roughness for any adhesive.

  • 31805.
    Voyer, Andrea
    Yale Univ, Ctr Cultural Sociol, New Haven, CT 06520 USA .
    Disciplined to diversity: learning the language of multiculturalism2011In: Ethnic and Racial Studies, ISSN 0141-9870, E-ISSN 1466-4356, Vol. 34, no 11, p. 1874-1893Article in journal (Refereed)
    Abstract [en]

    This study shows that contemporary multiculturalism is a cultural referent used in the construction of modern and socially-acceptable selves. By analysing the practices of diversity training, I consider one of the ways in which multiculturalism moves from abstract philosophical idea and fodder for policy formation to adoption as a cultural and moral framework that individuals use in establishing their identities, discerning meaning and engaging others. Demonstrating that people must acquire competence in the use of a particular multicultural vocabulary and rules of interaction, I challenge the perspective that both bigotry and acceptance are organic to individuals. Properly multicultural selves are not merely the natural extension of interior individual qualities. Instead, people produce modern identities vis-à-vis diversity through the use of language and the negotiation of its meaning.

  • 31806.
    Voyer, Andrea
    Linnaeus University, Faculty of Social Sciences, Department of Education.
    Notes on a cultural sociology of immigrant incorporation2013In: American Journal of Cultural Sociology, ISSN 2049-7113, Vol. 1, no 1, p. 26-41Article in journal (Refereed)
    Abstract [en]

    I lay out a scheme for understanding immigrant incorporation as social solidarity achieved through the application of widely shared meanings, categories of perception, moral distinctions and manners of speech pertaining to social membership. The inclusion of immigrants is accomplished through the symbolic construction of community boundaries that include newcomers, the reification of symbolic distinctions in identifiable practices, and the censure and exclusion of problematic elements of diversity. This cultural sociology of immigrant incorporation draws upon Alexander's work on the multicultural mode of incorporation in the civil sphere, Bakhtin's thinking regarding centripetal and centrifugal forces in language, and Foucault's conception of discipline. Empirical material from Sweden and the United States supports the theory.

  • 31807.
    Voyer, Andrea
    Pace University.
    Strangers and Neighbors: Multiculturalism, Conflict and Community in America2013Book (Refereed)
    Abstract [sv]

    The city of Lewiston, Maine, has struggled since its mills began closing in the 1950s. Historically recognized for its large French-speaking population descended from the Canadians who staffed the city's mills, in the new millennium Lewiston acquired a new identity as "Maine's Mogadishu." Beginning in 2001, substantial Somali immigrant settlement gave Lewiston the largest per capita Somali population in the United States and sparked controversies and collaborations that redefined the city. In Strangers and Neighbors, Andrea M. Voyer shares five years of observations in the city of Lewiston. She shows how long-time city residents and immigrant newcomers worked to develop an understanding of the inclusive and caring community in which they could all take part. Yet the sense of community developed in Lewiston was built on the appreciation of diversity in the abstract rather than by fostering close and caring relationships across the boundaries of class, race, culture, and religion. Through her sensitive depictions of the experiences of Somalis, Lewiston city leadership, anti-racism activists, and even racists, Voyer reveals both the promise of and the obstacles to achieving community in the face of diversity.

  • 31808.
    Voyer, Andrea
    et al.
    Pace University, USA.
    Trondman, Mats
    Linnaeus University, Faculty of Arts and Humanities, Department of Cultural Sciences.
    Between theory and social reality: Ethnography and Interpretation and Social Knowledge: Introduction to the special issue2017In: Ethnography, ISSN 1466-1381, E-ISSN 1741-2714, Vol. 18, no 1, p. 3-9Article in journal (Refereed)
    Abstract [en]

    Difficulties distinguishing the ethnographic object and the ethnographer's analysis can pose a challenge to the conduct and dissemination of ethnographic work. The close distance between ethnographic observation and the ethnographer's interpretation elides the boundary between considerations of theory and method. In his book, Interpretation and Social Knowledge, Reed describes interpretivism as an epistemological approach aimed at harnessing the potential of social explanations developed in ethnography's interstitial position – the space between theory and social reality. This issue ofEthnographyc provides a forum for ethnographers coming from different theoretical positions and working in different empirical areas to reflect upon on the value and limitations of interpretivism in ethnography.

  • 31809.
    Vrana, Radovan
    et al.
    University of Zagreb.
    Badurina, Boris
    University of Zagreb.
    Golub, Koraljka
    University of Zagreb.
    Advantages and disadvantages of use of digital collections in the process of education1999In: Learning society, learning organisation, lifelong learning : proceedings of the 7th International BOBCATSSS-Symposium, 25th-27th January 1999, Bratislava, Slovak Republic, Darmstadt: Fachhochschule Darmstadt, University of Applied Sciences, Dept. of Information Science , 1999, p. 484-495Conference paper (Other academic)
    Abstract [en]

    In last few years the Internet has become a true component part of the process of education in many countries in Europe. This global computer network has brought us many types of applications of computer technology suitable for learning. However, there are still some methods and procedures which are part of this global network and are still not sufficiently used. As a result of this opinion, a small group of students of the 4th year of library and information sciences at the Faculty of Philosophy in Zagreb, proposed a project which, they think, would solve the problem of inadequate quantity of printed exam materials at the Faculty necessary for the successful completion of exams by use of a digital collection containing equivalent ready-for-use material in electronic form.

  • 31810.
    Vredenburg, Jana
    et al.
    Uppsala University.
    Varela, Ana Rita
    Univ Catolica Portuguesa Porto, CBQF Ctr Biotecnol Quim Fina, Lab Associado, Escola Super Biotecnol, P-4200072 Oporto, Portugal.
    Hasan, Badrul
    Uppsala University.
    Bertilsson, Stefan
    Uppsala University.
    Olsen, Björn
    Uppsala University.
    Narciso-da-Rocha, Carlos
    Univ Catolica Portuguesa Porto, CBQF Ctr Biotecnol Quim Fina, Lab Associado, Escola Super Biotecnol, P-4200072 Oporto, Portugal.
    Bonnedahl, Jonas
    Linnaeus University, Faculty of Health and Life Sciences, Department of Biology and Environmental Science.
    Stedt, Johan
    Linnaeus University, Faculty of Health and Life Sciences, Department of Biology and Environmental Science.
    Da Costa, Paulo Martins
    Univ Porto, ICBAS Inst Ciencias Biomed Abel Salazar, P-4100 Oporto, Portugal.
    Manaia, Celia M.
    Univ Catolica Portuguesa Porto, CBQF Ctr Biotecnol Quim Fina, Lab Associado, Escola Super Biotecnol, P-4200072 Oporto, Portugal.
    Quinolone-resistant Escherichia coli isolated from birds of prey in Portugal are genetically distinct from those isolated from water environments and gulls in Portugal, Spain and Sweden2014In: Environmental Microbiology, ISSN 1462-2912, E-ISSN 1462-2920, Vol. 16, no 4, p. 995-1004Article in journal (Refereed)
    Abstract [en]

