According to the Institute of Medicine (IOM) report “To Err is Human” the injuries from medical errors are immense and the majority of the errors do not result from individual recklessness but from the flaws in the way the healthcare is delivered. This study is about a five qualities (5Qs) model which is a system including Human Factors Approach to quality and Patient Safety. The purpose of this paper is to demonstrate the integrated 5Qs and ergonomic as a new approach to build an effective and safe patient care environment and provide the guard of reducing medical and non-medical errors and increasing patient safety.