Isolation, structure elucidation and synthesis of cytotoxic compound(s) from bee venom as anticancer lead in hepatocellular carcinoma model

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Title [sv]

Isolering, strukturutredning och syntes av cytotoxiska substanser ur bigift för att identifiera anti-cancerkandidater i en modell för hepatocellulärt carcinom

Title [en]

Isolation, structure elucidation and synthesis of cytotoxic compound(s) from bee venom as anticancer lead in hepatocellular carcinoma model

Abstract [en]

For over 40 years, natural products have served us well in combating cancer. The main sources of these successful compounds are microbes and plants from the nature. A major contribution comes from plant alkaloids, taxoids and podophyllotoxins. A vast array of biological metabolites can be obtained from the bee-honey natural products, which can be used for effective cancer treatment. The search for novel drugs is still a priority goal for cancer therapy, due to the rapid development of resistance to chemotherapeutic drugs. In addition, the high toxicity usually associated with some cancer chemotherapy drugs. Hepatocellular carcinoma is one of the leading causes of death in Egypt and globally the numbers of cases of this cancer are increasing gradually. There are several medicines available in the market to treat this type of cancer and they are found to be not fully effective and/or safe. However natural products have proved effective and safe in the treatment and management of some other types of cancer. Here an attempt will be made topave the way of using natural products isolated from bee venom and their small and large molecules analogues to combat hepatocellular carcinoma.