In this introduction to “Truth Claims Across Media,” we approach pressing questions related to facts and fakes, authority and authenticity, information and disinformation through an intermedial perspective. As digital technology allows us to blend different media and modes on an unprecedented scale, we need to delve deeper into how our media choices impact our perception of truthfulness. We present the concepts of truthfulness and truth claims, examining what kind of knowledge about the actual world can be derived from specific media products. The intermedial perspective serves as a lens through which we can elucidate how the interplay between facts, coherence, and audience engagement varies in different media contexts. From this perspective, it becomes possible to discuss how media choices influence knowledge production and relate to the evolving demands for authenticity and witnessing in today’s shifting media landscape.