Handheld computing and mobile information systems are continuously breaking new ground, with an increased importance for business. However, there is evidence that we still have lessons to learn concerning the design of handheld information systems. Handheld information system poses challenges to the designer in the unique properties of handheld technologies and the conditions of use of handheld technologies. Hence, this paper is based on the assumption that handheld information systems has unique properties, and dependencies between properties, that should to be considered in the design of such a system in order to design appropriate information systems for the mobile workforce. The purpose in this paper is to further enhance the usefulness of the Accentuated Factor Framework by describing dependencies between factors in the framework and by this enhance the efficacy in the design process. The theoretical foundation for the paper is the Accentuated Factor Framework, illustrating the unique properties of handheld information systems whereas the expected use settings are the mobile workforce. The empirical data collection was performed via interviews with experienced practitioners, case studies, workshops and studies of software. The Accentuated Factor Framework enhanced with explanatory dependencies between factors provides the opportunity to enhance the design process by reducing the risk of reengineering in design.