In this chapter, we ask What means Latin American family? First, we frame Latin American families from the socio-historical perspective, considering the works of Robichaux, about indigenous family patterns in Mesoamerica, and Therborn, who analysed creole families in the global context of the twentieth century. In the second section, a sociodemographic emphasis compares and contrasts family trends among Latin American countries with regard to other countries and regions of the world. The third and fourth sections develop issues concerning gender inequalities, gender diversity, sexual rights, migration, and the Pandemic. Sociological and political points of view fuse in the third, fourth, and fifth sections, which are among the most significant issues in the contemporary debate and their relation to families in Latin America. Selected cases of nation-states allow us to discuss the potential links between global issues and family life. At this point in the chapter, internal stratification remains evident, as is the phenomenon of inter-country inequalities in the region. Considering the “entanglement” between gender, race, age, and the resources needed for the daily life of Latin American families, similitudes, differences, and inequalities beyond the mere definition of family organisation arise. Moreover, the paper shows a persistent bimodal behaviour as a general pattern in one of the world’s most unequal regions.