    The influence of geographic distribution and type of habitat on the molecular epidemiology of ciprofloxacin resistant Escherichia coli was investigated. Ciprofloxacin resistant E. coli from wastewater, urban water with faecal contamination and faeces of gulls, pigeons and birds of prey, from Portugal, Spain and Sweden were compared based on multi-locus sequence typing (MLST) and quinolone resistance genetic determinants. Multi-locus sequence typing allowed the differentiation of E. coli lineages associated with birds of prey from those inhabiting gulls and waters. E. coli lineages of clinical relevance, such as the complex ST131, were detected in wastewater, streams and gulls in Portugal, Spain and Sweden. Quinolone resistance was due to gyrA and parC mutations, although distinct mutations were detected in birds of prey and in wastewater, streams and gulls isolates. These differences were correlated with specific MLST lineages, suggesting resistance inheritance. Among the plasmid-mediated quinolone resistance genes, only aac(6 ')-ib-cr and qnrS were detected in wastewater, streams and gulls isolates, but not in birds of prey. The horizontal transfer of the gene aac(6 ')-ib-cr could be inferred from its occurrence in different MLST lineages.

  • 31811. Vromant, Pieter
    et al.
    Weyns, Danny
    Linnaeus University, Faculty of Science and Engineering, School of Computer Science, Physics and Mathematics.
    Malek, Sam
    Andersson, Jesper
    Linnaeus University, Faculty of Science and Engineering, School of Computer Science, Physics and Mathematics.
    On interacting control loops in self-adaptive systems2011In: Proceedings of the 6th International Symposium on Software Engineering for Adaptive and Self-Managing Systems, ACM Press, 2011, p. 202-207Chapter in book (Refereed)
    Download full text (pdf)
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  • 31812.
    Vu, Viet
    et al.
    Blekinge Institute of Technology.
    Sjögren, Thomas
    Blekinge Institute of Technology.
    Pettersson, Mats
    Blekinge Institute of Technology.
    Håkansson, Lars
    Gustavsson, Anders
    Swedish Defence Research Agency.
    Ulander, Lars
    Swedish Defence Research Agency.
    RFI Suppression In Ultrawideband SAR Using Adaptive Line Enhancer2010In: IEEE Geoscience and Remote Sensing Letters, ISSN 1545-598X, E-ISSN 1558-0571, Vol. 7, no 4, p. 694-698Article in journal (Refereed)
    Abstract [en]

    In this letter, we propose an approach to suppress radio-frequency interference (RFI) in ultrawideband (UWB) low-frequency synthetic aperture radar (SAR). According to the proposal, RFI is suppressed by using an adaptive line enhancer controlled by the normalized least mean square algorithm. The approach is tested successfully on real UWB low-frequency SAR data. In order to keep the computational burden down, possible ways to integrate the RFI suppression approach into SAR imaging algorithms are also suggested.

  • 31813. Vult von Steyern, F
    et al.
    Josefsson, J-O
    Tågerud, Sven
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Rhodamine B, a fluorescent probe for acidic organelles in denervated skeletal muscle1996In: Journal of Histochemistry and Cytochemistry, Vol. 44, p. 267-274Article in journal (Refereed)
  • 31814. Vult von Steyern, F
    et al.
    Kanje, M
    Tågerud, Sven
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Protein secretion from mouse skeletal muscle. Coupling of increased exocytotic and endocytotic activities in denervated muscle1993In: Cell and Tissue Research, Vol. 274, p. 49-56Article in journal (Refereed)
  • 31815. Vult von Steyern, F
    et al.
    Libelius, Rolf
    Lawoko, G
    Tågerud, Sven
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Endocytotic activity of mouse skeletal muscle fibres after long-term denervation1994In: Journal of the Neurological Sciences, Vol. 125, p. 147-152Article in journal (Refereed)
  • 31816.
    Vumma, Ravi
    et al.
    Örebro University.
    Bang, Charlotte Sahlberg
    Örebro University.
    Kruse, Robert
    Örebro University.
    Johansson, Kjell
    Örebro University.
    Persson, Katarina
    Örebro University.
    Antibacterial effects of nitric oxide on uropathogenic Escherichia coli during bladder epithelial cell colonization: a comparison with nitrofurantoin2016In: Journal of antibiotics (Tokyo. 1968), ISSN 0021-8820, E-ISSN 1881-1469, Vol. 69, no 3, p. 183-186Article in journal (Refereed)
    Abstract [en]

    Uropathogenic Escherichia coli (UPEC) is the predominant causative organism of urinary tract infections (UTI) with a high recurrence rate.1 Recurrence of UTI may involve intracellular localization of bacterial colonies within the bladder mucosa, a process that could benefit the bacteria in terms of protection against antibiotics and host immune cells.2, 3 Once internalized, UPEC may multiply and form intracellular bacterial communities with biofilm-like properties4 and/or enter a non-replicating stable and quiescent state that may serve as a source for recurrent UTI.2, 5, 6 A wide range of antimicrobial agents is used for the treatment of UTI but many antibiotics are unable to penetrate biofilm matrix or inhibit bacteria in a metabolically quiescent state. A recent study demonstrated that of seven different functional classes of antibiotics only a few, including nitrofurantoin and some fluoroquinolones, were able to eliminate internalized UPEC within bladder epithelial cells. Nitric oxide (NO) is a small hydrophobic molecule with antibacterial properties that readily diffuses through lipid bilayer membranes. During infection various host cells produce NO enzymatically from inducible nitric oxide synthase and NO has a key role in the innate immune response. It has been shown previously that NO has antibacterial activity against UPEC isolates, including multidrug-resistant extended spectrum beta-lactamase-producing isolates. Although NO can interact directly with bacteria, it can also be oxidized to reactive nitrogen species.

