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  • 1. Lundgren, Brita A
    et al.
    Rorsman, Fredrik
    Portela-Gomes, G
    Grimelius, Lars
    Nilsson Ekdahl, Kristina
    Linnaeus University, Faculty of Science and Engineering, School of Natural Sciences.
    Nilsson, Bo
    Ekwall, Olof
    Identification of complement C3 as an autoantigen in inflammatory bowel disease2010In: Journal of Gastroenterology and Hepatology, ISSN 0815-9319, E-ISSN 1440-1746, Vol. 2, no 4, p. 429-436Article in journal (Refereed)
  • 2.
    Thorgersen, Ebbe Billmann
    et al.
    Oslo Univ Hosp, Norway;Univ Oslo, Norway.
    Barratt-Due, Andreas
    Oslo Univ Hosp, Norway;Univ Oslo, Norway.
    Haugaa, Hakon
    Oslo Univ Hosp, Norway;Lovisenberg Diaconal Univ Coll, Norway.
    Harboe, Morten
    Oslo Univ Hosp, Norway;Univ Oslo, Norway.
    Pischke, Soren Erik
    Oslo Univ Hosp, Norway;Univ Oslo, Norway.
    Nilsson, Per H.
    Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences. Oslo Univ Hosp, Norway;Univ Oslo, Norway.
    Mollnes, Tom Eirik
    Oslo Univ Hosp, Norway;Univ Oslo, Norway;Nordland Hosp, Norway;Univ Tromsö, Norway;Norwegian Univ Sci & Technol, Norway.
    The Role of Complement in Liver Injury, Regeneration, and Transplantation2019In: Hepatology, ISSN 0270-9139, E-ISSN 1527-3350, Vol. 70, no 2, p. 725-736Article in journal (Refereed)
    Abstract [en]

    The liver is both an immunologically complex and a privileged organ. The innate immune system is a central player, in which the complement system emerges as a pivotal part of liver homeostasis, immune responses, and crosstalk with other effector systems in both innate and adaptive immunity. The liver produces the majority of the complement proteins and is the home of important immune cells such as Kupffer cells. Liver immune responses are delicately tuned between tolerance to many antigens flowing in from the alimentary tract, a tolerance that likely makes the liver less prone to rejection than other solid organ transplants, and reaction to local injury, systemic inflammation, and regeneration. Notably, complement is a double-edged sword as activation is detrimental by inducing inflammatory tissue damage in, for example, ischemia-reperfusion injury and transplant rejection yet is beneficial for liver tissue regeneration. Therapeutic complement inhibition is rapidly developing for routine clinical treatment of several diseases. In the liver, targeted inhibition of damaged tissue may be a rational and promising approach to avoid further tissue destruction and simultaneously preserve beneficial effects of complement in areas of proliferation. Here, we argue that complement is a key system to manipulate in the liver in several clinical settings, including liver injury and regeneration after major surgery and preservation of the organ during transplantation.

  • 3.
    Wall, R.
    et al.
    Örebro University.
    Marques, T.
    Örebro University.
    Edebol-Carlman, H.
    Örebro University.
    Sundin, J.
    University of Gothenburg.
    Vumma, Ravi
    Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences.
    Rangel, I.
    Örebro University.
    Brummer, R.
    Örebro University.
    Altered expression of membrane transporters in colonic mucosa of patients with Irritable Bowel Syndrome (IBS) and Post-infectious (PI)-IBS compared to healthy subjects2017In: Neurogastroenterology and Motility, ISSN 1350-1925, E-ISSN 1365-2982, Vol. 29, no Supplement 2, p. 107-108, article id 219Article in journal (Other academic)
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