We deduce continuity properties for pseudo-differential operators with symbols in Orlicz modulation spaces when acting on other Orlicz modulation spaces. In particular we extend well-known results in the literature. For example we generalize the classical result by Cordero and Nicola that if [Formula presented], pj,qj⩽q′,q⩽p and a∈Mp,q, then the pseudo-differential operator Op(a) is continuous from Mp to Mp. We also show that the entropy functional Eϕ possess suitable continuity properties on a suitable Orlicz modulation space MΦ satisfying Mp⊆MΦ⊆M2, though Eϕ is discontinuous on M2=L2.