This research has demonstrated for the first time the possibility of manufacturing models of Medium Density Fiber board (MDF)   from Cotton Seeds hulls as a Waste by-Product of Cotton with good physical Specifications comply with European specifications EN (DIN1999).  Decrease in the average ability of models wood panels manufactured Medium Density Fiber board (MDF) of Seeds hulls to water absorption and the Cross-Swilling after 24h with the increasing Proportion of each the glue used, harder and formaldehyde scavenger used.  All models wood panels manufactured Medium Density Fiber board (MDF) Seeds hulls, which glued with 14% characterized  with bad physical specification dont Comply with European standards for technical quality EN (DIN1999) and must be excluded.  All models wood panels manufactured Medium Density Fiber board (MDF) of Seeds hulls, which glued with 16% and 18% characterized with good physical Specifications Comply with European standards specifications, while the models glued with 18% characterized with soperior physical specifications for high technical quality, making it very good for the manufacture of furniture and coating halls.