  • 31817.
    Vumma, Ravi
    et al.
    Örebro University.
    Johansson, Jessica
    Örebro University.
    Lewander, Tommy
    Uppsala University Hospital.
    Venizelos, Nikolaos
    Örebro University.
    Tryptophan transport in human fibroblast cells-a functional characterization.2011In: International Journal of Tryptophan Research, ISSN 1178-6469, Vol. 4, p. 19-27Article in journal (Refereed)
    Abstract [en]

    There are indications that serotonergic neurotransmission is disturbed in several psychiatric disorders. One explanation may be disturbed transport of tryptophan (precursor for serotonin synthesis) across cell membranes. Human fibroblast cells offer an advantageous model to study the transport of amino acids across cell membranes, since they are easy to propagate and the environmental factors can be controlled. The aim of this study was to functionally characterize tryptophan transport and to identify the main transporters of tryptophan in fibroblast cell lines from healthy controls.Tryptophan kinetic parameters (V(max) and K(m)) at low and high concentrations were measured in fibroblasts using the cluster tray method. Uptake of (3)H (5)-L-tryptophan at different concentrations in the presence and absence of excess concentrations of inhibitors or combinations of inhibitors of amino acid transporters were also measured. Tryptophan transport at high concentration (0.5 mM) had low affinity and high V(max) and the LAT1 isoform of system-L was responsible for approximately 40% of the total uptake of tryptophan. In comparison, tryptophan transport at low concentration (50 nM) had higher affinity, lower V(max) and approximately 80% of tryptophan uptake was transported by system-L with LAT1 as the major isoform. The uptake of tryptophan at the low concentration was mainly sodium (Na(+)) dependent, while uptake at high substrate concentration was mainly Na(+) independent. A series of different transporter inhibitors had varying inhibitory effects on tryptophan uptake.This study indicates that tryptophan is transported by multiple transporters that are active at different substrate concentrations in human fibroblast cells. The tryptophan transport trough system-L was mainly facilitated by the LAT1 isoform, at both low and high substrate concentrations of tryptophan.

  • 31818.
    Vumma, Ravi
    et al.
    Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences.
    Johansson, Jessica
    Örebro University.
    Venizelos, Nikolaos
    Örebro University.
    Proinflammatory cytokines and oxidative stress decrease the transport of dopamine precursor tyrosine in human fibroblasts2017In: Neuropsychobiology, ISSN 0302-282X, E-ISSN 1423-0224, Vol. 75, no 4, p. 178-184Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Proinflammatory cytokines and oxidative stress responses have been extensively implicated in the pathophysiology of neuropsychiatric disorders over the past 2 decades. Moreover, disturbed transport of the dopamine precursor (i.e., the amino acid tyrosine) has been demonstrated, in different studies, across fibroblast cell membranes obtained from neuropsychiatric patients. However, the role and influences of proinflammatory cytokines and oxidative stress, and the reasons for disturbed tyrosine transport in neuropsychiatric disorders, are still not evaluated.

    AIMS: The present study aimed to assess the role of proinflammatory cytokines and oxidative stress, indicated in many neuropsychiatric disorders, in tyrosine transportation, by using human skin-derived fibroblasts.

    METHODS: Fibroblasts obtained from a healthy control were used in this study. Fibroblasts were treated with proinflammatory cytokines (IL-1β, IFN-γ, IL-6, TNF-α), their combinations, and oxidative stress, optimized for concentrations and incubation time, to analyze the uptake of 14C-tyrosine compared to untreated controls.

    RESULTS AND CONCLUSION: This study demonstrates that proinflammatory cytokines and oxidative stress decrease the transport of tyrosine (47% and 33%, respectively), which can alter dopamine synthesis. The functionality of the tyrosine transporter could be a new potential biomarker to target for discovering new drugs to counteract the effects of proinflammatory cytokines and oxidative stress in the pathophysiology of neuropsychiatric disorders.

  • 31819.
    Vumma, Ravi
    et al.
    Örebro University.
    Wiesel, Frits-Axel
    Uppsala University Hospital.
    Flyckt, Lena
    Danderyd's Hospital.
    Bjerkenstedt, Lars
    Linköping University.
    Venizelos, Nikolaos
    Örebro University.
    Functional characterization of tyrosine transport in fibroblast cells from healthy controls2008In: Neuroscience Letters, ISSN 0304-3940, E-ISSN 1872-7972, Vol. 434, no 1, p. 56-60Article in journal (Refereed)
    Abstract [en]

    Human fibroblast cells are an advantageous model to study the transport of amino acids across cell membranes, since one can control the environmental factors. A major problem in all earlier studies is the lack of precise and detailed knowledge regarding the expression and functionality of tyrosine transporters in human fibroblasts. This motivated us to perform a systematic functional characterization of the tyrosine transport in fibroblast cells with respect to the isoforms of system-L (LAT1, LAT2, LAT3, LAT4), which is the major transporter of tyrosine. Ten (n=10) fibroblast cell lines from healthy volunteers were included in the study. Uptake of L-[U-14C] tyrosine in fibroblasts was measured using the cluster tray method in the presence and absence of excess concentrations of various combinations of inhibitors. This study demonstrated that LAT1 is involved in 90% of total uptake of tyrosine and also around 51% of alanine. Not more than 10% can be accounted for by LAT2, LAT3 and LAT4 isoforms. LAT2 seems to be functionally weak in uptake of tyrosine while LAT3 and LAT4 contributed around 7%. 10% could be contributed by system-A (ATA2 isoform). Alanine consequently inhibited the tyrosine transport by up to 60%. Tyrosine transport through the LAT1 isoform has a higher affinity compared to system-L. In conclusion, the LAT1 isoform is the major transporter of tyrosine in human fibroblast cells. Competition between tyrosine and alanine for transport is shown to exist, probably between LAT1 and LAT2 isoforms. This study established fibroblast cells as a suitable experimental model for studying amino acid transport defects in humans.

