If, as recent scholarly insights suggest, adherence to Jesus was a largely intra-Jewish affair during the first few centuries CE, it increases the likelihood of interaction and exchange of ideas between such Jesus-oriented Jews and Jews of other inclinations. This article argues that the motif of the atoning power of the death of the beloved son – developed within first-century Judaism, as evidenced by Paul and the Gospels, and embraced by Jesus-oriented groups – was later reappropriated by Rabbinic Judaism through interaction with Jesus-oriented groups with a Jewish self-identity, and applied by Rabbinic Jews to Isaac. The presence of the aqedah motif in synagogues from the third to six centuries may testify to the reappropriation by non-Jesus-oriented Jews of the motif of the atoning power of the death of the beloved son, and possibly also to the presence and impact of Jesus-oriented groups or individuals in the synagogue of late antiquity.