Changes of blood viscosity in pateints treated with 5-fluorouracil: A link to cardiotoxicity?Show others and affiliations
1995 (English)In: Acta Oncologica, ISSN 0284-186X, E-ISSN 1651-226X, Vol. 34, no 1, p. 83-85Article in journal (Refereed) Published
Abstract [en]
Abstract
Cardiotoxicity is a serious but relatively unknown side-effect of treatment with 5-fluorouracil (5-FU). The underlying mechanism of 5-FU cardiotoxicity has not been defined. The aim of the present study was to determine whether hemorheological factors might in part explain 5-FU cardiotoxicity. Changes of blood and plasma viscosity, fibrinogen and hematocrit were studied in 11 patients treated by 5-FU.
The study showed a decrease in blood and plasma viscosity during treatment with 5-FU, probably caused by a decrease of plasma fibrinogen. Reversible cardiotoxic effects were demonstrated in four patients.
Place, publisher, year, edition, pages
Norway, 1995. Vol. 34, no 1, p. 83-85
Keywords [en]
Cardiotoxicity; Blood viscosity; Fluorouracil; Head and neck neoplasms; Drug therapy;
National Category
Medical and Health Sciences
Research subject
Natural Science, Biomedical Sciences; Health and Caring Sciences, Caring Science
Identifiers
URN: urn:nbn:se:lnu:diva-11712OAI: oai:DiVA.org:lnu-11712DiVA, id: diva2:417292
2011-05-162011-05-162017-12-11Bibliographically approved