  • 31820. Vystavna, Yulia
    et al.
    Kaczala, Fabio
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Sustainable Water Management and good sanitation through dry toilets. Case study Ukraine2006Conference paper (Other academic)
  • 31821.
    Vähätalo, Mervi
    et al.
    University of Turku, Finland.
    Kallio, Tomi J.
    University of Turku, Finland.
    Challenges of public procurement: measuring the processes or the outcome2015In: Paper presented at the 19th International Research Society for Public Management (IRSPM) Conference, Birmingham, UK, March 30-April 1, 2015, IRSPM , 2015Conference paper (Refereed)
    Abstract [en]

    Public procurement has been considered as an important instrument in triggering innovations and thereby supporting public economy. In recent years, innovation supportive procurement practices have been studied. However, conducting the public procurement of innovations is said to be challenging and several barriers that prohibit innovation in public procurement have also been reported. Due to the significant role of health and social services in public economy, we found it important to study whether innovation supportive procurement practices are used in health and social services. In addition, we studied the possible barriers to the public procurement of innovations in this context. We interviewed eighteen public purchasers from three different municipalities. Results revealed that innovation supportive purchasing practices were emerging in health and social services. However, purchasers reported several barriers to it. Many of the barriers were similar to those found in the previous studies. In addition results revealed barriers that were related to health and social service context in particular, such as the uncertainty of demand, challenges in outcome definition and measurement, the rigid regulation of the context, multiple supplier and complex environment as well as ethical sensitivity of the context. Results have significance when evaluating the applicability of public procurement of innovations in health and social service context.

  • 31822.
    Vähätalo, Mervi
    et al.
    University of Turku, Finland.
    Kallio, Tomi J.
    University of Turku, Finland.
    Enhancing innovations in public procurement2014In: Paper presented at the PASCAL workshop on Cities learning together – Public administration as a domain for smart solutions, Tampere, Finland, June 12-13, 2014, 2014Conference paper (Refereed)
  • 31823.
    Vähätalo, Mervi
    et al.
    University of Turku, Finland.
    Kallio, Tomi J.
    University of Turku, Finland.
    Managing supply chains in modular services: case study from health and social services2015In: Paper presented at the 6th International seminar on service architecture and modularity, Helsinki, Finland, January 15-16, 2015, IRSPM , 2015Conference paper (Refereed)
  • 31824.
    Vähätalo, Mervi
    et al.
    University of Turku, Finland.
    Kallio, Tomi J.
    University of Turku, Finland.
    Modularity: supporting innovations in public procurement2014In: Paper presented at the 5th International seminar on service architecture and modularity, Copenhagen, Denmark, January 16-17, 2014, 2014Conference paper (Refereed)
  • 31825.
    Vähätalo, Mervi
    et al.
    University of Turku, Finland.
    Kallio, Tomi J.
    University of Turku, Finland.
    Organising health services through modularity2015In: International Journal of Operations & Production Management, ISSN 0144-3577, E-ISSN 1758-6593, Vol. 35, no 6, p. 925-945Article in journal (Refereed)
    Abstract [en]

    Purpose - The purpose of this paper is to analyse the way in which the factors influencing a transformation towards or away from modularity, according to general modular systems theory, appear in the context of health services, and the extent to which the special characteristics of health services might support or prevent its application.

    Design/methodology/approach - The arguments constructed in the study are based on the theme of modularity, reflected against the special characteristics of health services identified in the context of health economics.

    Findings - The results include 11 proposition pairs that direct health services both towards and away from modularity.

    Research limitations/implications - Health services are highly heterogeneous in nature and the authors illustrate this with a wide range of examples from elderly care as the authors discuss the application of modularity in this context. Nevertheless, the authors recognise that modularity might suit some health services better than others. The findings provide potentially important information to health service managers and providers, enabling them to understand how modularity would benefit health service provision and where contradictions are to be expected.

    Originality/value - This study contributes to the discourse on service modularity in general, and complements the literature on modularity with reference to both public and private health services.

  • 31826.
    Vähätalo, Mervi
    et al.
    University of Turku, Finland.
    Kallio, Tomi J.
    University of Turku, Finland.
    Public procurement for innovations: barriers in health and social services2017In: Paper presented at the 21st International Research Society for Public Management (IRSPM) Conference, Budapest, Hungary, April 19-21, 2017, IRSPM , 2017Conference paper (Refereed)
    Abstract [en]

    Public procurement is considered a tool for both purchasing services and triggering innovation. However, public procurement for innovations (PPI) is considered to be a challenging process. Studies concerning PPI have been conducted from perspectives of e.g. risk management (Kalvet & Lember, 2010); demand-side policies (Edler & Georghiou, 2007; Edquist & Zabala-Iturriagagoitia, 2012); policy instruments (Vecchiato & Roveda, 2014; Georghiou et al., 2014); and practices that support or induce barriers to innovations (Rolfstam, 2012; Edler et al., 2011; Uyarra et al., 2014). However, very few studies explore PPI in health and social services (Yeow & Edler, 2012; Pelkonen & Valovirta, 2015). 

    According to the extant literature, innovations can be supported by using certain types of procurement practices e.g. outcome-based specifications, early interactions with suppliers, and requirements for innovation in tenders (Edler et al., 2011; Uyarra et al., 2014; Georghiou et al., 2014). By contrast, barriers that are said to prohibit PPI include e.g., over-specified tenders, the overall complexity of the procurement process, and the lack of early interaction between purchasers and providers (Uyarra et al., 2014). Furthermore, also context-related characteristics create challenges within PPI. For instance, in health and social services, manifold laws guide service production, which, in turn, influence the process of procurement (Pelkonen & Valovirta, 2015). Given the financial significance of public procurement of health services in the European Union, it is surprising how sparse academic research about PPI in health and social services has been. This paper explored public procurement in health and social services and the barriers to PPI. Following research questions were comprised: what innovations supportive procurement practices are applied in health and social services and what barriers prohibit their application? 

    The empirical data were collected with 18 interviews from four purchasing organizations in Finnish municipalities. These organizations used different strategies in organizing and in procuring health and social services. Analysis revealed that innovations supportive purchasing practices were emerging in this field. However, added to the barriers already mentioned in the extant literature, also several context-related barriers preventing PPI were found. Context-related barriers included uncertainty of demand, rigid regulation of context, an ethically sensitive context, multiple suppliers, and complex environments, as well as challenges in outcome definition and measurement. For example, according to the purchasers, uncertainty of demand prevented long contracts. Despite the fact that outcome based procurement would allow providers to adjust to demand, purchasers were unwilling to use it because of problems in defining the outcome in health and social services.

