The aim of this essay is to investigate the relation between adaptation and intermediality and to demonstrate why adaptation studies would profit from a broad intermedial research context. A list of ten ways of delimiting the notion of adaptation within the broader field of intermediality is presented and thoroughly discussed. The goal is to pinpoint border zones of adaptation that are only partly recognized as such by adaptation scholars. It is argued that failing to reflect on these borders ignores relevant neighbor disciplines, and that insufficient attention to related theoretical fields reduces the possibility for adaptation studies to produce research that is relevant for a broader range of phenomena and a broader field of scholars. The essay also briefly investigates some core issues of intermedial research, and hence of adaptation studies, and summarizes some vital notions that are helpful for investigating essential similarities and differences among media and for capturing the material and semiotic conditions for adaptation.