This research has demonstrated the possibility of manufacturing models of Medium Density Fiber board (MDF)   from Cotton Seeds hulls as a Waste by-Product of Cotton with good Chemical Specifications comply with European specifications EN (DIN1999). Decrease in the average ability of models wood panels manufactured Medium Density Fiber board (MDF) of Cotton Seeds hulls to Formaldehyde release with the increasing Proportion of formaldehyde scavenger used, therefore the models containing 2% formaldehyde scavenger enjoy high-health quality. All models wood panels manufactured Medium Density Fiber board (MDF) of Cotton Seeds hulls characterized with good chemical specification (Formaldehyde release) Comply with European specifications EN (DIN1999) and enjoid a good health quality.