    Purchasers described dreadful stories about the risks related to innovation supportive procurement practices and therefore used more traditional and “safe” practices. Purchasers have been blamed for avoiding risks too extensively and active risk management has been highlighted (Kalvet & Lember, 2010; Elder et al., 2015). However, in the context of health and social services, there are excessive financial and ethical risks that can result from unwanted service outcomes. Perhaps general recommendations should not be provided either in PPI or in risk management, instead more studies presenting context-specific good practices could be needed.

  • 31827.
    Vähätalo, Mervi
    et al.
    University of Turku, Finland.
    Kallio, Tomi J.
    University of Turku, Finland.
    Tietojohtaminen hyvinvointialalla: nuorten terveyden ja hyvinvoinnin tukeminen internet-pohjaisilla menetelmillä2013Report (Other academic)
  • 31828.
    Vähätalo, Mervi
    et al.
    University of Turku, Finland.
    Kallio, Tomi J.
    Linnaeus University, School of Business and Economics, Department of Organisation and Entrepreneurship.
    Laiho, Maarit
    University of Turku, Finland.
    Suomi, Kati
    University of Turku, Finland.
    Tevameri, Terhi
    University of Turku, Finland.
    Institutional logics and efficiency pressures in public organizations: what about the healthcare sector?2018In: Paper presented at the 25th Annual EurOMA Conference, Budapest, Hungary, June 24-26, 2018, 2018, p. 1-8Conference paper (Refereed)
    Abstract [en]

    This study describes the current state of public sector logic from the perspective of healthcare professionals. More than 1500 healthcare professionals answered the survey concerning the way in which values, decision making and aims appear in the public sector. Healthcare professionals felt that the essential value in the public sector is still the respect for human life. However, they also argued that good care has become subordinate to financial values. In the current age of austerity, improving efficiency in the public sector is inevitable. However, it shouldn’t be done by jeopardizing professionals’ ability to work according to their professional logic.

  • 31829.
    Vänje, Annika
    et al.
    Kungliga tekniska högskolan (KTH).
    Antonsson, Ann-Beth
    Kungliga tekniska högskolan (KTH).
    Österman, Cecilia
    Kungliga tekniska högskolan (KTH).
    Nord Nilsson, Lena
    Kungliga tekniska högskolan (KTH).
    Nyman, Teresia
    Kungliga tekniska högskolan (KTH).
    Eklund, Jörgen
    Kungliga tekniska högskolan (KTH).
    Verksamhetsnära arbetsmiljöarbete: nyttiggörande av branschspecifika kunskaper om arbetsmiljöarbete Implementering av nätverk inom verkstadsindustrin och den kommunala hemtjänsten2016Report (Other academic)
    Abstract [sv]

    Detta är ett FoU projekt om branschspecifika arbetsmiljökunskaper inom verkstadsindustri och kommunala hemtjänst med företagshälsovård i fokus. Branscherna är varandras motsatser när det gäller aspekter som resurser för ledning och styrning av verksamheten, verksamhetsinriktning, traditioner kring systematiskt arbetsmiljöarbete och könsfördelning.

    Projektets övergripande syfte, var att utveckla tre metoder för att samla in, sprida och nyttiggöra branschspecifik kunskap om arbetsmiljöarbete. De tre metoderna är kompetensnätverk, webbportal för utveckling och spridning av branschspecifika kunskaper om arbetsmiljö samt vidareutbildning för yrkesverksamma inom arbetsmiljöområdet.

    Kunskapsutbyten har varit kärnan i kompetensnätverket för verkstadsindustrin, strategier för att möta motstånd och lösa så kallade problemprojekt identifierades. Viktiga aspekter var ett nära samarbete med kundorganisationen och medarbetare i verksamheten, tvärfunktionella projekt och att medverka från start i förändringsprojekt. I anslutning till dessa faktorer efterlystes tydliga stödstrukturer för ett integrerat och proaktivt arbetsmiljöarbete.

    Två orsaker till sjukskrivningar inom hemtjänsten som kompetensnätverkets medforskare lyfte fram var stora arbetsgrupper samt en hög personalomsättning. Vad som sågs som väsentligt för att motverka dessa två faktorer var ökad delaktighet vid resursfördelning och arbetsplanering. Det sågs även som centralt för utvecklingen av arbetsmiljön i denna bransch att identifiera och synliggöra motivatorer till att vara i arbete inom hemtjänsten. Vidare finns ett identifierat behov av en webbportal där information och kunskaper om arbetsmiljö är samlad. Innehållet i vidareutbildningen baseras på identifierade kunskapsbehov som att bedriva ett integrerat och proaktivt arbetsmiljöarbete.

    Den övergripande slutsatsen kring det branschspecifika är att det finns behov av kunskaper i att leda och driva arbetsmiljöarbete och förstå hur organisationen runt den lokala arbetsplatsen fungerar. Detta gäller för båda branscherna och skulle kunna beskrivas i termer av ett mesoperspektiv på arbetsmiljöarbetet, istället för ett microperspektiv.

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  • 31830.
    Wadbro, Eddie
    et al.
    Umeå university, Sweden.
    Engström, Christian
    Umeå university, Sweden.
    Topology and shape optimization of plasmonic nano-antennas2015In: Computer Methods in Applied Mechanics and Engineering, ISSN 0045-7825, E-ISSN 1879-2138, Vol. 293, p. 155-169Article in journal (Refereed)
    Abstract [en]

    Metallic nano-antennas are devices used to concentrate the energy in light into regions that are much smaller than the wavelength. These structures are currently used to develop new measurement and printing techniques, such as optical microscopy with sub-wavelength resolution, and high-resolution lithography. Here, we analyze and design a nano-antenna in a two-dimensional setting with the source being a planar TE-polarized wave. The design problem is to place silver and air in a pre-specified design region to maximize the electric energy in a small given target region. At optical frequencies silver exhibits extreme dielectric properties, having permittivity with a negative real part. We prove existence and uniqueness of solutions to the governing nonstandard Helmholtz equation with absorbing boundary conditions. To solve the design optimization problem, we develop a two-stage procedure. The first stage uses a material distribution parameterization and aims at finding a conceptual design without imposing any a priori information about the number of shapes of components comprising the nano-antenna. The second design stage uses a domain variation approach and aims at finding a precise shape. Both of the above design problems are formulated as non-linear mathematical programming problems that are solved using the method of moving asymptotes. The final designs perform very well and the electric energy in the target region is several orders of magnitude larger than when there is only air in the design region. The performance of the optimized designs is verified with a high order interior penalty method.

