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  • 1.
    Andersson, Håkan S.
    et al.
    Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences.
    Jacobsson, Erik
    Uppsala University.
    Eriksson, Camilla
    Uppsala University.
    Hedström, Martin
    Lund University.
    Seth, Henrik
    Gothenburg University.
    McEvoy, Eric G
    Sundberg, Per
    Gothenburg University.
    Strand, Malin
    Swedish agricultural university (SLU).
    Discovery of peptide toxins in the world’s longest animal (The bootlace worm; Lineus longissimus): challenging claims of tetrodotoxin production.2015Conference paper (Other academic)
  • 2.
    Daly, Norelle
    et al.
    Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072 Australia.
    Rosengren, K. Johan
    Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072 Australia.
    Craik, David
    Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072 Australia.
    Discovery, structure and biological activities of cyclotides2009In: Advanced Drug Delivery Reviews, ISSN 0169-409X, E-ISSN 1872-8294, Vol. 61, p. 918-930Article, review/survey (Other academic)
    Abstract [en]

    Cyclotides are small disulfide-rich peptides that are characterized by a head-to-tail cyclized peptide backbone and a knotted arrangement of three conserved disulfide bonds. They are present in many plants from the Violaceae, Rubiaceae and Cucurbitaceae families, with individual plants expressing a suite of dozens of cyclotides. So far > 140 sequences and 15 three-dimensional structures have been determined but it is estimated that the family probably comprises many thousands of members. Their primary function in plants is thought to be as defense agents, based on their potent insecticidal activity, but they also have a range of other biological activities, including anti-HIV, antimicrobial and cytotoxic activities. Because of their exceptional stability they have attracted interest as templates for protein engineering and drug design applications. This article gives an overview of the discovery of cyclotides, describes their unique structural features and range of bioactivities, and discusses their applications in drug design.

  • 3.
    Jacobsson, Erik
    et al.
    Uppsala University.
    Andersson, Håkan S.
    Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences.
    Strand, Malin
    Swedish agricultural university (SLU).
    Eriksson, Camilla
    Uppsala University.
    Göransson, Ulf
    Uppsala University.
    Peptide toxins from L. longissimus: extraction, biological activity, structure and production2015Conference paper (Other academic)
1 - 3 of 3
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