  • 31831.
    Wadenberg, Marie-Louise
    Karolinska Inst, Sect Neuropsychopharmacol, Stockholm, Sweden.
    A Review of the Properties of Spiradoline: A Potent and Selective Kappa-Opioid Receptor Agonist.2003In: CNS Drug Reviews, Vol. 9, no 2, p. 187-198Article, review/survey (Other academic)
  • 31832.
    Wadenberg, Marie-Louise
    Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences.
    Active Avoidance2010In: Encyclopedia of Psychopharmacology: Part 1 / [ed] Ian P Stolerman, Heidelberg: Springer, 2010, p. 15-19Chapter in book (Other academic)
  • 31833.
    Wadenberg, Marie-Louise
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Antagonism by 8-OH-DPAT, but not ritanserin, of catalepsy produced by raclopride or SCH 23 390 in the rat.1992In: J Neural Transm, Vol. 89, p. 49-59Article in journal (Refereed)
  • 31834.
    Wadenberg, Marie-Louise
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Bifeprunox: a novel antipsychotic agent with partial agonist properties at dopamine D2 and serotonin 5-HT1A receptors2007In: Future Neurology, ISSN 1479-6708, Vol. 2, no 2, p. 153-165Article in journal (Refereed)
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  • 31835.
    Wadenberg, Marie-Louise
    Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences.
    Conditioned avoidance response in the development of new antipsychotics.2010In: Current pharmaceutical design, ISSN 1381-6128, E-ISSN 1873-4286, Vol. 16, no 3, p. 358-370Article, review/survey (Refereed)
    Abstract [en]

    Schizophrenia presents with positive/psychotic, negative and cognitive symptoms. Positive symptoms seems due to a dopamine mesolimbic overreactivity, while negative/cognitive symptoms may conversely be due to mesocortical hypo-dopaminergia. Traditional dopamine D2 receptor blocking antipsychotics (e.g. haloperidol) are effective against psychotic/positive symptoms, but less so against negative/cognitive symptoms. Some D2 receptor blockage, however, seems necessary for efficacy against psychotic symptoms. Therefore, current antipsychotic drug improvement strategies include modest D2 receptor blockage, or partial D2 stimulation, combined with adjunct pharmacological properties that may enhance: i) D2 blockage efficacy; and ii) cognitive functioning. There are also strategies with no direct D2 blockage. Clinical activity is often tested in animal screening tests (so called animal models). The screening test conditioned avoidance response in rats has shown particular sensitivity, with high predictive validity, for detection of drug antipsychotic activity. The present review assessed the significance, accuracy and use of the conditioned avoidance response test as a screening tool in current antipsychotic drug development. It was found that: i) the conditioned avoidance response test holds a strong position, is frequently used in current antipsychotic drug development, and is commonly considered a reliable screening tool, with high predictive validity, for the detection of potential antipsychotic activity; ii) in current antipsychotic drug development, the conditioned avoidance response test is able to detect pharmacological properties contributing to antipsychotic activity in the presence of sub-therapeutic D2 receptor blockade, as well as detecting antipsychotic activity of compounds having no direct D2 blocking properties.

  • 31836.
    Wadenberg, Marie-Louise
    Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences.
    Current Pro-Cognitive Therapeutic Strategies for Improved Pharmacological Treatment in Schizophrenia2014In: Current pharmaceutical design, ISSN 1381-6128, E-ISSN 1873-4286, Vol. 20, no 31, p. 5045-5045Article in journal (Other academic)
    Abstract [en]

    Cognitive impairment influencing memory, attentional focus and executive functions in schizophrenia have a significant impact on social functioning and quality of life. Cognitive functions depend on normal functioning of brain prefrontal cortex. Attempts to explain cognitive impairment in schizophrenia include hypotheses (based on among others post-mortem, genetic and imaging data) of dysfunctions involving dopamine, glutamate, GABA as well as acetylcholine neural transmission. Current antipsychotic drugs are not sufficiently effective against cognitive symptoms. Thus, while pharmacological treatment strategies earlier primarily focused on managing psychotic (so called positive) symptoms, current pharmacological strategies aim at identifying compounds with pro-cognitive properties, suitable for treatment of cognitive symptoms as manifested in schizophrenia. To this end, scientists are primarily working along two lines: i) developing animal models/tests in rodents with relevance either to cognitive symptoms as presented in schizophrenia and/or to brain abnormalities in schizophrenia believed to be causing these symptoms; ii) identifying pro-cognitive compounds with pharmacological properties acting on brain neurotransmitter functions believed to be involved in cognitive dysfunction in schizophrenia. The present special issue on ‘Current pro-cognitive therapeutic strategies for improved pharmacological treatment in schizophrenia’ includes presentation and discussion of the use of the attentional set-shifting test as a relevant model for attentional/executive functioning in schizophrenia as well as for the identification of pro-cognitive compounds with relevance to schizophrenia treatment Tait et al. [1] and Goetghebeur and Dias [2], presentation of the neurodevelopmental prenatal methylazoxymethanol acetate (MAM) model of schizophrenia by Gill and Grace [3], and discussion of the novel object recognition (NOR) task for memory functions by Rajagopal et al. [6]. In addition, putative procognitive treatment strategies for schizophrenia treatment such as the use of GABAA receptor agonists [3], the use of compounds acting at nicotinic acetylcholine receptors from a clinical perspective Boggs et al. [4], as well as the therapeutic significance of compounds (phosphodiesterase, PDE, inhibitors) influencing intracellular signaling Snyder and Vanover [5] are presented and discussed. Finally, data on the effects of atypical antipsychotics, as well as 5-HT1A partial agonists, 5-HT7 antagonists, and D1 agonists in the NOR test are reviewed by Rajagopal et al. [6]. The contributors are all distinguished scientists, and issues discussed in the articles are timely and of great importance for the advancement of effective schizophrenia treatment strategies. Therefore, this special issue will hopefully be well received and appreciated in the scientific community dealing with these issues.

  • 31837.
    Wadenberg, Marie-Louise
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Drug Evaluation: Iloperidone1998In: Curr Res in Serotonin, Vol. 3, p. 66-69Article, review/survey (Other academic)
  • 31838.
    Wadenberg, Marie-Louise
    UNIV STOCKHOLM, DEPT PSYCHOL, S-10691 STOCKHOLM, SWEDEN.
    Serotonergic mechanisms in neuroleptic-induced catalepsy in the rat.1996In: Neurosci and Biobehav Reviews, Vol. 20, p. 325-339Article, review/survey (Other academic)
    Abstract [en]

    The present paper reviews a series of experiments aimed at elucidating the interaction between specific dopamine (DA) and 5-hydroxytryptamine (5-HT) receptors in the mediation of extrapyramidal motor functions in the rat. There is strong evidence to suggest that (1) the catalepsy produced by dopamine D-1 or D-2 receptor antagonists can be completely antagonized by the administration of 5-HT1A receptor agonists acting at 5-HT autoreceptors in the median raphe nucleus; (2) the catalepsy produced by a dopamine D-2 receptor antagonist can be completely antagonized by treatment with a 5-HT2A/C receptor agonist; and (3) the catalepsy produced by blockade of either dopamine D-1 or D-2 receptors is not affected by the administration of a 5-HT2A/C receptor antagonist. The emerging picture of DA/5-HT receptor interactions in the mediation of extrapyramidal motor functions is of great interest in relation to present efforts to develop new atypical neuroleptics with affinity for brain 5-HT receptor subtypes, and also for the observations that new serotonin selective re-uptake inhibiting antidepressants can produce parkinson-like symptoms in vulnerable individuals.

  • 31839.
    Wadenberg, Marie-Louise
    et al.
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Ahlenius, Sven
    Antagonism by the 5-HT2A/C receptor agonist DOI of raclopride-induced catalepsy in the rat.1995In: Eur J Pharmacol, Vol. 294, p. 247-251Article in journal (Refereed)
  • 31840.
    Wadenberg, Marie-Louise
    et al.
    Department of Psychology, University of Stockholm .
    Ahlenius, Sven
    Antipsychotic-like profile of combined treatment with raclopride and 8-OH-DPAT in the rat: Enhancement of antipsychotic-like effects without catalepsy.1991In: Journal of neural transmission, ISSN 0300-9564, E-ISSN 1435-1463, Vol. 83, p. 43-53Article in journal (Refereed)
    Abstract [en]

    The administration of the 5-HT1A agonist 8-OH-DPAT,0.1 mg kg- 1 sc - - 20 min, produced a moderate suppression of conditionedavoidance behavior (60% of controls) in the rat. This effect, however, was notseen after administration of higher doses, 0.4 and 1.6 mg kg- 1 sc. The numberof intertrial crosses were not affected by the lower dose but significantly increasedby administration of the two higher doses of 8-OH-DPAT. The dopamineD 2 receptor blocking agent raclopride, 0.05 mgkg-t, by itself did notsuppress the avoidance behavior, but in combination with 8-OH-DPAT producedsuppression of avoidance behavior (30% of controls) as well as intertrialcrosses. Open field locomotor activity was suppressed by raclopride,0.1 mg kg- 1 sc, or by 8-OH-DPAT, 0.1 mg kg- 1 sc. The combined treatmentproduced a further suppression of locomotor activity and a marked increasein "immobility" (stationary movements). Treadmill locomotion, however, wasnot affected by either compound by itself, whereas the combined treatmentimpaired treadmill performance. Suppression of treadmill performance by ahigher dose of raclopride, 0.4mgkg-~sc, was not altered by the additionaltreatment with 8-OH-DPAT, 0.1 mg kg- 1. In contrast to the additive effects of8-OH-DPAT and raclopride on conditioned avoidance behavior, open fieldlocomotion and treadmill performance, the catalepsy produced by raclopride,16mgkg -1 was completely antagonised by treatment with 8-OH-DPAT0.1 mg kg-1. Taken together, the present findings demonstrate strong interactionsbetween a 5-HT agonist and a DAD 2 antagonist on some critical testsfor antipsychotic-like actions and extrapyramidal motor effects in rats, andsuggest new possibilities in the search for new antipsychotic drugs with higherclinical efficacy and less extrapyramidal side effects. 

  • 31841.
    Wadenberg, Marie-Louise
    et al.
    Department of Psychology, University of Stockholm .
    Ahlenius, Sven
    Effects of raclopride and haloperidol on spontaneous motor activity and on conditioned avoidance behavior in rats: A comparison of potency, efficacy and time-course of action.1991In: Arzneimittel-Forschung / Drug Res, ISSN 0004-4172, Vol. 41, no 7, p. 692-695Article in journal (Refereed)
    Abstract [en]

    The spontaneous locomotor activity of rats was used as an index of centrally mediated of raclopride (CAS 84225-95-6). The results indicate a duration of less than 2 h after s.c administration of 2 μmol kg-1. In support of a rapid first-pass metabolism in the rat, the effect was considerably weaker after i.p. administration. This difference was further supported by comparing the dose-effect curves after s.c. and i.p. raclopride administration. Halopéridol appears to be slightly more potent than raclopride 

  • 31842.
    Wadenberg, Marie-Louise
    et al.
    Department of Psychology, University of Stockholm.
    Ahlenius, Sven
    Suppression of conditioned avoidance by 8-OH-DPAT in the rat.1988In: Journal of neural transmission, ISSN 0300-9564, E-ISSN 1435-1463, Vol. 74, no 3, p. 195-198Article in journal (Refereed)
    Abstract [en]

    Rats were trained to perform an aversely motivated discriminative task in a shuttle-box. The conditioned avoidance response was selectively suppressed by 8-OH-DPAT in a dose-dependent manner (25–100 g·kg–1). There were no statistically significant deficits in discriminative performance. The present results suggest antipsychotic-like properties of 8-OH-DPAT. 

  • 31843.
    Wadenberg, Marie-Louise
    et al.
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Ahlenius, Sven
    Svensson, Torgny
    Potency mismatch for behavioral and biochemical effects by dopamine receptor antagonists: implications for the mechanism of action of clozapine.1993In: Psychopharmacology, Vol. 110, p. 273-279Article in journal (Refereed)
  • 31844.
    Wadenberg, Marie-Louise
    et al.
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Cortizo, Lourdes
    Evidence for specific 5-HT1A and dopamine D2 receptor interactions in the mediation of extrapyramidal motor functions in the rat.1994In: Pharmacol Biochem Behav, Vol. 47, p. 509-513Article in journal (Refereed)
  • 31845.
    Wadenberg, Marie-Louise
    et al.
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Elia, Yesmino
    The selective dopamine D-4 receptor antagonist L-745,870 produces antipsychotic-like effects in the presence of a weak dopamine D2 receptor blockade in rats.2001In: Nord J Psychiat, Vol. 55Article in journal (Refereed)
  • 31846.
    Wadenberg, Marie-Louise
    et al.
    Department of Psychology, University of Stockholm .
    Ericsson, Eva-Lena
    Magnusson, Olle
    Ahlenius, Sven
    Suppression of conditioned avoidance behavior by the local application of (-)sulpiride into the ventral, but not the dorsal, striatum of the rat.1990In: Biological Psychiatry, ISSN 0006-3223, E-ISSN 1873-2402, Vol. 28, no 4, p. 297-307Article in journal (Refereed)
    Abstract [en]

    The local application of (−)sulpiride, 200 ng side−1, into the nucleus accumbens produced a suppression of conditioned avoidance behavior in male rats, 10 and 90 min after injection. The decrease in avoidance behavior was accompained by a decrease in motor activity, as evidenced by changes in the number of intertrial crosses. When injected into the dorsolateral neostriatum, or the amygdala, (−)sulpiride produced a suppression of conditioned avoidance behavior at the 90-min time interval only. Considering diffusion from the injection site, as indicated by an increase in local dopamine turnover [(DO-PAC+HVA) DA−1], the effects obtained in the dorsolateral neostriatum, and possibly also the amygdala, 90 min after injection could be due to diffusion to the nucleus accumbens. The local application of (-) sulpiride into the posterior neostriatum, or into the prefrontal cortex, produced no statistically significant effect on conditioned avoidance behavior 10 or 90 min after injection. It is concluded that the performance of conditioned avoidance behavior in the rat is critically dependent on an intact dopaminergic neurotransmission in the nucleus accumbens or adjacent areas of the ventral striatum. 

  • 31847.
    Wadenberg, Marie-Louise
    et al.
    Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences.
    Fjällström, Ann-Kristin
    Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences.
    Federley, Malin
    Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences.
    Persson, Pernilla
    Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences.
    Stenqvist, Pia
    Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences.
    Effects of adjunct galantamine to risperidone, or haloperidol, in animal models of antipsychotic activity and extrapyramidal side-effect liability: involvement of the cholinergic muscarinic receptor2011In: International Journal of Neuropsychopharmacology, ISSN 1461-1457, E-ISSN 1469-5111, Vol. 14, no 5, p. 644-654Article in journal (Refereed)
    Abstract [en]

    The acetylcholine esterase inhibitor/cholinergic nicotinic receptor (nAChR) allosteric modulator galantamine (Gal) is used against cognitive impairment in Alzheimer’s disease. Negative/cognitive and psychotic symptom improvement in schizophrenia by adjunct Gal to antipsychotic drugs (APDs) has been reported. Cognitive symptoms in schizophrenia may involve brain prefrontal hypo-dopaminergia. Experimental data by others indicate nAChR involvement in animal pro-cognitive effects of Gal. The role of nAChRs in antipsychotic effects by Gal has, however, not been elucidated. Using the conditioned avoidance response (CAR) and the catalepsy tests for antipsychotic activity and extrapyramidal side-effect (EPS) liability, respectively, we here investigated the effects of adjunct Gal (1.25 mg/kg) to the typical APD haloperidol (Hal) (0.05 mg/kg), or the atypical APD risperidone (Ris) (0.2 mg/kg), in rats. Adjunct Gal significantly enhanced APD-like effects by low doses of Hal or Ris, but showed a safe EPS liability profile only in combination with Ris. Pretreatment with the muscarinic receptor (mAChR) antagonist scopolamine, but not the nAChR antagonist mecamylamine, completely reversed the enhancing effects of adjunct Gal to Hal treatment, in the CAR test. While the nAChR-modulating properties of Gal probably contribute to pro-cognitive activity, as shown by others, the present data suggest that any contribution to antipsychotic activity by Gal is mediated primarily via mAChRs. This property combination of Gal may offer a unique, favourable therapeutic profile for schizophrenia treatment.

  • 31848.
    Wadenberg, Marie-Louise
    et al.
    Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences.
    Fjällström, Ann-Kristin
    Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences.
    Karlsson-Federley, Malin
    Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences.
    Persson, Pernilla
    Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences.
    Stenqvist, Pia
    Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences.
    Effects of adjunct galantamine to antipsychotics in animal models of antipsychotic activity and extrapyramidal side effect liability: Cholinergic muscarinic receptor mediation2010In: International Journal of Neuropsychopharmacology, ISSN 1461-1457, E-ISSN 1469-5111, Vol. 13, no Suppl. 1, p. 111-Article in journal (Other academic)
  • 31849.
    Wadenberg, Marie-Louise
    et al.
    University of Kalmar, School of Pure and Applied Natural Sciences.
    Hertel, P
    Fernholm, Rita
    Svensson, TH
    Hygge-Blakeman, Karin
    Ahlenius, Sven
    Enhancement of antipsychotic-like effects by combined treatment with the α1-adrenoceptor antagonist prazosin and the dopamine D2 receptor antagonist raclopride in rats2000In: J Neural Transm, Vol. 107, p. 1229-1238Article in journal (Refereed)
  • 31850.
    Wadenberg, Marie-Louise
    et al.
    Department of Psychiatry, Scott & White Clinic, Temple, TX 75608, USA..
    Hicks, Paul
    The conditioned avoidance response test re-evaluated: Is it a sensitive test also for the detection of potentially atypical antipsychotics?1999In: Neurosci and Biobehav Reviews, Vol. 23, no 6, p. 851-862Article, review/survey (Other academic)
    Abstract [en]

    The present review discusses the history and paradigm of the conditioned avoidance response (CAR) in rats for the detection of potential antipsychotic activity of drugs. In addition, the role of dopamine (DA) D2, serotonin (5-HT)2A/2C, alpha1, 5-HT1A, DA D4, muscarinic and glutamate receptors in the suppression of CAR induced by various classes of drugs is evaluated. Finally, data investigating brain sites of action for the mediation of CAR behavior is discussed. It is concluded that the CAR test, originally found to be sensitive for the detection of antipsychotic drugs with high affinity as antagonists for brain dopamine receptors, is also sensitive for the detection of potentially antipsychotic compounds acting primarily via neurotransmitter receptors other than the DA D2 receptor. Furthermore, the review confirms the importance of the nucleus accumbens(shell) in the mediation of effects on CAR produced by traditional, as well as atypical antipsychotic drugs.

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